HK1009330A1 - Desferrioxamine-b salts and their use as orally effective iron chelators - Google Patents
Desferrioxamine-b salts and their use as orally effective iron chelatorsInfo
- Publication number
- HK1009330A1 HK1009330A1 HK98109975A HK98109975A HK1009330A1 HK 1009330 A1 HK1009330 A1 HK 1009330A1 HK 98109975 A HK98109975 A HK 98109975A HK 98109975 A HK98109975 A HK 98109975A HK 1009330 A1 HK1009330 A1 HK 1009330A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pct
- desferrioxamine
- salts
- iron chelators
- orally effective
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title 2
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical class CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 title 1
- 239000002738 chelating agent Substances 0.000 title 1
- 229910052742 iron Inorganic materials 0.000 title 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929211779A GB9211779D0 (en) | 1992-06-03 | 1992-06-03 | Amine salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1009330A1 true HK1009330A1 (en) | 1999-05-28 |
Family
ID=10716488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98109975A HK1009330A1 (en) | 1992-06-03 | 1998-08-18 | Desferrioxamine-b salts and their use as orally effective iron chelators |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5739167A (xx) |
| EP (1) | EP0643690B1 (xx) |
| JP (1) | JPH07507288A (xx) |
| KR (1) | KR950701907A (xx) |
| AT (1) | ATE166342T1 (xx) |
| AU (1) | AU672607B2 (xx) |
| CA (1) | CA2135394A1 (xx) |
| DE (1) | DE69318711T2 (xx) |
| DK (1) | DK0643690T3 (xx) |
| ES (1) | ES2117132T3 (xx) |
| FI (1) | FI945654A (xx) |
| GB (1) | GB9211779D0 (xx) |
| HK (1) | HK1009330A1 (xx) |
| NO (1) | NO302749B1 (xx) |
| NZ (1) | NZ252738A (xx) |
| TW (1) | TW230203B (xx) |
| WO (1) | WO1993024451A1 (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE27799A1 (es) * | 1996-12-10 | 1999-03-18 | Novartis Ag | Formulaciones y formas polimorficas de desferrioxamina y su preparacion |
| US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
| GB9727224D0 (en) * | 1997-12-23 | 1998-02-25 | Nycomed Imaging As | Method |
| US6323218B1 (en) | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
| US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
| GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| US6958161B2 (en) * | 2002-04-12 | 2005-10-25 | F H Faulding & Co Limited | Modified release coated drug preparation |
| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| US8236783B2 (en) * | 2006-08-15 | 2012-08-07 | Duke University | ROS-sensitive iron chelators and methods of using the same |
| US9139456B2 (en) | 2008-04-16 | 2015-09-22 | The Curators Of The University Of Missouri | Chelating compounds and immobilized tethered chelators |
| US9259670B2 (en) | 2008-04-16 | 2016-02-16 | The University Of Kentucky Research Foundation | Flow-through filter to remove aluminum from medical solutions |
| US7932326B2 (en) * | 2008-04-16 | 2011-04-26 | The University Of Kentucky Research Foundation | Chelating compounds and immobilized tethered chelators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
| FR1898M (fr) * | 1961-04-07 | 1963-07-08 | Ciba Geigy | Nouvelle substance utilisable en thérapeutique. |
| US3679660A (en) * | 1969-06-09 | 1972-07-25 | Agatha C Magnus | Glucosamine-alkylsulfonate and process |
| US3652411A (en) * | 1969-12-04 | 1972-03-28 | Mobil Oil Corp | Polyglycol base lubricant |
| US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
| US4684482A (en) * | 1984-01-26 | 1987-08-04 | Oral-D (L.P.) | Orally effective ion chelators |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| MX12394A (es) * | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | Procedimiento par la obtencion de carbamatos de polietilenglicol. |
| WO1992020227A1 (en) * | 1991-05-13 | 1992-11-26 | Oral-D | Substituted orally effective ion chelators related to deferoxamine |
-
1992
- 1992-06-03 GB GB929211779A patent/GB9211779D0/en active Pending
-
1993
- 1993-04-22 TW TW082103080A patent/TW230203B/zh active
- 1993-05-06 KR KR1019940704389A patent/KR950701907A/ko not_active Application Discontinuation
- 1993-05-06 NZ NZ252738A patent/NZ252738A/en unknown
- 1993-05-06 AT AT93911928T patent/ATE166342T1/de not_active IP Right Cessation
- 1993-05-06 JP JP6500277A patent/JPH07507288A/ja active Pending
- 1993-05-06 CA CA002135394A patent/CA2135394A1/en not_active Abandoned
- 1993-05-06 AU AU42700/93A patent/AU672607B2/en not_active Ceased
- 1993-05-06 US US08/343,599 patent/US5739167A/en not_active Expired - Lifetime
- 1993-05-06 EP EP93911928A patent/EP0643690B1/en not_active Expired - Lifetime
- 1993-05-06 DK DK93911928T patent/DK0643690T3/da active
- 1993-05-06 WO PCT/GB1993/000940 patent/WO1993024451A1/en active IP Right Grant
- 1993-05-06 DE DE69318711T patent/DE69318711T2/de not_active Expired - Lifetime
- 1993-05-06 ES ES93911928T patent/ES2117132T3/es not_active Expired - Lifetime
-
1994
- 1994-11-30 FI FI945654A patent/FI945654A/fi unknown
- 1994-12-01 NO NO944617A patent/NO302749B1/no not_active IP Right Cessation
-
1996
- 1996-03-11 US US08/613,562 patent/US5663201A/en not_active Expired - Lifetime
-
1998
- 1998-08-18 HK HK98109975A patent/HK1009330A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO944617D0 (no) | 1994-12-01 |
| AU4270093A (en) | 1993-12-30 |
| DE69318711D1 (de) | 1998-06-25 |
| JPH07507288A (ja) | 1995-08-10 |
| ATE166342T1 (de) | 1998-06-15 |
| TW230203B (xx) | 1994-09-11 |
| US5663201A (en) | 1997-09-02 |
| ES2117132T3 (es) | 1998-08-01 |
| CA2135394A1 (en) | 1993-12-09 |
| EP0643690A1 (en) | 1995-03-22 |
| US5739167A (en) | 1998-04-14 |
| AU672607B2 (en) | 1996-10-10 |
| KR950701907A (ko) | 1995-05-17 |
| DE69318711T2 (de) | 1998-11-19 |
| FI945654A0 (fi) | 1994-11-30 |
| NZ252738A (en) | 1996-08-27 |
| FI945654A (fi) | 1994-11-30 |
| EP0643690B1 (en) | 1998-05-20 |
| NO302749B1 (no) | 1998-04-20 |
| GB9211779D0 (en) | 1992-07-15 |
| WO1993024451A1 (en) | 1993-12-09 |
| DK0643690T3 (da) | 1999-01-25 |
| NO944617L (no) | 1995-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |