ES2136285T3 - Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii). - Google Patents
Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii).Info
- Publication number
- ES2136285T3 ES2136285T3 ES95914256T ES95914256T ES2136285T3 ES 2136285 T3 ES2136285 T3 ES 2136285T3 ES 95914256 T ES95914256 T ES 95914256T ES 95914256 T ES95914256 T ES 95914256T ES 2136285 T3 ES2136285 T3 ES 2136285T3
- Authority
- ES
- Spain
- Prior art keywords
- icerel
- cdna
- recombinant
- interleukin
- precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 title 1
- 101000870333 Dictyostelium discoideum Cysteine proteinase 3 Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000003777 Interleukin-1 beta Human genes 0.000 title 1
- 108090000193 Interleukin-1 beta Proteins 0.000 title 1
- 101000870331 Vasconcellea cundinamarcensis Cysteine proteinase 2 Proteins 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 108020004635 Complementary DNA Proteins 0.000 abstract 6
- 238000010804 cDNA synthesis Methods 0.000 abstract 6
- 239000002299 complementary DNA Substances 0.000 abstract 6
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 2
- 230000006870 function Effects 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE IDENTIFICA, SECUENCIA Y AISLA UN ADN COMPLEMENTARIO (ADNC) QUE CODIFICA LA FORMA DE LONGITUD COMPLETA DE ICE{SUB,REL}-II. EL ADNC SE CLONA PARA OBTENER VECTORES DE EXPRESION PARA LA EXPRESION EN HUESPEDES RECOMBINANTES. EL ADNC ES UTIL PARA PRODUCIR ICE{SUB,REL}-II RECOMBINANTE DE LONGITUD COMPLETA. EL ADNC Y LA PROTEINA RECOMBINANTE ICE{SUB,REL}-II DERIVADA DE MISMO SON UTILES EN EQUIPOS DE DIAGNOSTICO, EN REACTIVOS Y ENSAYOS DE LABORATORIO. EL CDNA Y LA PROTEINA RECOMBINANTE ICE{SUB,REL}-II PUEDEN UTILIZARSE PARA IDENTIFICAR COMPUESTOS QUE AFECTEN A LA FUNCION DE ICE{SUB,REL}-II, A LA INFLAMACION Y A LA APOPTOSIS CELULAR. LA FUNCION DE LA PROTEINA ICE{SUB,REL}-II, LA INFLAMACION Y LA APOPTOSIS CELULAR PUEDEN MODULARSE TAMBIEN MEDIANTE TERAPIA GENETICA Y ICE{SUB,REL}-II DE ANTISENTIDO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/225,487 US6110701A (en) | 1994-04-08 | 1994-04-08 | DNA encoding precursor of interleukin-1β converting enzyme--related cysteine proteinase II (ICErel -II) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2136285T3 true ES2136285T3 (es) | 1999-11-16 |
Family
ID=22845077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95914256T Expired - Lifetime ES2136285T3 (es) | 1994-04-08 | 1995-04-04 | Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii). |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6110701A (es) |
| EP (1) | EP0754234B1 (es) |
| JP (1) | JP3750136B2 (es) |
| AT (1) | ATE182176T1 (es) |
| CA (1) | CA2187161C (es) |
| DE (1) | DE69510782T2 (es) |
| DK (1) | DK0754234T3 (es) |
| ES (1) | ES2136285T3 (es) |
| GR (1) | GR3031468T3 (es) |
| WO (1) | WO1995027793A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7250494A (en) * | 1994-06-23 | 1996-01-19 | Human Genome Sciences, Inc. | Interleukin-1 beta converting enzyme like apoptosis protease-1 and 2 |
| FR2723378B1 (fr) * | 1994-08-02 | 1996-10-31 | Roussel Uclaf | Sequence d'adn codant pour une proteine humaine tx apparentee a l'enzyme de conversion de l'interleukine-1beta, proteine tx, procede de production, compositions pharmaceutiques et leurs applications |
| WO1996026280A1 (en) * | 1995-02-21 | 1996-08-29 | Basf Aktiengesellschaft | NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME |
| US6121018A (en) * | 1997-03-27 | 2000-09-19 | Smithkline Beecham Corporation | Interleukin-1β converting enzyme like apoptosis protease-10 |
| PL366134A1 (en) | 2000-06-15 | 2005-01-24 | Smithkline Beecham Corporation | Method for preparing a physiologically active il-18 polypeptide |
| CN115772220B (zh) * | 2022-11-22 | 2023-08-11 | 武汉爱博泰克生物科技有限公司 | 针对人白介素-1β的兔单克隆抗体及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5416013A (en) * | 1990-04-04 | 1995-05-16 | Sterling Winthrop Inc. | Interleukin 1β protease and interleukin 1β protease inhibitors |
| WO1993025685A1 (en) * | 1992-06-12 | 1993-12-23 | Massachusetts Institute Of Technology | Cloning and characterization of the cell death genes ced-3 and ced-4 |
| JPH08500482A (ja) * | 1992-06-12 | 1996-01-23 | マサチューセッツ インスティテュート オブ テクノロジー | Ｃｅｄ−３及び関連蛋白質のインヒビター |
-
1994
- 1994-04-08 US US08/225,487 patent/US6110701A/en not_active Expired - Fee Related
-
1995
- 1995-04-04 DE DE69510782T patent/DE69510782T2/de not_active Expired - Lifetime
- 1995-04-04 AT AT95914256T patent/ATE182176T1/de not_active IP Right Cessation
- 1995-04-04 EP EP95914256A patent/EP0754234B1/en not_active Expired - Lifetime
- 1995-04-04 ES ES95914256T patent/ES2136285T3/es not_active Expired - Lifetime
- 1995-04-04 WO PCT/CA1995/000188 patent/WO1995027793A1/en not_active Ceased
- 1995-04-04 US US08/721,986 patent/US6103513A/en not_active Expired - Fee Related
- 1995-04-04 CA CA002187161A patent/CA2187161C/en not_active Expired - Fee Related
- 1995-04-04 DK DK95914256T patent/DK0754234T3/da active
- 1995-04-04 JP JP52599295A patent/JP3750136B2/ja not_active Expired - Fee Related
-
1999
- 1999-10-08 GR GR990402559T patent/GR3031468T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69510782D1 (de) | 1999-08-19 |
| DE69510782T2 (de) | 1999-12-30 |
| US6110701A (en) | 2000-08-29 |
| JP3750136B2 (ja) | 2006-03-01 |
| CA2187161C (en) | 2008-02-05 |
| ATE182176T1 (de) | 1999-07-15 |
| DK0754234T3 (da) | 1999-11-29 |
| JPH09511646A (ja) | 1997-11-25 |
| WO1995027793A1 (en) | 1995-10-19 |
| EP0754234B1 (en) | 1999-07-14 |
| CA2187161A1 (en) | 1995-10-19 |
| GR3031468T3 (en) | 2000-01-31 |
| EP0754234A1 (en) | 1997-01-22 |
| US6103513A (en) | 2000-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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