ES2137191T3 - Metodos para ensayos de luminiscencia mejorados que usan concentracion de particulas y deteccion de la quimioluminiscencia. - Google Patents

Metodos para ensayos de luminiscencia mejorados que usan concentracion de particulas y deteccion de la quimioluminiscencia.

Info

Publication number
ES2137191T3
ES2137191T3 ES92916043T ES92916043T ES2137191T3 ES 2137191 T3 ES2137191 T3 ES 2137191T3 ES 92916043 T ES92916043 T ES 92916043T ES 92916043 T ES92916043 T ES 92916043T ES 2137191 T3 ES2137191 T3 ES 2137191T3
Authority
ES
Spain
Prior art keywords
chemioluminiscence
detection
analyte
sample
test methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916043T
Other languages
English (en)
Inventor
Richard J Massey
Gary F Blackburn
Elizabeth W Kenten
Haresh P Shah
Jonathan K Leland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IGEN International Inc
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Application granted granted Critical
Publication of ES2137191T3 publication Critical patent/ES2137191T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)

Abstract

LO QUE SE DESCRIBEN SON METODOS Y APARATOS PARA REALIZAR UN ENSAYO DE ENLACE PARA UN PRODUCTO DE ANALISIS DE INTERES PRESENTE EN UNA MUESTRA.EL METODO COMPRENDE LOS PASOS DE: FORMAR UNA COMPOSICION QUE CONTIENE LA MUESTRA; UNA SUSTANCIA DE REALIZACION DE ENSAYO QUE CONTIENE UN COMPONENTE ENLAZADO A UN COMPUESTO DE ETIQUETA CAPAZ DE CHIMILUMINISCENCIA CUANDO SE DISPARA, Y UNA PLURALIDAD DE PARTICULAS CAPACES DE ENLAZARSE ESPECIFICAMENTE CON EL PRODUCTOS DE ANALISIS Y/O LA SUSTANCIA DE REALIZACION DE ENSAYO; INCUBAR LA COMPOSICION PARA FORMAR UN COMPLEJO QUE COMPRENDE UN COMPONENTE ETIQUETADO DE PARTICULAS; RECOGER EL COMPLEJO EN UNA ZONA DE RECOGIDA; INTRODUCIR DENTRO DE LA ZONA DE RECOGIDA UN GATILLO CAPAZ DE DISPARAR LA ETIQUETA DE MANERA QUE LA ETIQUETA SE ILUMINE; Y MEDIR LA LUMINISCENCIA EMITIDA PARA MEDIR LA PRESENCIA DEL PRODUCTO DE ANALISIS DE INTERES EN LA MUESTRA.
ES92916043T 1991-07-10 1992-07-10 Metodos para ensayos de luminiscencia mejorados que usan concentracion de particulas y deteccion de la quimioluminiscencia. Expired - Lifetime ES2137191T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72809391A 1991-07-10 1991-07-10
US72819491A 1991-07-10 1991-07-10

Publications (1)

Publication Number Publication Date
ES2137191T3 true ES2137191T3 (es) 1999-12-16

Family

ID=27111631

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916043T Expired - Lifetime ES2137191T3 (es) 1991-07-10 1992-07-10 Metodos para ensayos de luminiscencia mejorados que usan concentracion de particulas y deteccion de la quimioluminiscencia.

Country Status (9)

Country Link
EP (2) EP0594766B1 (es)
JP (1) JP3053112B2 (es)
KR (1) KR100212178B1 (es)
AT (1) ATE184320T1 (es)
CA (1) CA2112675C (es)
DE (1) DE69229950T2 (es)
ES (1) ES2137191T3 (es)
GR (1) GR3031217T3 (es)
WO (1) WO1993001308A1 (es)

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JP3207933B2 (ja) * 1992-09-09 2001-09-10 株式会社ヤトロン アクリジニウム誘導体の発光方法及びそれを用いた検査対象物質の検出方法
US5466416A (en) * 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
DE19501916A1 (de) * 1994-01-24 1995-07-27 Hitachi Ltd Verfahren und Analysator zum Immuntest unter Verwendung magnetischer Teilchen
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
JP4643008B2 (ja) * 1999-01-18 2011-03-02 プレシジョン・システム・サイエンス株式会社 磁性粒子を利用した濃縮装置およびその方法
EP1360488B1 (en) * 2000-07-26 2016-04-13 ChemoMetec A/S Spatially resolved enzyme-linked assay
DE10058095C2 (de) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Vorrichtung zur Bestimmung von Analyten durch Chemilumineszenz
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
AT413153B (de) * 2004-03-11 2005-11-15 Christian Doppler Labor Fuer S Verfahren und vorrichtung zur detektion von markierten mikropartikeln
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
JP2006255817A (ja) * 2005-03-16 2006-09-28 Sonac Kk 金属構造およびその製造方法
CA2609379C (en) 2005-06-03 2016-11-29 Allen J. Bard Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
EP1910832A1 (en) * 2005-07-20 2008-04-16 Inverness Medical Switzerland GmbH Assay device and method
EP2720798B1 (en) * 2011-06-15 2020-01-01 Koninklijke Philips N.V. Processing of biological sample components
WO2016091755A1 (en) 2014-12-08 2016-06-16 F. Hoffmann-La Roche Ag Method for measurement of vitamin d
CN104917178B (zh) * 2015-05-29 2017-02-01 太原理工大学 一种减小三电平并联型有源电力滤波器死区效应的方法
CN105067602B (zh) * 2015-07-16 2017-08-25 重庆大学 一种铜离子检测试纸及用于检测水中铜离子的方法
CN110170344A (zh) * 2019-05-31 2019-08-27 深圳市亚辉龙生物科技股份有限公司 微流控芯片及检测装置

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Also Published As

Publication number Publication date
EP0594766B1 (en) 1999-09-08
GR3031217T3 (en) 1999-12-31
DE69229950D1 (de) 1999-10-14
EP0854194A2 (en) 1998-07-22
DE69229950T2 (de) 2000-03-09
EP0594766A1 (en) 1994-05-04
KR100212178B1 (ko) 1999-08-02
AU2347892A (en) 1993-02-11
AU676665B2 (en) 1997-03-20
JPH07508340A (ja) 1995-09-14
ATE184320T1 (de) 1999-09-15
CA2112675C (en) 2007-03-20
CA2112675A1 (en) 1993-01-21
EP0594766A4 (en) 1996-08-21
EP0854194A3 (en) 1998-08-05
WO1993001308A1 (en) 1993-01-21
JP3053112B2 (ja) 2000-06-19

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