ITPD950090A0 - Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici - Google Patents

Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici

Info

Publication number
ITPD950090A0
ITPD950090A0 ITPD950090A ITPD950090A ITPD950090A0 IT PD950090 A0 ITPD950090 A0 IT PD950090A0 IT PD950090 A ITPD950090 A IT PD950090A IT PD950090 A ITPD950090 A IT PD950090A IT PD950090 A0 ITPD950090 A0 IT PD950090A0
Authority
IT
Italy
Prior art keywords
succinil
therapeutic agents
metal salts
heavy metal
hyaluronic acid
Prior art date
Application number
ITPD950090A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITPD950090A0 publication Critical patent/ITPD950090A0/it
Priority to IT95PD000090A priority Critical patent/IT1281877B1/it
Priority to AU58944/96A priority patent/AU695512B2/en
Priority to CA002220682A priority patent/CA2220682C/en
Priority to ES96916030T priority patent/ES2137694T3/es
Priority to PCT/EP1996/001979 priority patent/WO1996035720A1/en
Priority to JP53376996A priority patent/JP4264671B2/ja
Priority to DE69603721T priority patent/DE69603721T2/de
Priority to AT96916030T priority patent/ATE183206T1/de
Priority to EP96916030A priority patent/EP0827514B1/en
Publication of ITPD950090A1 publication Critical patent/ITPD950090A1/it
Priority to US08/966,636 priority patent/US6017901A/en
Application granted granted Critical
Publication of IT1281877B1 publication Critical patent/IT1281877B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
IT95PD000090A 1995-05-10 1995-05-10 Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici IT1281877B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT95PD000090A IT1281877B1 (it) 1995-05-10 1995-05-10 Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
PCT/EP1996/001979 WO1996035720A1 (en) 1995-05-10 1996-05-08 Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions
CA002220682A CA2220682C (en) 1995-05-10 1996-05-08 Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions
ES96916030T ES2137694T3 (es) 1995-05-10 1996-05-08 Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas.
AU58944/96A AU695512B2 (en) 1995-05-10 1996-05-08 Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions
JP53376996A JP4264671B2 (ja) 1995-05-10 1996-05-08 ヒアルロン酸との又はヒアルロン酸エステルとのコハク酸ヘミエステルの重金属塩類、それらの製造方法及びその医薬組成物
DE69603721T DE69603721T2 (de) 1995-05-10 1996-05-08 Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen
AT96916030T ATE183206T1 (de) 1995-05-10 1996-05-08 Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen
EP96916030A EP0827514B1 (en) 1995-05-10 1996-05-08 Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions
US08/966,636 US6017901A (en) 1995-05-10 1997-11-10 Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95PD000090A IT1281877B1 (it) 1995-05-10 1995-05-10 Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici

Publications (3)

Publication Number Publication Date
ITPD950090A0 true ITPD950090A0 (it) 1995-05-10
ITPD950090A1 ITPD950090A1 (it) 1996-11-10
IT1281877B1 IT1281877B1 (it) 1998-03-03

Family

ID=11391041

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95PD000090A IT1281877B1 (it) 1995-05-10 1995-05-10 Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici

Country Status (9)

Country Link
EP (1) EP0827514B1 (it)
JP (1) JP4264671B2 (it)
AT (1) ATE183206T1 (it)
AU (1) AU695512B2 (it)
CA (1) CA2220682C (it)
DE (1) DE69603721T2 (it)
ES (1) ES2137694T3 (it)
IT (1) IT1281877B1 (it)
WO (1) WO1996035720A1 (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69632996T2 (de) * 1995-12-26 2005-07-21 Toyo Boseki K.K. In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
IT1294797B1 (it) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante
US6872819B1 (en) * 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) * 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
JP2003089647A (ja) * 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
IL146795A0 (en) * 1999-06-18 2002-07-25 Ml Lab Plc Biologically active materials
CA2495541C (en) 2002-09-11 2011-07-12 Johnson & Johnson Medical Limited Wound dressing materials comprising complexes of anionic polysaccharides with silver
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
DK200301128A (da) * 2003-08-05 2005-02-06 Thomsen Joern Oddershede Tilskudspræparat
US7993678B2 (en) 2005-09-26 2011-08-09 Novozymes Biopolymer A/S Hyaluronic acid derivatives
IT1402786B1 (it) * 2010-11-19 2013-09-18 Fidia Farmaceutici Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
WO2015128787A1 (en) 2014-02-27 2015-09-03 Pharmalink Ab Hyaluronan conjugates with pharmaceutically active substances, methods and compositions
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
MA41912A (fr) * 2015-04-07 2018-02-13 Hyalblue S R L Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
WO2019121488A1 (en) * 2017-12-21 2019-06-27 Nicox S.A. Nitric oxide releasing hyaluronic esters
JP7066909B1 (ja) * 2020-12-25 2022-05-13 参天製薬株式会社 高分子化合物、銀塩およびイオン性等張化剤を含有する水性点眼液
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
IT202200004613A1 (it) 2022-03-10 2023-09-10 Cmed Aesthetics S R L “procedimento di preparazione di prodotti sterili”
WO2024038088A1 (en) 2022-08-16 2024-02-22 Synartro Ab Liquid formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5436388A (en) * 1977-08-26 1979-03-17 Sumitomo Electric Ind Ltd Porous polysaccharide and its preparation
DE3273138D1 (en) * 1981-06-02 1986-10-16 Eupan Corp Eustatic composition for nonspecifically facilitating and amplifying the generalized homeostatic regulation and maintenance, compensation and repair in living organisms
CA1291034C (en) * 1987-10-19 1991-10-22 Mostafa S. Fahim Composition for promoting epithelial regeneration
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents

Also Published As

Publication number Publication date
WO1996035720A1 (en) 1996-11-14
DE69603721D1 (de) 1999-09-16
DE69603721T2 (de) 2000-01-13
AU695512B2 (en) 1998-08-13
ES2137694T3 (es) 1999-12-16
EP0827514A1 (en) 1998-03-11
JPH11504668A (ja) 1999-04-27
EP0827514B1 (en) 1999-08-11
CA2220682C (en) 2006-10-24
CA2220682A1 (en) 1996-11-14
IT1281877B1 (it) 1998-03-03
AU5894496A (en) 1996-11-29
ITPD950090A1 (it) 1996-11-10
JP4264671B2 (ja) 2009-05-20
ATE183206T1 (de) 1999-08-15

Similar Documents

Publication Publication Date Title
ITPD950090A0 (it) Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
ITMI981836A0 (it) Nuovi derivati dell'acido ialuronico
IT8820859A0 (it) Impiego di sali dell'acido gamma idrossi butirrico per lapreparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell'alcolismo e composizioni relative.
ITMI941291A0 (it) Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
ITPD950101A0 (it) Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro im- piego in campo biomedico sanitario
ITMI942156A0 (it) Derivati dell'acido p-amminopropionico ad attivita' fungicida
ITPD970253A0 (it) Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario
ITRM950557A0 (it) Metodo per determinare l'attivita' terapeutica di composti inibitori di metalloproteinasi, nuovi composti inibitori, e loro impiego terapeutico
ITPD920146A0 (it) Nuovi derivati dell'acido neuraminico
IT1273471B (it) Derivati dell'acido kojico
IT8748404A0 (it) O-alcanoil derivati dell'acido 3ammino-2-idrossipropansolfonico adattivita'anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico dell'epilessia
ITMI942319A0 (it) Nuovi derivati dell'acido kojico
IT8248399A0 (it) Derivati dell'acido 2-ammino triazolil 2-ossiimino acetammido bicicloottene carbossilico dotati di attivita' farmacologica e procedimento per la loro preparazione
ITMI940826A0 (it) Dispersioni di sali di polimeri o copolimeri dell'acido acrilico e loro uso come agenti addensanti
IT8919401A0 (it) Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
ITRM920039A0 (it) Uso dell'acido ialuronico lubrificante di protesi oculari.
ITMI931808A0 (it) Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico
ITMI910581A1 (it) Derivati dell'acido 5-fenil-1h-pirazol-4-propionico, loro preparazione e loro impiego come medicamenti
ITMI931658A1 (it) Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenioco e loro uso nella sintesi di cefalosporine
ITMI941955A0 (it) "sintesi quantitativa dell'acido 3-(l-piroglutamil)-l-tiazolidin-4- carbossilico e suoi derivati"
ITMI951297A0 (it) Processo per la preparazione di derivati dell'acido-metil-2- tiofeneacetico
ITMI930749A0 (it) Derivato dell'acido iodesossicolico
ITMI950780A0 (it) Estere chinolonico di derivati dell'acido 3-cefem-4-carbossilico
ITMI930524A1 (it) Derivati dell'acido ursodesossicolico e loro preparazione
ITMI941554A0 (it) Derivati dell'acido 2-(2-azetidinon-n-il)-3-butenoico e loro uso nella sintesi di cefalosporine

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990614