ES2135564T3 - Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. - Google Patents

Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina.

Info

Publication number
ES2135564T3
ES2135564T3 ES94908221T ES94908221T ES2135564T3 ES 2135564 T3 ES2135564 T3 ES 2135564T3 ES 94908221 T ES94908221 T ES 94908221T ES 94908221 T ES94908221 T ES 94908221T ES 2135564 T3 ES2135564 T3 ES 2135564T3
Authority
ES
Spain
Prior art keywords
proteins
fibronectin
factor xiii
biological adhesive
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908221T
Other languages
English (en)
Inventor
Trung Bui-Khac
Lise Lavoie
St Picq Dominique Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HAEMACURE CORP CORP HAEMACURE
Haemacure Corp Canada
Original Assignee
HAEMACURE CORP CORP HAEMACURE
Haemacure Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25683079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2135564(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by HAEMACURE CORP CORP HAEMACURE, Haemacure Corp Canada filed Critical HAEMACURE CORP CORP HAEMACURE
Application granted granted Critical
Publication of ES2135564T3 publication Critical patent/ES2135564T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA FABRICAR UN CONCENTRADO DE PROTEINAS DE COAGULACION EMPEZANDO CON PLASMA DE HUMANO O ANIMAL INTEGRO. ESTE CONCENTRADO SE USA COMO UN ADHESIVO BIOLOGICO CUANDO SE MEZCLA EXTEMPORANEAMENTE CON TROMBINA. LAS PROTEINAS CONCENTRADAS INCLUYEN PRINCIPALMENTE PARTE FIBRINOGENO, UN FACTOR ESTABILIZADOR DE FIBRINA (FACTOR XIII) Y FIBRONECTINA. EL PROCESO PRESENTADO TIENE LA VENTAJA DE SER DE CORTA EJECUCION, MIENTRAS QUE SUMINISTRA UNA PRODUCCION EXCELENTE DE PROTEINAS COAGULABLES. NINGUN INHIBIDOR DE PROTEASA TIENE QUE SER AÑADIDO DURANTE EL PROCESO. EL PROCESO IMPLICA ETAPAS DE SEPARACION POR DESALADO EN PRESENCIA DE ACIDO AMINO-6 HEXANOICO QUE EVITA LA COPRECIPITACION DE PLASMINOGENO CON LAS PROTEINAS COAGULABLES DESEADAS. LAS PROTEINAS ASI OBTENIDAS SON MUY ESTABLES DESPUES DE SU RECONSTITUCION EN AGUA DURANTE AL MENOS 24 HORAS A TEMPERATURA AMBIENTE O CORPORAL. DESPUES SU MEZCLA CON TROMBINA Y CALCIO, EL ADHESIVO MUESTRA EXCELENTE RESISTENCIA YBIOCOMPATIBILIDAD
ES94908221T 1993-02-23 1994-02-28 Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina. Expired - Lifetime ES2135564T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/021,302 US5395923A (en) 1993-02-23 1993-02-23 Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"
PCT/CA1994/000105 WO1995023167A1 (en) 1993-02-23 1994-02-28 Process for the obtention of a biological adhesive comprising fibrinogen, factor xiii and fibronectin

Publications (1)

Publication Number Publication Date
ES2135564T3 true ES2135564T3 (es) 1999-11-01

Family

ID=25683079

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908221T Expired - Lifetime ES2135564T3 (es) 1993-02-23 1994-02-28 Procedimiento para la obtencion de un adhesivo biologico que comprende fibrinogeno, factor xiii y fibronectina.

Country Status (12)

Country Link
US (1) US5395923A (es)
EP (1) EP0748337B1 (es)
JP (1) JP3492694B2 (es)
AT (1) ATE181738T1 (es)
AU (1) AU678439B2 (es)
CA (1) CA2113660C (es)
DE (1) DE69419324T2 (es)
DK (1) DK0748337T3 (es)
ES (1) ES2135564T3 (es)
NO (1) NO317699B1 (es)
RU (1) RU2130946C1 (es)
WO (1) WO1995023167A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
WO1996022115A1 (en) * 1995-01-16 1996-07-25 Baxter International Inc. Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions
JPH08333277A (ja) * 1995-06-05 1996-12-17 Hoechst Japan Ltd ヒト血液凝固第ｘｉｉｉ因子の安定化された水性液製剤
EP0917444A1 (en) 1996-07-12 1999-05-26 Baxter Travenol Laboratories, Inc. A fibrin delivery device and method for forming fibrin on a surface
US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
WO1998030304A1 (en) * 1997-01-08 1998-07-16 Bristol-Myers Squibb Company A centrifuge apparatus with temperature control means
US6132598A (en) * 1997-01-08 2000-10-17 Bristol-Myers Squibb Company Centrifuge apparatus with temperature control means
KR100564189B1 (ko) 1997-04-28 2006-03-27 일라이 릴리 앤드 캄파니 활성화 프로틴ｃ의 가공을 위한 개선된 방법
US6630137B1 (en) * 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
US5900270A (en) * 1997-09-22 1999-05-04 Cobe Laboratories, Inc. Technique for testing and coating a microporous membrane
US5981254A (en) * 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
US6503527B1 (en) * 1997-11-17 2003-01-07 Haemacure Corporation Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6310036B1 (en) 1999-01-09 2001-10-30 Last Chance Tissue Adhesives Corporation High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
JP4771594B2 (ja) * 1999-02-12 2011-09-14 バクスター アクチェンゲゼルシャフト フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物
SI1151007T1 (sl) * 1999-02-12 2006-10-31 Baxter Ag Postopek za pripravo pripravka na osnovi fibrinogena in fibronektina in proteinski sestavki, ki jihlahko dobimo po tem postopku
US6610043B1 (en) 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US7654998B1 (en) 1999-08-23 2010-02-02 Aeris Therapeutics, Inc. Tissue volume reduction
NZ518692A (en) 1999-12-23 2004-08-27 Csl Ltd Purified fibrinogen free of destabilising levels of plasminogen and other proteases obtained from a Fraction I paste
US7204981B2 (en) * 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
WO2001089558A2 (en) 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
JP2005528351A (ja) * 2002-03-08 2005-09-22 イーライ・リリー・アンド・カンパニー 活性化プロテインｃ製剤
US7374678B2 (en) * 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7179391B2 (en) * 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
GB0216001D0 (en) 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US9358318B2 (en) 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
JP5133061B2 (ja) * 2004-10-20 2013-01-30 エシコン・インコーポレイテッド 強化された吸収性複層の止血用創傷手当て用品および製造方法
US20060258995A1 (en) * 2004-10-20 2006-11-16 Pendharkar Sanyog M Method for making a reinforced absorbable multilayered fabric for use in medical devices
EP2666493B1 (en) 2005-02-07 2020-09-23 Hanuman LLC Platelet rich plasma concentrate apparatus
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
WO2006086201A2 (en) * 2005-02-07 2006-08-17 Hanuman Llc Platelet rich plasma concentrate apparatus and method
CN1911440A (zh) * 2005-08-08 2007-02-14 上海莱士血制品有限公司 一种用于形成纤维蛋白膜的试剂盒及其应用
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8430813B2 (en) * 2006-05-26 2013-04-30 Depuy Spine, Inc. Illuminated surgical access system including a surgical access device and integrated light emitter
EP2121057A4 (en) * 2007-02-06 2012-10-10 Incept Llc POLYMERIZATION WITH PRECIPITATION OF PROTEINS FOR ELUTION IN A PHYSIOLOGICAL SOLUTION
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US7806276B2 (en) * 2007-04-12 2010-10-05 Hanuman, Llc Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
EP2567692B1 (en) 2008-02-27 2016-04-06 Biomet Biologics, LLC Use of a device for obtaining interleukin-1 receptor antagonist rich solutions
US8337711B2 (en) * 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8012077B2 (en) * 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
EP2396070A4 (en) 2009-02-12 2012-09-19 Incept Llc ACTIVE COMPOSITION WITH HYDROGEL PLUGS
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) * 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
RU2561676C1 (ru) * 2014-04-07 2015-08-27 Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации Способ получения клеящей массы
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2826533A (en) * 1954-03-15 1958-03-11 Cutter Lab Stable fibrinogen solutions and method for producing same
JPS5598196A (en) * 1979-01-16 1980-07-25 Meito Sangyo Kk Fractionation of fibrinogen or its constituents and their use
AT359652B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT390001B (de) * 1984-09-28 1990-03-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern
DE3622642A1 (de) * 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
FR2618784B1 (fr) * 1987-07-30 1990-04-06 Lille Transfusion Sanguine Concentre de proteines coagulables par la thrombine, son procede d'obtention et son utilisation a titre de colle biologique
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
US5030215A (en) * 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
AU1461592A (en) * 1991-02-07 1992-09-07 Fibratek, Inc. Fibrinogen based adhesive
EP0534178B1 (en) * 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Improved tissue glue prepared by using cryoprecipitate
US5290918A (en) * 1993-02-23 1994-03-01 Haemacure Biotech Inc. Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation

Also Published As

Publication number Publication date
NO317699B1 (no) 2004-12-06
JPH09509183A (ja) 1997-09-16
DE69419324D1 (de) 1999-08-05
JP3492694B2 (ja) 2004-02-03
WO1995023167A1 (en) 1995-08-31
AU678439B2 (en) 1997-05-29
NO963602L (no) 1996-10-17
RU2130946C1 (ru) 1999-05-27
DE69419324T2 (de) 2000-03-02
AU6151594A (en) 1995-09-11
NO963602D0 (no) 1996-08-28
EP0748337A1 (en) 1996-12-18
DK0748337T3 (da) 2000-01-17
CA2113660A1 (en) 1994-08-24
US5395923A (en) 1995-03-07
ATE181738T1 (de) 1999-07-15
CA2113660C (en) 2000-05-16
EP0748337B1 (en) 1999-06-30

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