ES2133582T3 - Esteroides heterociclicos de c17 delta16-insaturados utiles como inhibidores de esteroide c17-20 liasa. - Google Patents

Esteroides heterociclicos de c17 delta16-insaturados utiles como inhibidores de esteroide c17-20 liasa.

Info

Publication number
ES2133582T3
ES2133582T3 ES94929935T ES94929935T ES2133582T3 ES 2133582 T3 ES2133582 T3 ES 2133582T3 ES 94929935 T ES94929935 T ES 94929935T ES 94929935 T ES94929935 T ES 94929935T ES 2133582 T3 ES2133582 T3 ES 2133582T3
Authority
ES
Spain
Prior art keywords
liasa
steroid
inhibitors
useful
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929935T
Other languages
English (en)
Inventor
Norton P Peet
Joseph P Burkhart
Cynthia P Gates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2133582T3 publication Critical patent/ES2133582T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ESTEROIDES HETEROCICLICOS C{SUB,17} {DL}{SUP,16} NO SATURADOS QUE SON UTILES COMO INHIBIDORES DE LIASA C{SUB,17-20} DE ESTEROIDE.
ES94929935T 1993-10-27 1994-09-29 Esteroides heterociclicos de c17 delta16-insaturados utiles como inhibidores de esteroide c17-20 liasa. Expired - Lifetime ES2133582T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14367993A 1993-10-27 1993-10-27

Publications (1)

Publication Number Publication Date
ES2133582T3 true ES2133582T3 (es) 1999-09-16

Family

ID=22505119

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929935T Expired - Lifetime ES2133582T3 (es) 1993-10-27 1994-09-29 Esteroides heterociclicos de c17 delta16-insaturados utiles como inhibidores de esteroide c17-20 liasa.

Country Status (19)

Country Link
US (3) US5677293A (es)
EP (1) EP0724591B1 (es)
JP (1) JPH09511214A (es)
KR (1) KR960705838A (es)
CN (1) CN1046736C (es)
AT (1) ATE177751T1 (es)
AU (2) AU684844B2 (es)
CA (1) CA2173729C (es)
DE (1) DE69417248T2 (es)
DK (1) DK0724591T3 (es)
ES (1) ES2133582T3 (es)
FI (1) FI961792A7 (es)
GR (1) GR3030263T3 (es)
HU (1) HUT73855A (es)
IL (1) IL111364A0 (es)
NO (1) NO961693L (es)
NZ (1) NZ274694A (es)
WO (1) WO1995011914A1 (es)
ZA (1) ZA948310B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
WO2001005364A1 (en) * 1999-07-15 2001-01-25 The Procter & Gamble Company Nitrogen-containing steroid compounds and their use to regulate hair growth
EP2147679B1 (en) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions for blood-brain barrier transport
US6562457B1 (en) 2001-10-31 2003-05-13 E. I. Du Pont De Nemours And Company Polyether ester elastomer comprising polytrimethylene ether ester soft segment and tetramethylene ester hard segment
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
WO2011088160A2 (en) * 2010-01-15 2011-07-21 Biomarin Pharmaceutical Inc. Novel cyp17 inhibitors
KR101926320B1 (ko) 2010-08-04 2018-12-06 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
CN102746358B (zh) * 2011-04-22 2016-02-10 天津金耀集团有限公司 一种合成孕甾21位溴化物的工艺
CN102898495B (zh) * 2012-11-12 2014-11-26 浙江神洲药业有限公司 醋酸阿比特龙酯的制备方法
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
WO2014158875A1 (en) 2013-03-14 2014-10-02 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
CA2960750A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
HUP1500055A1 (hu) 2015-02-09 2016-08-29 Druggability Technologies Ip Holdco Ltd Abirateron acetát komplexei, eljárás elõállításukra, és az azokat tartalmazó gyógyászati készítmények
WO2018080933A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
CN106866773A (zh) * 2017-02-14 2017-06-20 西北农林科技大学 一组具有抗癌活性吡唑基甾体衍生物的制备方法及应用
CN116621905B (zh) * 2023-06-06 2025-07-15 西北农林科技大学 双烯噻唑类衍生物及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081647A (en) * 1965-04-01 1967-08-31 Shionogi & Co Furan compounds
AT253975B (de) * 1965-06-15 1967-05-10 Carinthia Elektrogeraete Ges M Trockenrasierapparat
US3436390A (en) * 1966-05-24 1969-04-01 American Home Prod 4,4-dihydroxy-2-butenoic acid lactones
US3398138A (en) * 1966-05-24 1968-08-20 American Home Prod Novel cardenolides and derivatives
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
US4523917A (en) * 1983-12-27 1985-06-18 Dana Corporation Variable pitch diameter torque sensing pulley assembly
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
CZ287434B6 (en) * 1992-03-31 2000-11-15 British Tech Group Use of steroids, substituted in position 17, steroids functioning as carcinostatics and pharmaceutical preparation containing thereof
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
NZ274694A (en) 1998-01-26
ZA948310B (en) 1995-06-14
US5977094A (en) 1999-11-02
DE69417248T2 (de) 1999-08-19
GR3030263T3 (en) 1999-08-31
EP0724591A1 (en) 1996-08-07
KR960705838A (ko) 1996-11-08
HUT73855A (en) 1996-09-30
WO1995011914A1 (en) 1995-05-04
CN1133596A (zh) 1996-10-16
US5965548A (en) 1999-10-12
FI961792L (fi) 1996-04-26
NO961693D0 (no) 1996-04-26
FI961792A0 (fi) 1996-04-26
CN1046736C (zh) 1999-11-24
AU3993097A (en) 1998-01-08
AU695341B2 (en) 1998-08-13
AU684844B2 (en) 1998-01-08
AU7922394A (en) 1995-05-22
EP0724591B1 (en) 1999-03-17
FI961792A7 (fi) 1996-04-26
JPH09511214A (ja) 1997-11-11
US5677293A (en) 1997-10-14
IL111364A0 (en) 1994-12-29
CA2173729C (en) 2001-05-15
HU9601113D0 (en) 1996-07-29
CA2173729A1 (en) 1995-05-04
DE69417248D1 (de) 1999-04-22
NO961693L (no) 1996-04-26
ATE177751T1 (de) 1999-04-15
DK0724591T3 (da) 1999-09-27

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