PT85226A - Process for the preparation of novel trombolytic proteins - Google Patents

Process for the preparation of novel trombolytic proteins

Info

Publication number
PT85226A
PT85226A PT8522687A PT8522687A PT85226A PT 85226 A PT85226 A PT 85226A PT 8522687 A PT8522687 A PT 8522687A PT 8522687 A PT8522687 A PT 8522687A PT 85226 A PT85226 A PT 85226A
Authority
PT
Portugal
Prior art keywords
trombolytic
proteins
novel
preparation
consensus
Prior art date
Application number
PT8522687A
Other languages
Portuguese (pt)
Other versions
PT85226B (en
Inventor
Glenn R Larsen
Tim J Ahern
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/882,051 external-priority patent/US5002887A/en
Priority claimed from PCT/US1987/000257 external-priority patent/WO1987004722A1/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of PT85226A publication Critical patent/PT85226A/en
Publication of PT85226B publication Critical patent/PT85226B/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A thrombolytic protein (I) having tissue plasminogen activator-type activity is characterised by a peptide sequence the same as that of human t-PA in which (a) Arg-275 is deleted or is replaced by a different amino acid and (b) at least one of the consensus N-linked glycosylation sites is modified to other than a consensus N-linked glycosylation site. Also claimed is a thrombolytic protein having tPA-type activity characterised by a peptide sequence the same as that of human t-PA,in which one or more amino acids in the region Gly-(-3) to Thr-91 are deleted or replaced with different.
PT8522687A 1986-07-03 1987-07-01 PROCESS FOR THE PREPARATION OF NEW THROMBOLITIC PROTEINS PT85226B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/882,051 US5002887A (en) 1986-01-31 1986-07-03 Truncated thrombolytic proteins
PCT/US1987/000257 WO1987004722A1 (en) 1986-01-31 1987-01-30 Novel thrombolytic proteins

Publications (2)

Publication Number Publication Date
PT85226A true PT85226A (en) 1987-08-01
PT85226B PT85226B (en) 1990-03-30

Family

ID=26775504

Family Applications (1)

Application Number Title Priority Date Filing Date
PT8522687A PT85226B (en) 1986-07-03 1987-07-01 PROCESS FOR THE PREPARATION OF NEW THROMBOLITIC PROTEINS

Country Status (3)

Country Link
ES (1) ES2004438A6 (en)
GR (1) GR871052B (en)
PT (1) PT85226B (en)

Also Published As

Publication number Publication date
PT85226B (en) 1990-03-30
GR871052B (en) 1987-11-09
ES2004438A6 (en) 1989-01-01

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Effective date: 19920331