ES2137694T3 - Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas. - Google Patents

Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas.

Info

Publication number
ES2137694T3
ES2137694T3 ES96916030T ES96916030T ES2137694T3 ES 2137694 T3 ES2137694 T3 ES 2137694T3 ES 96916030 T ES96916030 T ES 96916030T ES 96916030 T ES96916030 T ES 96916030T ES 2137694 T3 ES2137694 T3 ES 2137694T3
Authority
ES
Spain
Prior art keywords
hyaluronic acid
acid
esters
heavy metal
metal salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96916030T
Other languages
English (en)
Inventor
Riaz Khan
A Paul Konowicz
Antonella Flaibani
Valentina Gombac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anika Therapeutics SRL
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Application granted granted Critical
Publication of ES2137694T3 publication Critical patent/ES2137694T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN DERIVADOS DEL ACIDO HIALURONICO O DE ESTERES DEL ACIDO HIALURONICO, EN LOS CUALES UNA O MAS FUNCIONES HIDROXILO DE SUS UNIDADES REPETIDAS ALTERNANTES DE ACIDO 1,4 TAN ESTERIFICADAS CON UN GRUPO CARBOXILO DEL ACIDO SUCCINICO, PARA FORMAR EL HEMIESTER SUCCINICO DEL ACIDO HIALURONICO O DE ESTERES DEL ACIDO HIALURONICO. ESTOS DERIVADOS SE UTILIZAN PARA PREPARAR LAS CORRESPONDIENTES SALES DE METAL PESADO DE HEMIESTERES SUCCINICOS DEL ACIDO HIALURONICO O CON ESTERES TOTALES O PARCIALES DEL ACIDO HIALURONICO. ESTAS SALES SE UTILIZAN COMO PRINCIPIOS ACTIVOS EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS PARA SER UTILIZADAS COMO AGENTES ANTIBACTERIANOS Y DESINFECTANTES PARA EL TRATAMIENTO DE HERIDAS, QUEMADURAS Y OFTALMIAS, O COMO AGENTES ANTI PREPARACION DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES OSTEOARTICULARES.
ES96916030T 1995-05-10 1996-05-08 Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas. Expired - Lifetime ES2137694T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95PD000090A IT1281877B1 (it) 1995-05-10 1995-05-10 Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici

Publications (1)

Publication Number Publication Date
ES2137694T3 true ES2137694T3 (es) 1999-12-16

Family

ID=11391041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96916030T Expired - Lifetime ES2137694T3 (es) 1995-05-10 1996-05-08 Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas.

Country Status (9)

Country Link
EP (1) EP0827514B1 (es)
JP (1) JP4264671B2 (es)
AT (1) ATE183206T1 (es)
AU (1) AU695512B2 (es)
CA (1) CA2220682C (es)
DE (1) DE69603721T2 (es)
ES (1) ES2137694T3 (es)
IT (1) IT1281877B1 (es)
WO (1) WO1996035720A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69632996T2 (de) * 1995-12-26 2005-07-21 Toyo Boseki K.K. In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US6872819B1 (en) * 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
JP2003089647A (ja) * 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
NZ515999A (en) * 1999-06-18 2004-03-26 Ml Lab Plc Biologically active materials
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
WO2004024197A1 (en) 2002-09-11 2004-03-25 Johnson & Johnson Medical Limited Wound dressing materials comprising complexes of anionic polysaccharides with silver
DK200301128A (da) 2003-08-05 2005-02-06 Thomsen Joern Oddershede Tilskudspræparat
US7993678B2 (en) * 2005-09-26 2011-08-09 Novozymes Biopolymer A/S Hyaluronic acid derivatives
IT1402786B1 (it) 2010-11-19 2013-09-18 Fidia Farmaceutici Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
PT3226905T (pt) 2014-02-27 2022-01-19 Synartro Ab Conjugados de hialuronano com substâncias farmaceuticamente ativas, métodos e composições
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
MA41912A (fr) * 2015-04-07 2018-02-13 Hyalblue S R L Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
WO2019121488A1 (en) * 2017-12-21 2019-06-27 Nicox S.A. Nitric oxide releasing hyaluronic esters
JP7066909B1 (ja) * 2020-12-25 2022-05-13 参天製薬株式会社 高分子化合物、銀塩およびイオン性等張化剤を含有する水性点眼液
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
IT202200004613A1 (it) 2022-03-10 2023-09-10 Cmed Aesthetics S R L “procedimento di preparazione di prodotti sterili”
WO2024038087A1 (en) 2022-08-16 2024-02-22 Synartro Ab Method for preparing sterile compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5436388A (en) * 1977-08-26 1979-03-17 Sumitomo Electric Ind Ltd Porous polysaccharide and its preparation
EP0066283B1 (en) * 1981-06-02 1986-09-10 Eupan Corporation Eustatic composition for nonspecifically facilitating and amplifying the generalized homeostatic regulation and maintenance, compensation and repair in living organisms
CA1291034C (en) * 1987-10-19 1991-10-22 Mostafa S. Fahim Composition for promoting epithelial regeneration
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents

Also Published As

Publication number Publication date
CA2220682A1 (en) 1996-11-14
CA2220682C (en) 2006-10-24
EP0827514B1 (en) 1999-08-11
JPH11504668A (ja) 1999-04-27
AU695512B2 (en) 1998-08-13
ITPD950090A1 (it) 1996-11-10
DE69603721D1 (de) 1999-09-16
JP4264671B2 (ja) 2009-05-20
IT1281877B1 (it) 1998-03-03
ITPD950090A0 (it) 1995-05-10
DE69603721T2 (de) 2000-01-13
ATE183206T1 (de) 1999-08-15
AU5894496A (en) 1996-11-29
WO1996035720A1 (en) 1996-11-14
EP0827514A1 (en) 1998-03-11

Similar Documents

Publication Publication Date Title
ES2137694T3 (es) Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas.
ES2145118T3 (es) Derivados de acidos grasos y composiciones farmaceuticas que los contienen.
ECSP941104A (es) Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ES2080837T3 (es) Tratamiento de estados y enfermedades.
ES2126572T3 (es) Biblioteca de bio-oligomeros aleatorios, su metodo de sintesis y su metodo de uso.
AR003220A1 (es) Derivados acilados de melatonina; composicion farmaceutica y cosmetica y el uso de los mismos para la preparacion de un medicamento.
ES2176343T3 (es) Composiciones sanadoras de tratamiento de heridas causadas por el acne que contienen un piruvano, un antioxidante y una mezcla de acidos grasos.
PT1175214E (pt) Composicoes de inibidor de ciclo-oxigenase-2 com um inicio rapido do seu efito terapeutico
ES2152556T3 (es) Composiciones que contienen derivados del acido hidroperoxieicosatetraenoico y procedimientos de utilizacion en el tratamiento de trastornos de la sequedad ocular.
ES2183937T3 (es) Inhibidores de la adhesion celular.
AR008164A1 (es) Cetolidas 6-0-sustituidas que tienen actividad antibacteriana, procedimientos para su preparacion, uso de los mismos en la preparacion decomposiciones farmaceuticas y composiciones farmaceuticas
YU48416B (sh) Novi derivati hidroksamske kiseline i n-hidroksikarbamida i postupci za njihovo dobijanje
AR029383A1 (es) Moleculas pequenas, los intermediarios para su sintesis, las composiciones farmaceuticas que las contienen y su uso para preparar un medicamento destinado al tratamiento o la profilaxis de enfermedades inflamatorias o mediadas por celulas inmunes
ES2157601T3 (es) Uso de agentes anti-microtubulos para tratar o prevenir la esclerosis multiple.
MX9301348A (es) Nuevos compuestos que tienen actividad farmacologica, proceso para su preparacion y composicion farmaceutica que los comprende.
ES2072323T3 (es) Compuestos de piperidina y su preparacion y empleo.
HRP20060275B1 (hr) 6-0-supstituirani ketolidi antibakterijskog djelovanja
PA8489501A1 (es) Antibioticos cetolidos
DOP2001000233A (es) Compuestos farmacéuticos
DE69722434D1 (de) Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen
ES2174921T3 (es) Inhibidores de la proteasa del vih.
AR007021A1 (es) Derivados de 3-descladinosa-2,3-anhidroeritromicina, procedimientos para su preparacion, compuestos para su exclusivo uso en dichos procedimientosy procedimiento para su preparacion, una composicion farmaceutica para tratar infecciones bacterianas y el uso de estos compuestos para preparar medicamentos
MX9205123A (es) Derivados de 5-hidroxi-2-pirimidinilmetileno utiles como agentes anti-inflamatorios.
ATE340561T1 (de) Verwendung von antiseptika zur herstellung von arzneimitteln zur prophylaxe und behandlung von entzündungen im korperinneren des menschen
UY26895A1 (es) Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 827514

Country of ref document: ES