ES2125300T3 - Granulados farmaceuticos que contienen esteroides. - Google Patents
Granulados farmaceuticos que contienen esteroides.Info
- Publication number
- ES2125300T3 ES2125300T3 ES93203476T ES93203476T ES2125300T3 ES 2125300 T3 ES2125300 T3 ES 2125300T3 ES 93203476 T ES93203476 T ES 93203476T ES 93203476 T ES93203476 T ES 93203476T ES 2125300 T3 ES2125300 T3 ES 2125300T3
- Authority
- ES
- Spain
- Prior art keywords
- carrier
- mixture
- optionally
- granules
- desogestrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA PREPARAR GRANULADOS QUE IMPLICA, PRIMERO, PREPARAR UN PORTADOR QUE COMPRENDE UN DILUYENTE, UN ENLAZANTE, Y OPCIONALMENTE UN AGENTE DESINTEGRANTE. EN UN CONTENEDOR SEPARADO DE DICHO PORTADOR, UN ESTEROIDE, LUBRICANTE Y, OPCIONALMENTE, UN ANTIOXIDANTE SE DISUELVEN EN UN DISOLVENTE ORGANICO OPCIONALMENTE PRECALENTADO. LA SOLUCION RESULTANTE SE AÑADE AL PORTADOR CONTENIDO DENTRO DE UN, V.G. MEZCLADOR DE VACIO, SEGUIDO ADEMAS POR UN AGITADO DE LA MEZCLA. EL DISOLVENTE ORGANICO SE ELIMINA DE LA MEZCLA. LA MEZCLA ADEMAS SE COMBINA PARA FORMAR GRANULOS. EL PROCESO PUEDE ADEMAS INCLUIR INCORPORAR UN INCREMENTADOR DE FLUJO TAL COMO UN DIOXIDO DE SILICONA COLOIDAL EN LOS GRANULOS. UN GRANULO PARA HACER UNA UNIDAD DE DOSIS FARMACEUTICA ES UN GRANO CARACTERIZADO EN QUE COMPRENDE: A) UN PORTADOR QUE COMPRENDE UN DILUYENTE Y UN ENLAZANTE, Y B) UNA PELICULA QUE REVISTE A DICHO PORTADOR, DICHA PELICULA COMPRENDE DESOGESTREL Y UN LUBRICANTE, Y TIENE LA CARACTERISTICA DE RETENER UN90 % DEL DESOGESTREL A UNA PRESION DE 150 MBAR Y A UNA TEMPERATURA DE 70
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/941,026 US5395627A (en) | 1992-09-04 | 1992-09-04 | Pharmaceutical granulate |
EP93203476A EP0657161B1 (en) | 1992-09-04 | 1993-12-10 | Pharmaceutical granulate containing steroids |
ZA939337A ZA939337B (en) | 1992-09-04 | 1993-12-13 | Pharmaceutical granulate |
FI935584A FI111221B (fi) | 1992-09-04 | 1993-12-13 | Menetelmä farmaseuttisten rakeiden valmistamiseksi |
CA002111320A CA2111320A1 (en) | 1992-09-04 | 1993-12-13 | Pharmaceutical granulate |
NO934584A NO306928B1 (no) | 1992-09-04 | 1993-12-13 | Fremgangsmåte for fremstilling av steroidholdige granuler, samt granuler og tablett |
NZ250443A NZ250443A (en) | 1992-09-04 | 1993-12-13 | Preparation of film coated, steroid-loaded granules |
AU52391/93A AU672447B2 (en) | 1992-09-04 | 1993-12-14 | Pharmaceutical granulate |
JP32229093A JP3720385B2 (ja) | 1992-09-04 | 1993-12-21 | 医薬顆粒 |
CN93121510A CN1050043C (zh) | 1992-09-04 | 1993-12-29 | 药物颗粒 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2125300T3 true ES2125300T3 (es) | 1999-03-01 |
Family
ID=27578967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93203476T Expired - Lifetime ES2125300T3 (es) | 1992-09-04 | 1993-12-10 | Granulados farmaceuticos que contienen esteroides. |
Country Status (15)
Country | Link |
---|---|
US (2) | US5395627A (es) |
EP (1) | EP0657161B1 (es) |
JP (1) | JP3720385B2 (es) |
CN (1) | CN1050043C (es) |
AT (1) | ATE173918T1 (es) |
AU (1) | AU672447B2 (es) |
CA (1) | CA2111320A1 (es) |
DE (1) | DE69322396T2 (es) |
DK (1) | DK0657161T3 (es) |
ES (1) | ES2125300T3 (es) |
FI (1) | FI111221B (es) |
GR (1) | GR3029273T3 (es) |
NO (1) | NO306928B1 (es) |
NZ (1) | NZ250443A (es) |
ZA (1) | ZA939337B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976570A (en) * | 1993-12-21 | 1999-11-02 | Applied Analytical Industries, Inc. | Method for preparing low dose pharmaceutical products |
US6077533A (en) * | 1994-05-25 | 2000-06-20 | Purdue Pharma L.P. | Powder-layered oral dosage forms |
IL113816A (en) * | 1994-06-08 | 1998-12-06 | Akzo Nobel Nv | Pharmaceutical preparations containing desogestral, their preparation and use |
US5994348A (en) * | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
PT833642E (pt) * | 1995-06-22 | 2002-08-30 | Akzo Nobel Nv | Comprimidos de desogestrel prensados por granulacao a seco |
WO1997004752A1 (en) * | 1995-07-26 | 1997-02-13 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions of conjugated estrogens and methods for their use |
US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
DE19652196A1 (de) * | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
DK0927556T3 (da) * | 1997-09-23 | 2000-11-20 | Akzo Nobel Nv | Coatede dosisenheder |
EP1212345B1 (en) * | 1999-04-06 | 2003-08-06 | Akzo Nobel N.V. | Orally active 7-alpha-alkyl androgens |
DE60114467T2 (de) * | 2000-12-14 | 2006-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Zubereitungen enthaltend ein steroidhormon und ein stabilisierungsmittel in nicht-kristalliner form |
US7303763B2 (en) * | 2001-02-12 | 2007-12-04 | Watson Laboratories, Inc. | Compositions for conjugated estrogens and associated methods |
US6630166B1 (en) | 2001-02-12 | 2003-10-07 | Watson Pharmaceuticals, Inc. | Compositions for conjugated estrogens and associated methods |
ES2199202T3 (es) * | 2001-07-11 | 2004-02-16 | Apr Applied Pharma Research S.A. | Granulados que contienen sustancias liposolubles y un procedimiento para su preparacion. |
TW200403075A (en) * | 2002-05-29 | 2004-03-01 | Akzo Nobel Nv | Progestagenic dosage units |
JP4756153B2 (ja) * | 2004-08-27 | 2011-08-24 | 富士製薬工業株式会社 | 低成分含量の錠剤の製造方法 |
CA2601773A1 (en) * | 2005-02-03 | 2006-08-10 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
US20070248665A1 (en) * | 2006-04-24 | 2007-10-25 | Sherman Bernard C | Compositions comprising co-precipitate of eplerenone and a water-soluble excipient |
US10952968B2 (en) * | 2012-05-14 | 2021-03-23 | Shionogi & Co., Ltd. | Preparation containing 6,7-unsaturated-7-carbamoyl morphinan derivatives |
HUE051406T2 (hu) | 2012-11-14 | 2021-03-01 | Grace W R & Co | Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók |
CN103271928A (zh) * | 2013-05-31 | 2013-09-04 | 南通联亚药业有限公司 | 一种改进去氧孕烯稳定性的处方工艺 |
CN103271927A (zh) * | 2013-05-31 | 2013-09-04 | 南通联亚药业有限公司 | 一种改进口服避孕药含量均匀性三级稀释法的工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4180560A (en) * | 1976-10-26 | 1979-12-25 | Syntex Corporation | Inert core implant pellet |
JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンd↓3類組成物 |
US5145675A (en) * | 1986-03-31 | 1992-09-08 | Advanced Polymer Systems, Inc. | Two step method for preparation of controlled release formulations |
US4786503A (en) * | 1987-04-06 | 1988-11-22 | Alza Corporation | Dosage form comprising parallel lamine |
ATE66149T1 (de) * | 1987-07-06 | 1991-08-15 | Akzo Nv | Pharmazeutische dosierungseinheit zur vorbeugung bzw. behandlung von klimakterischen beschwerden. |
IL92343A0 (en) * | 1988-12-20 | 1990-07-26 | Gist Brocades Nv | Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them |
US5035897A (en) * | 1989-09-05 | 1991-07-30 | Alza Corporation | Dosage form for delivering soluble or insoluble drugs |
US5284662A (en) * | 1990-10-01 | 1994-02-08 | Ciba-Geigy Corp. | Oral osmotic system for slightly soluble active agents |
IE71202B1 (en) * | 1990-12-17 | 1997-02-12 | Akzo Nv | Progestagen-only contraceptive |
US5200194A (en) * | 1991-12-18 | 1993-04-06 | Alza Corporation | Oral osmotic device |
MX9300110A (es) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
-
1992
- 1992-09-04 US US07/941,026 patent/US5395627A/en not_active Expired - Lifetime
-
1993
- 1993-12-10 DK DK93203476T patent/DK0657161T3/da active
- 1993-12-10 DE DE69322396T patent/DE69322396T2/de not_active Revoked
- 1993-12-10 AT AT93203476T patent/ATE173918T1/de not_active IP Right Cessation
- 1993-12-10 ES ES93203476T patent/ES2125300T3/es not_active Expired - Lifetime
- 1993-12-10 EP EP93203476A patent/EP0657161B1/en not_active Revoked
- 1993-12-13 NZ NZ250443A patent/NZ250443A/en not_active IP Right Cessation
- 1993-12-13 ZA ZA939337A patent/ZA939337B/xx unknown
- 1993-12-13 CA CA002111320A patent/CA2111320A1/en not_active Abandoned
- 1993-12-13 NO NO934584A patent/NO306928B1/no not_active IP Right Cessation
- 1993-12-13 FI FI935584A patent/FI111221B/fi not_active IP Right Cessation
- 1993-12-14 AU AU52391/93A patent/AU672447B2/en not_active Expired
- 1993-12-21 JP JP32229093A patent/JP3720385B2/ja not_active Expired - Lifetime
- 1993-12-29 CN CN93121510A patent/CN1050043C/zh not_active Expired - Lifetime
-
1994
- 1994-12-29 US US08/366,348 patent/US5527543A/en not_active Expired - Lifetime
-
1999
- 1999-02-03 GR GR990400353T patent/GR3029273T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0657161B1 (en) | 1998-12-02 |
NO306928B1 (no) | 2000-01-17 |
NO934584L (no) | 1995-06-14 |
AU5239193A (en) | 1995-07-13 |
DK0657161T3 (da) | 1999-08-16 |
DE69322396T2 (de) | 1999-07-29 |
NZ250443A (en) | 1995-07-26 |
JP3720385B2 (ja) | 2005-11-24 |
DE69322396D1 (de) | 1999-01-14 |
CA2111320A1 (en) | 1995-06-14 |
FI935584A0 (fi) | 1993-12-13 |
GR3029273T3 (en) | 1999-05-28 |
EP0657161A1 (en) | 1995-06-14 |
NO934584D0 (no) | 1993-12-13 |
CN1104487A (zh) | 1995-07-05 |
JPH07196513A (ja) | 1995-08-01 |
AU672447B2 (en) | 1996-10-03 |
ATE173918T1 (de) | 1998-12-15 |
US5527543A (en) | 1996-06-18 |
US5395627A (en) | 1995-03-07 |
FI111221B (fi) | 2003-06-30 |
FI935584A (fi) | 1995-06-14 |
ZA939337B (en) | 1994-10-13 |
CN1050043C (zh) | 2000-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2125300T3 (es) | Granulados farmaceuticos que contienen esteroides. | |
KR950031056A (ko) | 에스트로겐 및/또는 프로게스토겐을 투여하기 위한 eva로 이루어진 경피성 매트릭스 시스템 | |
AU2095092A (en) | New arylethylamine compounds, processes for the preparation thereof, and pharmaceutical compositions containing them | |
YU48666B (sh) | Mometason furoat monohidrat i postupak za njegovo dobijanje | |
JPS57180602A (en) | Production of water-soluble chitosan derivative and film-forming agent comprising same | |
KR900013950A (ko) | (7α,17α)-17-히드록시-7-메틸-19-노르-17-프레근-5(10)-엔-20-인-3-온 화합물 및 약학적 담체를 함유한 약학적 조성물 | |
BE900241A (fr) | Procede de preparation d'ester de a-acetoxyethyle de cefuroxime. | |
Montenegro et al. | Studies on the Pauson–Khand reaction of alkynyl sulfoxides. Unexpectedly easy racemization of their dicobalt hexacarbonyl complexes | |
KR880001237B1 (ko) | 베클로메타손 17,21-디프로피오네이트의 용매화합물의 제조방법 | |
GR3023311T3 (en) | 17B-(3-Furyl) and 17B-(4-pyridazinyl)-5beta,14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | |
DE60031557D1 (de) | Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen | |
EP0401894B1 (en) | Freeze-dried, powdery cyclophosphamide composition, as well as process for its preparation | |
KR950016749A (ko) | 약제용 과립 및 그 제조 방법 | |
US3133858A (en) | Stable thiobarbituric acid solution | |
AU1895483A (en) | Mg/zn diketonate complexes adducted with thf | |
GEP20002095B (en) | Antracycline Disaccharides, Process for Their Preparation and Pharmaceutical Compositions | |
JPH02121957A (ja) | 包接化合物 | |
TH14841EX (th) | แกรนูลยา | |
Cunico et al. | A Phenylcarbene Transfer System | |
US3629240A (en) | 17beta-(1-cycloalkenyl) oxy-2alpha 3alpha-epithio-5alpha-androstanes | |
ATE30712T1 (de) | 4-hydroxy-alpha-aethyl-benzhydrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. | |
JPS54125651A (en) | Monocyclic beta-lactam derivative and its preparation | |
JPS5655362A (en) | Polyfunctional azide compound and its preparation | |
TH21945B (th) | แกรนูลยา | |
JPS5626832A (en) | Preparation of cyclopentenolone |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 657161 Country of ref document: ES |