DE69412509D1 - Nukleinsäureanaloga mit chelatisierender funktionalität - Google Patents

Nukleinsäureanaloga mit chelatisierender funktionalität

Info

Publication number
DE69412509D1
DE69412509D1 DE69412509T DE69412509T DE69412509D1 DE 69412509 D1 DE69412509 D1 DE 69412509D1 DE 69412509 T DE69412509 T DE 69412509T DE 69412509 T DE69412509 T DE 69412509T DE 69412509 D1 DE69412509 D1 DE 69412509D1
Authority
DE
Germany
Prior art keywords
nucleic acid
chelatizing
functionality
analoga
acid analoga
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69412509T
Other languages
English (en)
Other versions
DE69412509T2 (de
Inventor
Christopher Stanley
Henrik Orum
Mikkel Jorgensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PNA Diagnostics ApS Denmark
Original Assignee
PNA Diagnostics ApS Denmark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PNA Diagnostics ApS Denmark filed Critical PNA Diagnostics ApS Denmark
Publication of DE69412509D1 publication Critical patent/DE69412509D1/de
Application granted granted Critical
Publication of DE69412509T2 publication Critical patent/DE69412509T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69412509T 1993-11-25 1994-11-22 Nukleinsäureanaloga mit chelatisierender funktionalität Expired - Lifetime DE69412509T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9324243A GB2284208A (en) 1993-11-25 1993-11-25 Nucleic acid analogues with a chelating functionality for metal ions
PCT/EP1994/003859 WO1995014708A1 (en) 1993-11-25 1994-11-22 Nucleic acid analogs with a chelating functionality

Publications (2)

Publication Number Publication Date
DE69412509D1 true DE69412509D1 (de) 1998-09-17
DE69412509T2 DE69412509T2 (de) 1999-01-28

Family

ID=10745682

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69412509T Expired - Lifetime DE69412509T2 (de) 1993-11-25 1994-11-22 Nukleinsäureanaloga mit chelatisierender funktionalität

Country Status (14)

Country Link
US (2) US5843663A (de)
EP (1) EP0730602B1 (de)
JP (1) JPH09504050A (de)
KR (1) KR0169873B1 (de)
AT (1) ATE169632T1 (de)
AU (1) AU684118B2 (de)
CA (1) CA2176745C (de)
DE (1) DE69412509T2 (de)
DK (1) DK0730602T3 (de)
ES (1) ES2122516T3 (de)
GB (1) GB2284208A (de)
IL (1) IL111733A (de)
WO (1) WO1995014708A1 (de)
ZA (1) ZA949317B (de)

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WO1998000435A2 (en) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
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US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
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DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
WO2000044928A2 (en) * 1999-01-27 2000-08-03 Halaka Folim G Materials and methods for the purification of polyelectrolytes
EP1471926B8 (de) 1999-06-01 2011-09-21 Baylor College Of Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
WO2001016352A1 (en) * 1999-08-27 2001-03-08 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins
US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
AU2001273337B2 (en) 2000-07-10 2006-06-29 Board Of Regents, The University Of Texas System Chromosome 3p21.3 genes are tumor suppressors
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
ATE365211T1 (de) * 2001-08-20 2007-07-15 Regenesis Bioremediation Produ Biosensor für kleinmolekulare analyten
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
EP1468116A2 (de) 2002-01-16 2004-10-20 Dynal Biotech ASA Verfahren zur isolierung von nukleinsäuren und proteinen aus einer einzigen probe
EP2044948B1 (de) 2002-08-12 2013-10-30 Jennerex Biotherapeutics ULC Vacciniaviren zur Anwendung in der Behandlung von Krebs
KR101152561B1 (ko) * 2002-09-27 2012-06-01 파우더젝트 리서치 리미티드 핵산 코팅된 입자
US20050009051A1 (en) * 2002-09-27 2005-01-13 Board Of Regents, The University Of Texas Diagnosis of mould infection
US20050123932A1 (en) * 2003-12-09 2005-06-09 Mekbib Astatke Nucleic acid-chelating agent conjugates
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
US20050241959A1 (en) * 2004-04-30 2005-11-03 Kenneth Ward Chemical-sensing devices
WO2005118858A1 (en) * 2004-05-28 2005-12-15 Board Of Regents, The University Of Texas System Multigene predictors of response to chemotherapy
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CA2621982C (en) 2005-09-07 2017-11-28 Jennerex Biotherapeutics Ulc Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
CN102026645B (zh) 2006-09-15 2016-01-27 渥太华医院研究机构 溶瘤弹状病毒
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
DE602008001350D1 (de) 2007-10-31 2010-07-08 Roche Diagnostics Gmbh Verfahren und Vorrichtung zur Reinigung von Nukleinsäuren
US20090162845A1 (en) 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
JP2011512813A (ja) 2008-02-29 2011-04-28 アイシス イノベーション リミテッド 診断法
GB0804495D0 (en) * 2008-03-11 2008-04-16 Iti Scotland Ltd Surface attachment
US9817001B2 (en) 2008-05-27 2017-11-14 Boston Heart Diagnostics Corporation Methods for determining LDL cholesterol treatment
US8470541B1 (en) 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
ES2848650T3 (es) 2009-09-14 2021-08-11 Sillajen Biotherapeutics Inc Terapia combinada contra el cáncer con virus vaccinia oncolítico
CN102858959B (zh) 2009-12-10 2016-02-24 渥太华医院研究院 溶瘤弹状病毒
US20130131161A1 (en) 2009-12-23 2013-05-23 Michael R. Bristow Methods and compositions for cardiovascular diseases and conditions
JP6121910B2 (ja) 2011-01-04 2017-04-26 シラジェン バイオセラピューティクス インコーポレイテッド 腫瘍溶解性ワクシニアウイルスの投与による腫瘍抗原に対する抗体の生成および腫瘍特異的補体依存性細胞傷害の生成
MX2013009863A (es) 2011-02-28 2013-12-06 Univ Iowa Res Found Cambios de la hormona anti-mulleriana en el embarazo y prediccion de sexo y de resultados adversos en el embarazo.
CA2829300A1 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
ES2627529T3 (es) 2011-06-08 2017-07-28 Children's Hospital Of Eastern Ontario Research Institute Inc. Composiciones para tratamiento de glioblastoma
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
EP2766728B1 (de) 2011-10-13 2017-09-06 Boston Heart Diagnostics Zusammensetzungen und verfahren zur behandlung und prävention von koronarer herzkrankheit
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US10363293B2 (en) 2013-02-21 2019-07-30 Turnstone Limited Partnership Vaccine composition
US9828624B2 (en) 2013-07-24 2017-11-28 Boston Heart Diagnostics Corporation Driving patient compliance with therapy
US9739790B2 (en) 2014-11-17 2017-08-22 Boston Heart Diagnostic Corporation Cardiovascular disease risk assessment
EP3224362A4 (de) 2014-11-26 2018-06-06 The Regents of The University of California Therapeutische zusammensetzungen mit transkriptionsfaktoren sowie verfahren zur herstellung und verwendung davon
AU2019371161A1 (en) 2018-10-31 2021-06-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
CN112876580B (zh) * 2021-03-11 2022-12-27 山西奥睿基赛生物科技有限公司 一种腐殖酸去除剂、其制备方法及应用

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US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
WO1993024511A1 (en) * 1992-05-29 1993-12-09 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
JPH05505201A (ja) * 1991-02-14 1993-08-05 バクスター、ダイアグノスチックス、インコーポレイテッド 新規なランタナイドキレート結合オリゴヌクレオチド
WO1992021151A2 (en) * 1991-05-10 1992-11-26 Q-Dot, Inc. HIGH-SPEED PERISTALTIC CCD IMAGER WITH GaAs FET OUTPUT
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
EP0529175B1 (de) * 1991-07-22 1995-08-09 BRACCO International B.V. Anwendung von Chelaten von Konjugaten mit paramagnetischen Metallen für Targetting
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding

Also Published As

Publication number Publication date
ATE169632T1 (de) 1998-08-15
IL111733A0 (en) 1995-01-24
ES2122516T3 (es) 1998-12-16
CA2176745A1 (en) 1995-06-01
GB2284208A (en) 1995-05-31
AU684118B2 (en) 1997-12-04
US5843663A (en) 1998-12-01
KR0169873B1 (ko) 1999-01-15
US6346378B2 (en) 2002-02-12
IL111733A (en) 2001-07-24
EP0730602B1 (de) 1998-08-12
CA2176745C (en) 2004-05-25
AU1107595A (en) 1995-06-13
EP0730602A1 (de) 1996-09-11
WO1995014708A1 (en) 1995-06-01
GB9324243D0 (en) 1994-01-12
DK0730602T3 (da) 1999-05-10
US20010047077A1 (en) 2001-11-29
DE69412509T2 (de) 1999-01-28
JPH09504050A (ja) 1997-04-22
ZA949317B (en) 1996-05-24
KR960705836A (ko) 1996-11-08

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Legal Events

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