ES2128717T3 - Procedimiento para preparar acido (l)- o (d)-homoalanin-4-il-(metil)fosfinico y sus sales, por separacion de los racematos. - Google Patents

Procedimiento para preparar acido (l)- o (d)-homoalanin-4-il-(metil)fosfinico y sus sales, por separacion de los racematos.

Info

Publication number
ES2128717T3
ES2128717T3 ES95910520T ES95910520T ES2128717T3 ES 2128717 T3 ES2128717 T3 ES 2128717T3 ES 95910520 T ES95910520 T ES 95910520T ES 95910520 T ES95910520 T ES 95910520T ES 2128717 T3 ES2128717 T3 ES 2128717T3
Authority
ES
Spain
Prior art keywords
homoalanin
salts
methyl
procedure
racemats
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95910520T
Other languages
English (en)
Inventor
Harald Knorr
Gunter Schlegel
Herbert Stark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Hoechst Schering Agrevo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Schering Agrevo GmbH filed Critical Hoechst Schering Agrevo GmbH
Application granted granted Critical
Publication of ES2128717T3 publication Critical patent/ES2128717T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/36—Racemisation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

LOS COMPUESTOS DEL TITULO SE OBTIENEN POR DISOCIACION RACEMICA DE ACIDO D,L-HOMOALANIN-4-IL-(METIL)-FOSFINICO POR PRECIPITACION DE UNA DE SUS SALES DIAESTEREOMERICAS CON BASES QUIRALES COMO QUININA O CINCHONINA. ES POSIBLE UNA MEJORA DEL RENDIMIENTO PARA OBTENER LOS ENANTIOMEROS DESEADOS POR DISOCIACION RACEMICA TRANSFORMADA, REALIZANDOSE LA PRECIPITACION DE LA SAL DIAESTEREOMERICA CON LA RACEMIZACION DEL ENANTIOMERO NO DESEADO EN PRESENCIA DE ALDEHIDOS (HETERO)AROMATICOS. EL PROCEDIMIENTO DE RACEMIZACION TAMBIEN ESTA INDICADO PARA OTROS AMINOACIDOS OPTICAMENTE ACTIVOS.
ES95910520T 1994-03-04 1995-02-24 Procedimiento para preparar acido (l)- o (d)-homoalanin-4-il-(metil)fosfinico y sus sales, por separacion de los racematos. Expired - Lifetime ES2128717T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4407197A DE4407197A1 (de) 1994-03-04 1994-03-04 Verfahren zur Herstellung von /L/-Homoalanin-4-yl-(methyl)phosphinsäure und deren Salze durch Racematspaltung

Publications (1)

Publication Number Publication Date
ES2128717T3 true ES2128717T3 (es) 1999-05-16

Family

ID=6511844

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95910520T Expired - Lifetime ES2128717T3 (es) 1994-03-04 1995-02-24 Procedimiento para preparar acido (l)- o (d)-homoalanin-4-il-(metil)fosfinico y sus sales, por separacion de los racematos.

Country Status (19)

Country Link
US (2) US5767309A (es)
EP (1) EP0748325B1 (es)
JP (1) JP4303785B2 (es)
CN (1) CN1053669C (es)
AT (1) ATE176475T1 (es)
AU (1) AU704175B2 (es)
BR (1) BR9506986A (es)
CA (1) CA2184718A1 (es)
CZ (1) CZ260196A3 (es)
DE (2) DE4407197A1 (es)
ES (1) ES2128717T3 (es)
FI (1) FI963422A0 (es)
HU (1) HU215583B (es)
IL (1) IL112851A (es)
MX (1) MX9603873A (es)
TR (1) TR28265A (es)
TW (1) TW293012B (es)
WO (1) WO1995023805A1 (es)
ZA (1) ZA951779B (es)

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KR100332399B1 (ko) * 1999-02-22 2002-04-13 김경호 메토프롤롤 라세미체로부터 메토프롤롤 에난티오머의 제조방법
DE19955283A1 (de) * 1999-11-17 2001-05-23 Aventis Res & Tech Gmbh & Co Verfahren zur enantioselektiven Gewinnung von Aminosäuren und Aminosäurederivaten unter Verwendung von Racemisierungskatalysatoren
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
CN109072261B (zh) 2016-03-02 2023-03-17 巴斯夫欧洲公司 制造l-草胺膦的方法
CN106188134B (zh) * 2016-07-01 2018-03-20 永农生物科学有限公司 一种l‑草铵膦或其盐的分离及精制方法
WO2018108797A1 (de) 2016-12-15 2018-06-21 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von l-glufosinat oder dessen salzen unter verwendung von ephedrin
WO2018108794A1 (de) 2016-12-15 2018-06-21 Bayer Cropscience Aktiengesellschaft Verfahren zur herstellung von d-glufosinat oder dessen salzen unter verwendung von ephedrin
WO2018193999A1 (ja) * 2017-04-17 2018-10-25 国立大学法人京都大学 光学活性な２－アミノ－ホスホノアルカン酸、光学活性な２－アミノ－ホスホノアルカン酸塩、及びこれらの水和物
JP2020527567A (ja) * 2017-07-18 2020-09-10 アグリメティス，エルエルシー Ｌ−グルホシネートの精製方法
CN110343676B (zh) 2018-04-03 2020-06-23 上海弈柯莱生物医药科技有限公司 一种l-谷氨酸脱氢酶突变体及其应用
CN110467580B (zh) * 2018-05-10 2020-11-13 华润赛科药业有限责任公司 雷西纳德轴手性对映体的拆分方法
EP3847269A1 (en) 2018-09-05 2021-07-14 Basf Se Methods for improving yields of l-glufosinate
CN111072718A (zh) * 2018-10-19 2020-04-28 中国药科大学 一种l－草铵膦的制备方法
CN109369713A (zh) * 2018-12-18 2019-02-22 山东省农药科学研究院 一种精草铵膦酸水合物晶体及其制备方法
WO2020214631A1 (en) 2019-04-16 2020-10-22 Agrimetis, Llc Methods for producing crystalline l-glufosinate ammonium monohydrate
CN111979208B (zh) 2019-05-23 2023-01-10 弈柯莱生物科技(上海)股份有限公司 一种l-谷氨酸脱氢酶突变体及其应用
NZ797161A (en) * 2020-07-31 2023-12-22 Upl Ltd Crystalline form of l-glufosinate ammonium salt and process for production thereof
US11555046B2 (en) 2020-07-31 2023-01-17 Upl Ltd Crystalline form of L-glufosinate ammonium salt and process for production thereof
CN113234767B (zh) * 2021-05-13 2022-05-17 永农生物科学有限公司 制备不含结晶水的l-草铵膦铵盐的固体粉末的方法
US20240270768A1 (en) * 2021-06-11 2024-08-15 Upl Limited A method for obtaining l-glufosinate
KR20240121809A (ko) 2021-12-10 2024-08-09 바스프 에스이 히단토이나제-기반 방법을 사용하는 글루포시네이트의 합성
IL313407A (en) 2021-12-10 2024-08-01 Basf Se Enzymatic decarbamoylation of glufosinate derivatives
WO2023236168A1 (zh) * 2022-06-10 2023-12-14 江苏七洲绿色科技研究院有限公司 L-草铵膦铵盐的结晶及其制备方法和应用
WO2024158883A1 (en) * 2023-01-25 2024-08-02 Vulpes Agricultural Corp. Optically active amino acid salts and method for their preparation
WO2024175643A1 (en) 2023-02-23 2024-08-29 Basf Se A process for preparing l-glufosinate from cyanhydrine or cyanhydrine derivatives

Family Cites Families (20)

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Publication number Priority date Publication date Assignee Title
US3213106A (en) * 1961-11-16 1965-10-19 Ajinomoto Kk Process of racemizing optically active alpha acids
CH551945A (de) * 1970-07-16 1974-07-31 Ciba Geigy Ag Verfahren zur herstellung der (+)-(beta)-amino-(beta)-(3,4-dimethoxy-phenyl)-propionsaeure.
US4265654A (en) * 1977-12-28 1981-05-05 Meiji Seika Kaisha Ltd. Herbicidal compositions
US4401820A (en) * 1981-01-23 1983-08-30 Tanabe Seiyaku Co., Ltd. Process for racemizing optically active α-amino acids or a salt thereof
GB8421964D0 (en) * 1984-08-30 1984-10-03 Beecham Group Plc Chemical process
DE3542645A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von l-homoalanin-4-yl(methyl)-phosphinsaeure sowie ihrer alkylester
DE3609818A1 (de) * 1986-03-22 1987-09-24 Hoechst Ag Verfahren zur herstellung von l-phosphinothricin(derivaten) sowie ihrer alkylester
DE3706022A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Verfahren zur racemisierung von optisch aktiver d-2-phenacetylamino-4-methylphosphinobuttersaeure
DE3817191A1 (de) * 1988-05-20 1989-11-30 Hoechst Ag Verfahren zur racemisierung von optisch aktiver d-2-n-phenacetylamino-4- methylphosphinobuttersaeure
DE3817956A1 (de) * 1988-05-27 1989-12-07 Hoechst Ag Verfahren zur herstellung phosphorhaltiger l-aminosaeuren sowie ihrer ester und n-derivate
DE3903446A1 (de) * 1989-02-06 1990-10-18 Hoechst Ag Verfahren zur enzymatischen trennung von 2-amino-4-methylphosphinobuttersaeurederivaten
DE3920570A1 (de) * 1989-06-23 1991-01-03 Hoechst Ag Verfahren zur isolierung von l-2-amino-4-methylphosphinobuttersaeure-ammoniumsalz aus einer enzymatischen transaminierungsloesung
DE3923650A1 (de) * 1989-07-18 1991-01-31 Hoechst Ag Verfahren zur gewinnung von l-2-amino-4-methylphosphinobuttersaeure-(salzen) durch elektrodialyse
IL98502A (en) * 1990-06-22 1998-04-05 Ciba Geigy Ag History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them
EP0499376A1 (en) * 1991-01-31 1992-08-19 Hoechst Celanese Corporation Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof
TW353663B (en) * 1991-04-06 1999-03-01 Hoechst Ag Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process
DE9202282U1 (de) * 1991-04-09 1992-04-30 Siemens AG, 8000 München Schiebeschalter
JP3212702B2 (ja) * 1991-08-03 2001-09-25 ヘキスト・アクチェンゲゼルシャフト 光学活性なω−ハロ−２−アミノアルカンカルボン酸誘導体、その製造方法および光学活性なリン含有α−アミノ酸の製造のためにそれを使用する方法
JPH05165305A (ja) * 1991-12-11 1993-07-02 Sharp Corp 帯電装置
IL104056A (en) * 1991-12-13 1997-02-18 Hoechst Ag Process for the preparation of L-phosphinothricin and its derivatives

Also Published As

Publication number Publication date
ZA951779B (en) 1995-11-09
CN1053669C (zh) 2000-06-21
IL112851A0 (en) 1995-06-29
US5767309A (en) 1998-06-16
FI963422A (fi) 1996-09-02
HUT75050A (en) 1997-03-28
BR9506986A (pt) 1997-09-16
FI963422A0 (fi) 1996-09-02
EP0748325A1 (de) 1996-12-18
DE4407197A1 (de) 1995-09-07
HU215583B (hu) 1999-01-28
WO1995023805A1 (de) 1995-09-08
TW293012B (es) 1996-12-11
AU704175B2 (en) 1999-04-15
CA2184718A1 (en) 1995-09-08
CN1143369A (zh) 1997-02-19
IL112851A (en) 2000-08-13
JPH09509924A (ja) 1997-10-07
DE59505034D1 (de) 1999-03-18
HU9602411D0 (en) 1996-11-28
US5869668A (en) 1999-02-09
TR28265A (tr) 1996-04-09
CZ260196A3 (en) 1997-02-12
MX9603873A (es) 1997-03-29
AU1759595A (en) 1995-09-18
EP0748325B1 (de) 1999-02-03
JP4303785B2 (ja) 2009-07-29
ATE176475T1 (de) 1999-02-15

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