ES2133593T3 - Nuevos medicamentos que contienen compuestos de 3-fenilsulfonil-3,7-diazabiciclo(3,3,1)nonano. - Google Patents

Nuevos medicamentos que contienen compuestos de 3-fenilsulfonil-3,7-diazabiciclo(3,3,1)nonano.

Info

Publication number
ES2133593T3
ES2133593T3 ES95100954T ES95100954T ES2133593T3 ES 2133593 T3 ES2133593 T3 ES 2133593T3 ES 95100954 T ES95100954 T ES 95100954T ES 95100954 T ES95100954 T ES 95100954T ES 2133593 T3 ES2133593 T3 ES 2133593T3
Authority
ES
Spain
Prior art keywords
rent
group
carbon atoms
nonano
fenile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95100954T
Other languages
English (en)
Inventor
Uwe Dr Schon
Arman Dr Farjam
Reinhard Dr Bruckner
Dieter Dr Ziegler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Application granted granted Critical
Publication of ES2133593T3 publication Critical patent/ES2133593T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE LA UTILIZACION DE COMPUESTOS 3 - FENILSULFONIL 3,7 - DIAZABICICLO[3,3,1]NONANO 3,7,9,9 - TETRASUSTITUIDO PARA LA ELABORACION DE MEDICAMENTOS DE ACTIVIDAD ANTIARRITMICA Y NUEVOS COMPUESTOS 3,7,9,9 - TETRASUSTITUIDOS ACTIVOS ANTIERRITMICOS DE LA FORMULA GENERAL LA DONDE R1 SIGNIFICA UN GRUPO ALQUIL CON 1 - 6 ATOMOS DE CARBONO O UN GRUPO CICLO ALQUILALQUIL CON 4 - 7 ATOMOS DE CARBONO, R2 SIGNIFICA ALQUIL INFERIOR, R3 SIGNIFICA ALQUIL INFERIOR O R2 Y R3 CONJUNTAMENTE FORMAN UNA CADENA ALQUILENO CON 3 - 6 ATOMOS DE CARBONO, R4 ES CIANO, UN GRUPO R6 - O - CO, DONDE R6 SIGNIFICA ALQUIL, UN GRUPO R7 - SO2 - NH, DONDE R7 SIGNIFICA ALQUIL INFERIOR, O UN GRUPO R8 - CO NH, DONDE R8 ES ALQUIL INFERIOR O UN GRUPO FENIL, QUE ES SUSTITUIDO EVENTUALMENTE POR HALOGENO, CIANO, NITRO O UN RESTO R9 SO2, DONDE R9 ES ALQUIL INFERIOR, O UN RESTO IMIDAZOIL DISPUESTO EN LA POSICION 4 DEL ANILLO FENIL, Y R5 SIGNIFICA HIDROGENO O HALOGENO, Y SUS SALES DE ADICION ACIDA TOLERABLES FISIOLOGICAMENTE ASI COMO PROCESO Y PRODUCTOS INTERMEDIOS PARA SU ELABORACION.
ES95100954T 1994-02-01 1995-01-25 Nuevos medicamentos que contienen compuestos de 3-fenilsulfonil-3,7-diazabiciclo(3,3,1)nonano. Expired - Lifetime ES2133593T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4402931A DE4402931A1 (de) 1994-02-01 1994-02-01 Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES2133593T3 true ES2133593T3 (es) 1999-09-16

Family

ID=6509146

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95100954T Expired - Lifetime ES2133593T3 (es) 1994-02-01 1995-01-25 Nuevos medicamentos que contienen compuestos de 3-fenilsulfonil-3,7-diazabiciclo(3,3,1)nonano.

Country Status (21)

Country Link
US (2) US5576327A (es)
EP (1) EP0665228B1 (es)
JP (2) JP3853389B2 (es)
KR (1) KR100352899B1 (es)
CN (1) CN1111631A (es)
AT (1) ATE182149T1 (es)
AU (1) AU1156495A (es)
CA (1) CA2141366A1 (es)
CZ (1) CZ25395A3 (es)
DE (2) DE4402931A1 (es)
ES (1) ES2133593T3 (es)
FI (1) FI950422A7 (es)
HU (1) HUT70174A (es)
IL (1) IL112364A (es)
NO (1) NO950360L (es)
NZ (1) NZ270371A (es)
PL (1) PL180075B1 (es)
RU (1) RU95101437A (es)
SK (1) SK11795A3 (es)
UA (1) UA41329C2 (es)
ZA (1) ZA95697B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004113A1 (en) * 1999-06-16 2005-01-06 Astrazeneca Ab New bispidine compounds useful in the treatment of cardiac arrhythmias
SE9902270D0 (sv) 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
US20040229900A1 (en) * 1999-06-16 2004-11-18 Astrazeneca Ab Bispidine compounds useful in the treatment of cardiac arrythmias
SE9904765D0 (sv) 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
US6808924B1 (en) 2000-07-11 2004-10-26 Claudia Lanari Mouse mammary tumor lines expressing estrogen and progesterone receptors
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
SE0100326D0 (sv) 2001-02-02 2001-02-02 Astrazeneca Ab New compounds
DE10131217A1 (de) 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
TW200418468A (en) * 2002-11-18 2004-10-01 Solvay Pharm Gmbh Liquid pharmaceutical formulations containing 3,7-diazabicyclo[3,3,1]nonane compounds and method of treatments relating to anti-arrhytmic events

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722134A1 (de) * 1987-07-04 1989-01-19 Kali Chemie Pharma Gmbh 3-sulfonyl-3,7-diazabicyclo(3,3,1)nonan- verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5153214A (en) * 1989-06-28 1992-10-06 Ciba-Geigy Corporation Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof

Also Published As

Publication number Publication date
US5635511A (en) 1997-06-03
CA2141366A1 (en) 1995-08-02
UA41329C2 (uk) 2001-09-17
ZA95697B (en) 1996-02-07
DE4402931A1 (de) 1995-08-03
DE59506374D1 (de) 1999-08-19
HU9500262D0 (en) 1995-03-28
NO950360D0 (no) 1995-01-31
KR950031075A (ko) 1995-12-18
CN1111631A (zh) 1995-11-15
FI950422L (fi) 1995-08-02
MX9500679A (es) 1998-03-31
US5576327A (en) 1996-11-19
SK11795A3 (en) 1995-08-09
PL307000A1 (en) 1995-08-07
EP0665228A1 (de) 1995-08-02
EP0665228B1 (de) 1999-07-14
HUT70174A (en) 1995-09-28
NZ270371A (en) 1997-02-24
JPH07267954A (ja) 1995-10-17
RU95101437A (ru) 1996-10-27
IL112364A0 (en) 1995-03-30
JP3853389B2 (ja) 2006-12-06
CZ25395A3 (en) 1995-10-18
FI950422A7 (fi) 1995-08-02
KR100352899B1 (ko) 2003-02-05
ATE182149T1 (de) 1999-07-15
IL112364A (en) 1998-01-04
AU1156495A (en) 1995-08-10
NO950360L (no) 1995-08-02
JP2005232179A (ja) 2005-09-02
PL180075B1 (pl) 2000-12-29
FI950422A0 (fi) 1995-01-31

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