NO317699B1 - Fremgangsmate for fremstilling av et proteinkonsentrat som er koagulerbar med trombin, og som inneholder for det meste fibrinogen, endogen faktor XIII og fibronektin. - Google Patents
Fremgangsmate for fremstilling av et proteinkonsentrat som er koagulerbar med trombin, og som inneholder for det meste fibrinogen, endogen faktor XIII og fibronektin. Download PDFInfo
- Publication number
- NO317699B1 NO317699B1 NO19963602A NO963602A NO317699B1 NO 317699 B1 NO317699 B1 NO 317699B1 NO 19963602 A NO19963602 A NO 19963602A NO 963602 A NO963602 A NO 963602A NO 317699 B1 NO317699 B1 NO 317699B1
- Authority
- NO
- Norway
- Prior art keywords
- proteins
- concentrate
- solution
- protein
- thrombin
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 45
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 45
- 239000012141 concentrate Substances 0.000 title claims abstract description 33
- 108010049003 Fibrinogen Proteins 0.000 title claims abstract description 19
- 102000008946 Fibrinogen Human genes 0.000 title claims abstract description 19
- 229940012952 fibrinogen Drugs 0.000 title claims abstract description 19
- 108010071289 Factor XIII Proteins 0.000 title claims abstract description 18
- 229940012444 factor xiii Drugs 0.000 title claims abstract description 14
- 108090000190 Thrombin Proteins 0.000 title claims abstract description 13
- 229960004072 thrombin Drugs 0.000 title claims abstract description 13
- 108010067306 Fibronectins Proteins 0.000 title claims abstract description 8
- 102000016359 Fibronectins Human genes 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title description 12
- 238000000034 method Methods 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 11
- 241001465754 Metazoa Species 0.000 claims abstract description 7
- 238000005185 salting out Methods 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 25
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 20
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- 239000001509 sodium citrate Substances 0.000 claims description 4
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- 108010010803 Gelatin Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/021,302 US5395923A (en) | 1993-02-23 | 1993-02-23 | Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out" |
| PCT/CA1994/000105 WO1995023167A1 (en) | 1993-02-23 | 1994-02-28 | Process for the obtention of a biological adhesive comprising fibrinogen, factor xiii and fibronectin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO963602D0 NO963602D0 (no) | 1996-08-28 |
| NO963602L NO963602L (no) | 1996-10-17 |
| NO317699B1 true NO317699B1 (no) | 2004-12-06 |
Family
ID=25683079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19963602A NO317699B1 (no) | 1993-02-23 | 1996-08-28 | Fremgangsmate for fremstilling av et proteinkonsentrat som er koagulerbar med trombin, og som inneholder for det meste fibrinogen, endogen faktor XIII og fibronektin. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5395923A (es) |
| EP (1) | EP0748337B1 (es) |
| JP (1) | JP3492694B2 (es) |
| AT (1) | ATE181738T1 (es) |
| AU (1) | AU678439B2 (es) |
| CA (1) | CA2113660C (es) |
| DE (1) | DE69419324T2 (es) |
| DK (1) | DK0748337T3 (es) |
| ES (1) | ES2135564T3 (es) |
| NO (1) | NO317699B1 (es) |
| RU (1) | RU2130946C1 (es) |
| WO (1) | WO1995023167A1 (es) |
Families Citing this family (73)
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| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
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| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
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| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
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| RU2561676C1 (ru) * | 2014-04-07 | 2015-08-27 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Амурская Государственная Медицинская Академия" Министерства Здравоохранения Российской Федерации | Способ получения клеящей массы |
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| US2826533A (en) * | 1954-03-15 | 1958-03-11 | Cutter Lab | Stable fibrinogen solutions and method for producing same |
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| AT390001B (de) * | 1984-09-28 | 1990-03-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern |
| DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
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| US5290918A (en) * | 1993-02-23 | 1994-03-01 | Haemacure Biotech Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation |
-
1993
- 1993-02-23 US US08/021,302 patent/US5395923A/en not_active Expired - Lifetime
-
1994
- 1994-01-18 CA CA002113660A patent/CA2113660C/en not_active Expired - Fee Related
- 1994-02-28 AU AU61515/94A patent/AU678439B2/en not_active Ceased
- 1994-02-28 JP JP52203595A patent/JP3492694B2/ja not_active Expired - Fee Related
- 1994-02-28 DE DE69419324T patent/DE69419324T2/de not_active Expired - Lifetime
- 1994-02-28 DK DK94908221T patent/DK0748337T3/da active
- 1994-02-28 ES ES94908221T patent/ES2135564T3/es not_active Expired - Lifetime
- 1994-02-28 WO PCT/CA1994/000105 patent/WO1995023167A1/en active IP Right Grant
- 1994-02-28 EP EP94908221A patent/EP0748337B1/en not_active Expired - Lifetime
- 1994-02-28 RU RU96119971A patent/RU2130946C1/ru active
- 1994-02-28 AT AT94908221T patent/ATE181738T1/de not_active IP Right Cessation
-
1996
- 1996-08-28 NO NO19963602A patent/NO317699B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2113660A1 (en) | 1994-08-24 |
| NO963602L (no) | 1996-10-17 |
| EP0748337B1 (en) | 1999-06-30 |
| ATE181738T1 (de) | 1999-07-15 |
| DK0748337T3 (da) | 2000-01-17 |
| US5395923A (en) | 1995-03-07 |
| WO1995023167A1 (en) | 1995-08-31 |
| AU678439B2 (en) | 1997-05-29 |
| EP0748337A1 (en) | 1996-12-18 |
| DE69419324D1 (de) | 1999-08-05 |
| RU2130946C1 (ru) | 1999-05-27 |
| CA2113660C (en) | 2000-05-16 |
| DE69419324T2 (de) | 2000-03-02 |
| NO963602D0 (no) | 1996-08-28 |
| ES2135564T3 (es) | 1999-11-01 |
| JP3492694B2 (ja) | 2004-02-03 |
| JPH09509183A (ja) | 1997-09-16 |
| AU6151594A (en) | 1995-09-11 |
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