NL7701227A - (3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents - Google Patents

(3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents

Info

Publication number
NL7701227A
NL7701227A NL7701227A NL7701227A NL7701227A NL 7701227 A NL7701227 A NL 7701227A NL 7701227 A NL7701227 A NL 7701227A NL 7701227 A NL7701227 A NL 7701227A NL 7701227 A NL7701227 A NL 7701227A
Authority
NL
Netherlands
Prior art keywords
pyridylimino
isoquinolines
thiazolo
halo
orally
Prior art date
Application number
NL7701227A
Other languages
Dutch (nl)
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Priority to NL7701227A priority Critical patent/NL7701227A/en
Publication of NL7701227A publication Critical patent/NL7701227A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Thiazolo-isoquinolines of formula (I), in (R) or (S) forms or their mixts. and their acid addition salts are new. In the formula, X1=H, halo, CH3O or CN. X2=H, halo or CH3O; or X1 + X2 = methylenedioxy. Y1 and Y2 = H, halo, 1-4C alkyl, alkoxy or alkylthio, OH diacetylamino or NH2. They are prepd. e.g. by acid cyclisation of 2-(pyridylaminothiocarbonyl). 3-hydroxymethyl-tetrahydroisoquinoline. (I) are anti-ulcer agents e.g. they antagonise the histamine-induced gastric acid secretion at 10-50 mg/kg orally and some are effective against experimentally-induced gastric ulcers at 20-100 mg/kg. Toxicity is >=100 mg/kg orally and most show no signs of toxicity at 900 mg/kg orally in mice. A typical cpd. is (5)-3-(2-pyridylimino)-1,5,10,10a-tetrahydrothiazolo 3,4,b isoquinoline.
NL7701227A 1977-02-04 1977-02-04 (3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents NL7701227A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7701227A NL7701227A (en) 1977-02-04 1977-02-04 (3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7701227A NL7701227A (en) 1977-02-04 1977-02-04 (3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents

Publications (1)

Publication Number Publication Date
NL7701227A true NL7701227A (en) 1978-08-08

Family

ID=19827927

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7701227A NL7701227A (en) 1977-02-04 1977-02-04 (3)-Pyridylimino thiazolo-(3,4-b)-tetrahydro-isoquinolines - useful as antiulcer agents

Country Status (1)

Country Link
NL (1) NL7701227A (en)

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Legal Events

Date Code Title Description
BV The patent application has lapsed