ES2136285T3 - Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii). - Google Patents

Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii).

Info

Publication number
ES2136285T3
ES2136285T3 ES95914256T ES95914256T ES2136285T3 ES 2136285 T3 ES2136285 T3 ES 2136285T3 ES 95914256 T ES95914256 T ES 95914256T ES 95914256 T ES95914256 T ES 95914256T ES 2136285 T3 ES2136285 T3 ES 2136285T3
Authority
ES
Spain
Prior art keywords
icerel
cdna
recombinant
interleukin
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914256T
Other languages
English (en)
Inventor
Donald W Nicholson
Ambereen Ali
Neil A Munday
John P Vaillancourt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of ES2136285T3 publication Critical patent/ES2136285T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE IDENTIFICA, SECUENCIA Y AISLA UN ADN COMPLEMENTARIO (ADNC) QUE CODIFICA LA FORMA DE LONGITUD COMPLETA DE ICE{SUB,REL}-II. EL ADNC SE CLONA PARA OBTENER VECTORES DE EXPRESION PARA LA EXPRESION EN HUESPEDES RECOMBINANTES. EL ADNC ES UTIL PARA PRODUCIR ICE{SUB,REL}-II RECOMBINANTE DE LONGITUD COMPLETA. EL ADNC Y LA PROTEINA RECOMBINANTE ICE{SUB,REL}-II DERIVADA DE MISMO SON UTILES EN EQUIPOS DE DIAGNOSTICO, EN REACTIVOS Y ENSAYOS DE LABORATORIO. EL CDNA Y LA PROTEINA RECOMBINANTE ICE{SUB,REL}-II PUEDEN UTILIZARSE PARA IDENTIFICAR COMPUESTOS QUE AFECTEN A LA FUNCION DE ICE{SUB,REL}-II, A LA INFLAMACION Y A LA APOPTOSIS CELULAR. LA FUNCION DE LA PROTEINA ICE{SUB,REL}-II, LA INFLAMACION Y LA APOPTOSIS CELULAR PUEDEN MODULARSE TAMBIEN MEDIANTE TERAPIA GENETICA Y ICE{SUB,REL}-II DE ANTISENTIDO.
ES95914256T 1994-04-08 1995-04-04 Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii). Expired - Lifetime ES2136285T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/225,487 US6110701A (en) 1994-04-08 1994-04-08 DNA encoding precursor of interleukin-1β converting enzyme--related cysteine proteinase II (ICErel -II)

Publications (1)

Publication Number Publication Date
ES2136285T3 true ES2136285T3 (es) 1999-11-16

Family

ID=22845077

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914256T Expired - Lifetime ES2136285T3 (es) 1994-04-08 1995-04-04 Adn que codifica el precursor de la proteinasa ii de cisteina relacionada con la enzima convertidora de interleucina 1-beta (icerel-ii).

Country Status (10)

Country Link
US (2) US6110701A (es)
EP (1) EP0754234B1 (es)
JP (1) JP3750136B2 (es)
AT (1) ATE182176T1 (es)
CA (1) CA2187161C (es)
DE (1) DE69510782T2 (es)
DK (1) DK0754234T3 (es)
ES (1) ES2136285T3 (es)
GR (1) GR3031468T3 (es)
WO (1) WO1995027793A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000297A1 (en) * 1994-06-23 1996-01-04 Human Genome Sciences, Inc. INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-1 AND 2
FR2723378B1 (fr) * 1994-08-02 1996-10-31 Roussel Uclaf Sequence d'adn codant pour une proteine humaine tx apparentee a l'enzyme de conversion de l'interleukine-1beta, proteine tx, procede de production, compositions pharmaceutiques et leurs applications
WO1996026280A1 (en) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME
US6121018A (en) * 1997-03-27 2000-09-19 Smithkline Beecham Corporation Interleukin-1β converting enzyme like apoptosis protease-10
AU2001280442B2 (en) 2000-06-15 2005-10-27 Smithkline Beecham Corporation Method for preparing a physiologically active il-18 polypeptide
CN115772220B (zh) * 2022-11-22 2023-08-11 武汉爱博泰克生物科技有限公司 针对人白介素-1β的兔单克隆抗体及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416013A (en) * 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
WO1993025685A1 (en) * 1992-06-12 1993-12-23 Massachusetts Institute Of Technology Cloning and characterization of the cell death genes ced-3 and ced-4
EP0672151A1 (en) * 1992-06-12 1995-09-20 Massachusetts Institute Of Technology Inhibitors of ced-3 and related proteins

Also Published As

Publication number Publication date
JPH09511646A (ja) 1997-11-25
GR3031468T3 (en) 2000-01-31
WO1995027793A1 (en) 1995-10-19
EP0754234B1 (en) 1999-07-14
CA2187161A1 (en) 1995-10-19
EP0754234A1 (en) 1997-01-22
ATE182176T1 (de) 1999-07-15
JP3750136B2 (ja) 2006-03-01
CA2187161C (en) 2008-02-05
DE69510782D1 (de) 1999-08-19
US6110701A (en) 2000-08-29
US6103513A (en) 2000-08-15
DE69510782T2 (de) 1999-12-30
DK0754234T3 (da) 1999-11-29

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