ES2133772T3 - Inmunoensayo para la homocisteina. - Google Patents
Inmunoensayo para la homocisteina.Info
- Publication number
- ES2133772T3 ES2133772T3 ES95920371T ES95920371T ES2133772T3 ES 2133772 T3 ES2133772 T3 ES 2133772T3 ES 95920371 T ES95920371 T ES 95920371T ES 95920371 T ES95920371 T ES 95920371T ES 2133772 T3 ES2133772 T3 ES 2133772T3
- Authority
- ES
- Spain
- Prior art keywords
- analyte
- homocysteine
- immunologically
- antibodies
- modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION ESTA RELACIONADA CON METODOS PARA DETECTAR UN COMPUESTO EN PRESENCIA DE UN HOMOLOGO QUE ESTA INMUNOLOGICAMENTE RELACIONADO CON EL ANALITO. LA INVENCION PARTICULARMENTE ADECUADA PARA LA DETECCION DE HOMOCISTEINA EN PRESENCIA DE CISTEINA. LOS METODOS DE ESTA INVENCION LLEVAN CONSIGO LA MODIFICACION DE AMBOS EL ANALITO Y EL HOMOLOGO PARA INCREMENTAR SU INMUNOGENICIDAD Y FACILITAR EL RECONOCIMIENTO DE ANTICUERPOS. DE MANERA MAS IMPORTANTE, SE HACE ESTA MODIFICACION PARA HACER QUE ESTOS COMPUESTOS SEAN DISTINTOS INMUNOLOGICAMENTE. DESPUES, SE PREPARAN LOS ANTICUERPOS DE LOS COMPUESTOS DISTINTOS INMUNOLOGICAMENTE. UN PROTOCOLO DE ENSAYO CONSISTE EN LA MODIFICACION QUIMICA DEL ANALITO Y EL HOMOLOGO Y, DESPUES, LA DETECCION INMUNOQUIMICA DEL ANALITO MODIFICADO POR MEDIO DE LOS ANTICUERPOS MENCIONADOS ANTERIORMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/234,456 US5478729A (en) | 1994-04-28 | 1994-04-28 | Immunoassay for homocysteine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2133772T3 true ES2133772T3 (es) | 1999-09-16 |
Family
ID=22881471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95920371T Expired - Lifetime ES2133772T3 (es) | 1994-04-28 | 1995-04-27 | Inmunoensayo para la homocisteina. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5478729A (es) |
EP (1) | EP0757794B1 (es) |
JP (1) | JP3422795B2 (es) |
AU (1) | AU2584495A (es) |
CA (1) | CA2188752C (es) |
DE (1) | DE69504191T2 (es) |
ES (1) | ES2133772T3 (es) |
WO (1) | WO1995030151A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063581A (en) * | 1992-01-22 | 2000-05-16 | Axis-Shield Asa | Immunoassay for homocysteine |
US5393669A (en) * | 1993-02-05 | 1995-02-28 | Martek Biosciences Corp. | Compositions and methods for protein structural determinations |
AU7031598A (en) * | 1997-03-06 | 1998-09-22 | Evotec Biosystems Gmbh | Method for specifically marking a protein |
DE19713088C1 (de) | 1997-03-27 | 1998-11-26 | Reiner Dr Probst | Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung |
US6020206A (en) * | 1997-06-23 | 2000-02-01 | Nexstar Pharmaceuticals, Inc. | Homocysteine assay |
US5985540A (en) * | 1997-07-24 | 1999-11-16 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
US6066467A (en) * | 1997-07-24 | 2000-05-23 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
US6140102A (en) * | 1997-07-24 | 2000-10-31 | Anticancer, Inc. | High specificity homocysteinases and genes therefor |
US6468762B1 (en) | 1997-07-24 | 2002-10-22 | Anticancer, Inc. | High specificity homocysteinases |
US6589751B2 (en) * | 1997-11-04 | 2003-07-08 | Mcw Research Foundation | Immonological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine |
US5885767A (en) * | 1998-05-22 | 1999-03-23 | Biocatalytics, Inc. | Methods and compositions for quantitating L-homocysteine and/or l-methionine in a solution |
WO2000000821A1 (en) | 1998-06-29 | 2000-01-06 | Ullman Edwin F | Assay for homocysteine |
US6174696B1 (en) | 1999-11-12 | 2001-01-16 | Genzyme Corporation | Method for the determination of homocysteine |
CA2361077C (en) | 1999-02-01 | 2010-10-19 | Anticancer, Inc. | Homogeneous enzymatic assay for vitamin b6 and improvements in h2s detection |
US7105310B1 (en) * | 2000-07-19 | 2006-09-12 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
WO2001006260A1 (en) * | 1999-07-19 | 2001-01-25 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
US6783947B1 (en) * | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
ATE377655T1 (de) | 2000-06-30 | 2007-11-15 | Alfresa Pharma Corp | Verfahren zum messen von gesamt-homocystein |
CA2422856C (en) * | 2000-09-25 | 2012-02-07 | Abbott Laboratories | Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation |
AU2002318396A1 (en) * | 2001-06-21 | 2003-01-08 | The Cleveland Clinic Foundation | Homocysteinylated transthyretin |
US20050019937A1 (en) * | 2002-11-29 | 2005-01-27 | Industrial Technology Research Institute | Assay and kit for homocysteine |
JP2006149203A (ja) * | 2003-02-19 | 2006-06-15 | Alfresa Pharma Corp | ホモシステインの測定方法 |
US9201075B2 (en) | 2004-04-30 | 2015-12-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Colorimetric and fluorometric determination of homocysteine and cysteine |
US20070259376A1 (en) * | 2005-12-22 | 2007-11-08 | Toru Yoshimura | Homocysteine immunoassay |
JP2007170992A (ja) * | 2005-12-22 | 2007-07-05 | Abbott Japan Co Ltd | ホモシステインの免疫学的測定方法 |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
US20160289728A1 (en) * | 2013-11-21 | 2016-10-06 | The University Of Tokyo | Method for detecting fluorescence or absorbance, method for suppressing background, method for measuring adp, method for measuring activity of adp-synthesizing enzyme, and method for measuring activity of glucosyltransferase |
JP6811581B2 (ja) * | 2016-10-25 | 2021-01-13 | 福井県 | 人血検査方法及び人血検査用キット |
CN114181909B (zh) * | 2021-11-25 | 2023-06-06 | 深圳市圳康科技有限公司 | 一种杂交瘤细胞株及其单克隆抗体与试剂盒 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
US5374560A (en) * | 1989-04-03 | 1994-12-20 | The University Of Colorado, Inc. | Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid |
US4868132A (en) * | 1987-02-03 | 1989-09-19 | Abbott Laboratories | Fluorescence polarization immunoassay for amphetamine/methamphetamine |
US4952336A (en) * | 1987-02-03 | 1990-08-28 | Abbott Laboratories | Fluorescence polymerization immunoassay for amphetamine/methamphetamine |
CA1335880C (en) * | 1988-07-14 | 1995-06-13 | Thomas P. O'connor | Detection of an antibody and antigen in an immunoassay |
US4978632A (en) * | 1988-12-15 | 1990-12-18 | Kallestad Diagnostics, Inc. | Method of pre-treating samples in peroxidase-catalyzed enzyme assays |
GB8924112D0 (en) * | 1989-10-26 | 1989-12-13 | Univ Southampton | Assay pretreatment |
WO1993012424A1 (en) * | 1991-12-13 | 1993-06-24 | Abbott Laboratories | Determination of tricyclic antidepressant drugs in the presence of interfering substances |
WO1993015220A1 (en) * | 1992-01-22 | 1993-08-05 | Axis Biochemicals As | Homocysteine assay |
US5484706A (en) * | 1993-05-19 | 1996-01-16 | Pasteur Sanofi Diagnostics | Immunoassay for analytes in samples using alkylating agents |
-
1994
- 1994-04-28 US US08/234,456 patent/US5478729A/en not_active Expired - Lifetime
-
1995
- 1995-04-27 CA CA002188752A patent/CA2188752C/en not_active Expired - Fee Related
- 1995-04-27 JP JP52837295A patent/JP3422795B2/ja not_active Expired - Fee Related
- 1995-04-27 ES ES95920371T patent/ES2133772T3/es not_active Expired - Lifetime
- 1995-04-27 EP EP95920371A patent/EP0757794B1/en not_active Expired - Lifetime
- 1995-04-27 WO PCT/US1995/005201 patent/WO1995030151A1/en active IP Right Grant
- 1995-04-27 DE DE69504191T patent/DE69504191T2/de not_active Expired - Fee Related
- 1995-04-27 AU AU25844/95A patent/AU2584495A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69504191D1 (de) | 1998-09-24 |
JP3422795B2 (ja) | 2003-06-30 |
AU2584495A (en) | 1995-11-29 |
EP0757794A1 (en) | 1997-02-12 |
US5478729A (en) | 1995-12-26 |
CA2188752C (en) | 2002-08-06 |
DE69504191T2 (de) | 1999-02-11 |
CA2188752A1 (en) | 1995-11-09 |
WO1995030151A1 (en) | 1995-11-09 |
EP0757794B1 (en) | 1998-08-19 |
JPH09512634A (ja) | 1997-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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