ES2122516T3 - Analogos de acido nucleico con funcionalidad formadora de quelatos. - Google Patents

Analogos de acido nucleico con funcionalidad formadora de quelatos.

Info

Publication number
ES2122516T3
ES2122516T3 ES95902082T ES95902082T ES2122516T3 ES 2122516 T3 ES2122516 T3 ES 2122516T3 ES 95902082 T ES95902082 T ES 95902082T ES 95902082 T ES95902082 T ES 95902082T ES 2122516 T3 ES2122516 T3 ES 2122516T3
Authority
ES
Spain
Prior art keywords
nucleic acid
acid analogs
chelate forming
forming functionality
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902082T
Other languages
English (en)
Inventor
Christopher John Stanley
Henrik Orum
Mikkel Jorgensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PNA Diagnostics ApS Denmark
Original Assignee
PNA Diagnostics ApS Denmark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PNA Diagnostics ApS Denmark filed Critical PNA Diagnostics ApS Denmark
Application granted granted Critical
Publication of ES2122516T3 publication Critical patent/ES2122516T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN ACIDO NUCLEICO ANALOGO QUE COMPRENDE UN HAZ POLIMERICO QUE INCLUYE UNA SECUENCIA DE LIGANDOS UNIDOS A UNA ESPINA DORSAL HECHA DE MITADES DE ESPINA DORSAL UNIDAS. DICHO ANALOGO ES CAPAZ DE HIBRIDAR A UN ACIDO NUCLEICO DE SECUENCIA COMPLEMENTARIA, QUE COMPRENDE ADEMAS UNA MITAD QUELANTE CAPAZ DE UNIR AL MENOS UN ION DE METAL POR QUELACION.
ES95902082T 1993-11-25 1994-11-22 Analogos de acido nucleico con funcionalidad formadora de quelatos. Expired - Lifetime ES2122516T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9324243A GB2284208A (en) 1993-11-25 1993-11-25 Nucleic acid analogues with a chelating functionality for metal ions

Publications (1)

Publication Number Publication Date
ES2122516T3 true ES2122516T3 (es) 1998-12-16

Family

ID=10745682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902082T Expired - Lifetime ES2122516T3 (es) 1993-11-25 1994-11-22 Analogos de acido nucleico con funcionalidad formadora de quelatos.

Country Status (14)

Country Link
US (2) US5843663A (es)
EP (1) EP0730602B1 (es)
JP (1) JPH09504050A (es)
KR (1) KR0169873B1 (es)
AT (1) ATE169632T1 (es)
AU (1) AU684118B2 (es)
CA (1) CA2176745C (es)
DE (1) DE69412509T2 (es)
DK (1) DK0730602T3 (es)
ES (1) ES2122516T3 (es)
GB (1) GB2284208A (es)
IL (1) IL111733A (es)
WO (1) WO1995014708A1 (es)
ZA (1) ZA949317B (es)

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DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
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US6914137B2 (en) * 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
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WO2000073764A2 (en) 1999-06-01 2000-12-07 Baylor College Of Medicine Composition and methods for the therapeutic use of an atonal-associated sequence
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US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
EP1325125B1 (en) 2000-07-10 2013-06-05 Board Of Regents, The University Of Texas System Chromosome 3p21.3 genes are tumor suppressors
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
WO2003062786A2 (en) * 2001-08-20 2003-07-31 Regenesis Bioremediation Products Biosensor for small molecule analytes
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
EP1468116A2 (en) 2002-01-16 2004-10-20 Dynal Biotech ASA Method for isolating nucleic acids and protein from a single sample
KR20120002613A (ko) 2002-08-12 2012-01-06 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
PL212483B1 (pl) * 2002-09-27 2012-10-31 Powderject Res Ltd Sposób wytwarzania czasteczek, czasteczki odpowiednie do dostarczania, pojemnik, urzadzenie do dostarczania czasteczek i zastosowanie tych czasteczek
US20050009051A1 (en) * 2002-09-27 2005-01-13 Board Of Regents, The University Of Texas Diagnosis of mould infection
US20050123932A1 (en) * 2003-12-09 2005-06-09 Mekbib Astatke Nucleic acid-chelating agent conjugates
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
US20050241959A1 (en) * 2004-04-30 2005-11-03 Kenneth Ward Chemical-sensing devices
EP1759009A1 (en) * 2004-05-28 2007-03-07 Board Of Regents, The University Of Texas System Multigene predictors of response to chemotherapy
ATE469245T1 (de) 2004-09-14 2010-06-15 Univ Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
JP2009507853A (ja) 2005-09-07 2009-02-26 ジェンネレックス インコーポレイティッド Ｇｍ−ｃｓｆ発現ポックスウイルスを用いる転移性および／または全身播種性癌の全身処置
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
ES2741138T3 (es) 2006-09-15 2020-02-10 Childrens Hospital Of Eastern Ontario Res Institute Inc Rhabdovirus oncolítico de Farmington
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
EP2055385B1 (en) 2007-10-31 2010-05-26 Roche Diagnostics GmbH Method and device for purifying nucleic acids
US20090162845A1 (en) 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
EP2857525B1 (en) * 2008-02-29 2019-04-10 Oxford University Innovation Limited A method of determining a suitable dosage of statin.
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US8470541B1 (en) 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
ES2671570T3 (es) 2009-09-14 2018-06-07 Sillajen Biotherapeutics, Inc. Terapia combinada contra el cáncer con virus oncolítico de vaccinia
US9045729B2 (en) 2009-12-10 2015-06-02 Ottawa Hospital Research Institute Oncolytic rhabdovirus
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US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
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US9364532B2 (en) 2011-06-08 2016-06-14 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
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US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
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US11733242B2 (en) 2018-10-31 2023-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
CN112876580B (zh) * 2021-03-11 2022-12-27 山西奥睿基赛生物科技有限公司 一种腐殖酸去除剂、其制备方法及应用

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CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
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ES2075402T3 (es) * 1991-07-22 1995-10-01 Bracco Int Bv Conjugados quelados con metales paramagneticos para enfoque deliberado.
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding

Also Published As

Publication number Publication date
IL111733A (en) 2001-07-24
EP0730602B1 (en) 1998-08-12
AU1107595A (en) 1995-06-13
KR0169873B1 (ko) 1999-01-15
EP0730602A1 (en) 1996-09-11
ATE169632T1 (de) 1998-08-15
DK0730602T3 (da) 1999-05-10
CA2176745A1 (en) 1995-06-01
US20010047077A1 (en) 2001-11-29
US6346378B2 (en) 2002-02-12
CA2176745C (en) 2004-05-25
JPH09504050A (ja) 1997-04-22
AU684118B2 (en) 1997-12-04
US5843663A (en) 1998-12-01
IL111733A0 (en) 1995-01-24
KR960705836A (ko) 1996-11-08
GB2284208A (en) 1995-05-31
ZA949317B (en) 1996-05-24
DE69412509T2 (de) 1999-01-28
WO1995014708A1 (en) 1995-06-01
DE69412509D1 (de) 1998-09-17
GB9324243D0 (en) 1994-01-12

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