ES2117132T3 - Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral. - Google Patents
Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral.Info
- Publication number
- ES2117132T3 ES2117132T3 ES93911928T ES93911928T ES2117132T3 ES 2117132 T3 ES2117132 T3 ES 2117132T3 ES 93911928 T ES93911928 T ES 93911928T ES 93911928 T ES93911928 T ES 93911928T ES 2117132 T3 ES2117132 T3 ES 2117132T3
- Authority
- ES
- Spain
- Prior art keywords
- chelelers
- desferrioxamine
- salts
- effective iron
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical class CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 title 1
- 229910052742 iron Inorganic materials 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UNA SAL DE LA FORMULA (I) EN DONDE X REPRESENTA UN GRUPO DE LA FORMULA (II), Y REPRESENTA UN GRUPO DE LA FORMULA (III) Y R REPRESENTA EL RESIDUO DE UN ACIDO SULFONICO ALIFATICO O CICLOALIFATICO QUE TIENE AL MENOS TRES ATOMOS DE CARBONO DESPUES DE LA ELIMINACION DEL MISMO DE UN GRUPO - SO3H.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929211779A GB9211779D0 (en) | 1992-06-03 | 1992-06-03 | Amine salts |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2117132T3 true ES2117132T3 (es) | 1998-08-01 |
Family
ID=10716488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93911928T Expired - Lifetime ES2117132T3 (es) | 1992-06-03 | 1993-05-06 | Sales de desferrioxamina-b y su uso como queladores de hierro eficaces por via oral. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5739167A (es) |
EP (1) | EP0643690B1 (es) |
JP (1) | JPH07507288A (es) |
KR (1) | KR950701907A (es) |
AT (1) | ATE166342T1 (es) |
AU (1) | AU672607B2 (es) |
CA (1) | CA2135394A1 (es) |
DE (1) | DE69318711T2 (es) |
DK (1) | DK0643690T3 (es) |
ES (1) | ES2117132T3 (es) |
FI (1) | FI945654A0 (es) |
GB (1) | GB9211779D0 (es) |
HK (1) | HK1009330A1 (es) |
NO (1) | NO302749B1 (es) |
NZ (1) | NZ252738A (es) |
TW (1) | TW230203B (es) |
WO (1) | WO1993024451A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR009655A1 (es) * | 1996-12-10 | 2000-04-26 | Novartis Ag | Una composicion parenteralmente inyectable, un metodo para su preparacion, metodos para el tratamiento de enfermedades, una modificacion decristal de 1-decansulfonato de desferrioxamina, su uso, un proceso para la produccion de dicha modificacion de cristal y una preparacion farmaceutica que |
US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
GB9727224D0 (en) * | 1997-12-23 | 1998-02-25 | Nycomed Imaging As | Method |
US6323218B1 (en) | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
US6958161B2 (en) * | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
US8236783B2 (en) * | 2006-08-15 | 2012-08-07 | Duke University | ROS-sensitive iron chelators and methods of using the same |
US9259670B2 (en) | 2008-04-16 | 2016-02-16 | The University Of Kentucky Research Foundation | Flow-through filter to remove aluminum from medical solutions |
US9139456B2 (en) | 2008-04-16 | 2015-09-22 | The Curators Of The University Of Missouri | Chelating compounds and immobilized tethered chelators |
US7932326B2 (en) * | 2008-04-16 | 2011-04-26 | The University Of Kentucky Research Foundation | Chelating compounds and immobilized tethered chelators |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
FR1898M (fr) * | 1961-04-07 | 1963-07-08 | Ciba Geigy | Nouvelle substance utilisable en thérapeutique. |
US3679660A (en) * | 1969-06-09 | 1972-07-25 | Agatha C Magnus | Glucosamine-alkylsulfonate and process |
US3652411A (en) * | 1969-12-04 | 1972-03-28 | Mobil Oil Corp | Polyglycol base lubricant |
US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
US4684482A (en) * | 1984-01-26 | 1987-08-04 | Oral-D (L.P.) | Orally effective ion chelators |
IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
MX12394A (es) * | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | Procedimiento par la obtencion de carbamatos de polietilenglicol. |
AU1996192A (en) * | 1991-05-13 | 1992-12-30 | Oral-D | Substituted orally effective ion chelators related to deferoxamine |
-
1992
- 1992-06-03 GB GB929211779A patent/GB9211779D0/en active Pending
-
1993
- 1993-04-22 TW TW082103080A patent/TW230203B/zh active
- 1993-05-06 JP JP6500277A patent/JPH07507288A/ja active Pending
- 1993-05-06 WO PCT/GB1993/000940 patent/WO1993024451A1/en active IP Right Grant
- 1993-05-06 NZ NZ252738A patent/NZ252738A/en unknown
- 1993-05-06 AU AU42700/93A patent/AU672607B2/en not_active Ceased
- 1993-05-06 DE DE69318711T patent/DE69318711T2/de not_active Expired - Lifetime
- 1993-05-06 AT AT93911928T patent/ATE166342T1/de not_active IP Right Cessation
- 1993-05-06 KR KR1019940704389A patent/KR950701907A/ko not_active Application Discontinuation
- 1993-05-06 US US08/343,599 patent/US5739167A/en not_active Expired - Lifetime
- 1993-05-06 EP EP93911928A patent/EP0643690B1/en not_active Expired - Lifetime
- 1993-05-06 DK DK93911928T patent/DK0643690T3/da active
- 1993-05-06 CA CA002135394A patent/CA2135394A1/en not_active Abandoned
- 1993-05-06 ES ES93911928T patent/ES2117132T3/es not_active Expired - Lifetime
-
1994
- 1994-11-30 FI FI945654A patent/FI945654A0/fi unknown
- 1994-12-01 NO NO944617A patent/NO302749B1/no not_active IP Right Cessation
-
1996
- 1996-03-11 US US08/613,562 patent/US5663201A/en not_active Expired - Lifetime
-
1998
- 1998-08-18 HK HK98109975A patent/HK1009330A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1993024451A1 (en) | 1993-12-09 |
NO944617D0 (no) | 1994-12-01 |
KR950701907A (ko) | 1995-05-17 |
GB9211779D0 (en) | 1992-07-15 |
NO302749B1 (no) | 1998-04-20 |
AU672607B2 (en) | 1996-10-10 |
CA2135394A1 (en) | 1993-12-09 |
FI945654A (fi) | 1994-11-30 |
HK1009330A1 (en) | 1999-05-28 |
NZ252738A (en) | 1996-08-27 |
EP0643690B1 (en) | 1998-05-20 |
EP0643690A1 (en) | 1995-03-22 |
TW230203B (es) | 1994-09-11 |
DK0643690T3 (da) | 1999-01-25 |
AU4270093A (en) | 1993-12-30 |
FI945654A0 (fi) | 1994-11-30 |
JPH07507288A (ja) | 1995-08-10 |
DE69318711T2 (de) | 1998-11-19 |
NO944617L (no) | 1995-01-05 |
DE69318711D1 (de) | 1998-06-25 |
ATE166342T1 (de) | 1998-06-15 |
US5739167A (en) | 1998-04-14 |
US5663201A (en) | 1997-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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