ES2132780T3 - Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos. - Google Patents

Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Info

Publication number
ES2132780T3
ES2132780T3 ES96100985T ES96100985T ES2132780T3 ES 2132780 T3 ES2132780 T3 ES 2132780T3 ES 96100985 T ES96100985 T ES 96100985T ES 96100985 T ES96100985 T ES 96100985T ES 2132780 T3 ES2132780 T3 ES 2132780T3
Authority
ES
Spain
Prior art keywords
divalent
salt
soluble
monovalent
phosfatides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96100985T
Other languages
English (en)
Inventor
Paul A Tremblay
Frank Marziani
John A F Tino
Frank G Pilkiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ES2132780T3 publication Critical patent/ES2132780T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6481—Phosphoglycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA FORMAR UNA SAL MONOVALENTE DE UN ESTER DE FOSFATIDILO QUE COMPRENDE: A) LA REACCION DE UN FOSFOLIPIDO CON UN ALCOHOL PRIMARIO EN LA PRESENCIA DE I) UNA ENZIMA CATALIZADORA FOSFOLIPASA; II) UNA SOLUCION NEUTRALIZADORA, CATIONICA, DIVALENTE Y III) UN SOLVENTE DIFERENTE AL ETER INMISCIBLE EN AGUA, DE MANERA QUE FORME EL FOSFATIDO CORRESPONDIENTE DE LA SAL CATIONICA DIVALENTE; Y B) LA CONVERSION DE LA SAL CATIONICA DIVALENTE EN UNA SAL MONOVALENTE ORGANICA, SOLUBLE MEDIANTE SUSPENSION CON UNA CANTIDAD ESTEQUIOMETRICA DE UNA SAL MONOVALENTE QUE TENGA UN CATION MONOVALENTE Y CUYO ANION FORME UN PRECIPITADO INSOLUBLE CON EL CATION DIVALENTE.
ES96100985T 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos. Expired - Lifetime ES2132780T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51328590A 1990-04-17 1990-04-17

Publications (1)

Publication Number Publication Date
ES2132780T3 true ES2132780T3 (es) 1999-08-16

Family

ID=24042616

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96100985T Expired - Lifetime ES2132780T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.
ES91908298T Expired - Lifetime ES2094811T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES91908298T Expired - Lifetime ES2094811T3 (es) 1990-04-17 1991-04-16 Sintesis enzimatica de fosfatidos solubles a partir de fosfolipidos.

Country Status (15)

Country Link
EP (2) EP0528834B1 (es)
JP (1) JP3169132B2 (es)
AT (2) ATE181747T1 (es)
AU (1) AU646458B2 (es)
CA (1) CA2080907C (es)
DE (2) DE69131404T2 (es)
DK (2) DK0727491T3 (es)
ES (2) ES2132780T3 (es)
GR (2) GR3022375T3 (es)
HU (1) HU212928B (es)
IE (1) IE911264A1 (es)
NZ (1) NZ237845A (es)
PT (1) PT97391B (es)
WO (1) WO1991016444A1 (es)
ZA (1) ZA912877B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DE10142014B4 (de) 2001-08-28 2004-11-11 Degussa Bioactives Deutschland Gmbh & Co. Kg Verfahren zur Herstellung von Phosphatidylserin
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
US6878532B1 (en) 2003-04-28 2005-04-12 Sioux Biochemical, Inc. Method of producing phosphatidylserine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900959A1 (de) * 1969-01-09 1970-08-27 Unilever Nv Verfahren zur Herstellung von Pflanzenphosphatiden mit universeller Emulgierkraft
US4235792A (en) * 1977-04-14 1980-11-25 The Governing Council Of The University Of Toronto Immunological materials
SU831129A1 (ru) * 1979-07-24 1981-05-23 Дальневосточный Государственный Уни-Верситет Способ получени фосфатидилглицерина
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4587055A (en) * 1982-05-26 1986-05-06 Research Corporation Polymerized vesicles and compounds for their preparation
US4783402A (en) * 1983-04-11 1988-11-08 Meito Sangyo Kabushiki Kaisha Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
JPS62205788A (ja) * 1986-03-05 1987-09-10 Shoichi Shimizu ホスフアチジルグリセロ−ル又はその誘導体の製造法
WO1989001524A1 (en) * 1987-08-14 1989-02-23 Liposome Technology, Inc. Method of preparing phosphatidylglycerol
US4997761A (en) * 1987-10-06 1991-03-05 Houston Biotechnology Incorporated Phosphatidyl treatment of viral disease
ES2063194T3 (es) * 1989-05-26 1995-01-01 Kao Corp Procedimiento de produccion de acido fosfatidico.

Also Published As

Publication number Publication date
DE69123145D1 (en) 1996-12-19
ATE145244T1 (de) 1996-11-15
DK0727491T3 (da) 1999-11-22
CA2080907C (en) 2001-08-14
EP0528834B1 (en) 1996-11-13
EP0727491A1 (en) 1996-08-21
DE69131404D1 (de) 1999-08-05
HU9203258D0 (en) 1993-01-28
AU646458B2 (en) 1994-02-24
EP0528834A4 (en) 1993-06-02
HU212928B (en) 1996-12-30
CA2080907A1 (en) 1991-10-18
DE69123145T2 (de) 1997-06-12
JP3169132B2 (ja) 2001-05-21
WO1991016444A1 (en) 1991-10-31
JPH05509222A (ja) 1993-12-22
PT97391B (pt) 1999-04-30
GR3022375T3 (en) 1997-04-30
DE69131404T2 (de) 1999-11-25
NZ237845A (en) 1993-06-25
GR3031059T3 (en) 1999-12-31
ZA912877B (en) 1992-12-30
AU7699591A (en) 1991-11-11
PT97391A (pt) 1991-12-31
ATE181747T1 (de) 1999-07-15
ES2094811T3 (es) 1997-02-01
HUT63198A (en) 1993-07-28
EP0528834A1 (en) 1993-03-03
DK0528834T3 (da) 1997-04-07
IE911264A1 (en) 1991-10-23
EP0727491B1 (en) 1999-06-30

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