ES2115665T3 - Derivado de triterpeno. - Google Patents

Derivado de triterpeno.

Info

Publication number
ES2115665T3
ES2115665T3 ES92900597T ES92900597T ES2115665T3 ES 2115665 T3 ES2115665 T3 ES 2115665T3 ES 92900597 T ES92900597 T ES 92900597T ES 92900597 T ES92900597 T ES 92900597T ES 2115665 T3 ES2115665 T3 ES 2115665T3
Authority
ES
Spain
Prior art keywords
hydrogen
triterpen
derived
formula
antiendotheline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92900597T
Other languages
English (en)
Spanish (es)
Inventor
Masafumi Fujimoto
Kensuke Sakurai
Shinichi Mihara
Miharu Nakamura
Toshiro Konoike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2115665T3 publication Critical patent/ES2115665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
ES92900597T 1991-01-29 1991-12-13 Derivado de triterpeno. Expired - Lifetime ES2115665T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2937291 1991-01-29

Publications (1)

Publication Number Publication Date
ES2115665T3 true ES2115665T3 (es) 1998-07-01

Family

ID=12274319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92900597T Expired - Lifetime ES2115665T3 (es) 1991-01-29 1991-12-13 Derivado de triterpeno.

Country Status (8)

Country Link
US (1) US5248807A (Sortimente)
EP (1) EP0526642B1 (Sortimente)
JP (1) JP2950616B2 (Sortimente)
AT (1) ATE164588T1 (Sortimente)
DE (1) DE69129193T2 (Sortimente)
DK (1) DK0526642T3 (Sortimente)
ES (1) ES2115665T3 (Sortimente)
WO (1) WO1992012991A1 (Sortimente)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
AU4376893A (en) * 1992-05-19 1993-12-13 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
FI941826L (fi) * 1993-04-21 1994-10-22 Takeda Chemical Industries Ltd Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JP3373591B2 (ja) 1993-06-11 2003-02-04 塩野義製薬株式会社 硫酸化トリテルペン誘導体およびそれを含有するエンドセリンレセプター拮抗剤
ES2116663T3 (es) * 1993-06-11 1998-07-16 Shionogi & Co Compuestos intermediarios para la preparacion de derivados triterpenos antagonistas del receptor de endotelina.
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
KR100399797B1 (ko) * 1995-06-02 2004-04-13 시오노기세이야쿠가부시키가이샤 뇌부종억제제
US5977117A (en) 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
IL131318A (en) 1997-04-28 2004-08-31 Encysive Pharmaceuticals Inc Pharmaceutically acceptable salts of sulfonamides for treatment of endothelin-mediated disorders
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
DE60034605T2 (de) 1999-12-31 2007-09-06 Encysive Pharmaceuticals, Inc., Houston Sulfonamide und deren Derivate als Modulatoren der Endothelin-Aktivität
EP1489091A4 (en) * 2002-03-22 2009-06-17 Shionogi & Co METHOD FOR PRODUCING A TRITERPENDERIVATE
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
JP4827189B2 (ja) 2004-05-14 2011-11-30 塩野義製薬株式会社 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
EP2281859B1 (en) * 2004-12-21 2014-03-26 Dow Global Technologies LLC Polypropylene-based adhesive compounds
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
CN101404981A (zh) * 2006-03-13 2009-04-08 恩希赛弗制药公司 治疗舒张性心力衰竭的方法和组合物
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases
EP3492077A1 (en) 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
AU2009237578C1 (en) 2008-04-18 2014-12-04 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
CN103342729B (zh) * 2013-03-26 2016-09-14 中国科学院上海药物研究所 咖啡酰基取代的五环三萜类衍生物及其用途
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals Inc métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
EP3735274A1 (en) 2018-01-04 2020-11-11 Amryt Research Limited Betulin-containing birch bark extracts and their formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
JPS63222119A (ja) * 1987-03-10 1988-09-16 Rooman Kogyo:Kk 肝臓疾患用剤
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
DK0526642T3 (da) 1998-10-19
EP0526642A1 (en) 1993-02-10
EP0526642B1 (en) 1998-04-01
EP0526642A4 (Sortimente) 1994-02-09
DE69129193D1 (en) 1998-05-07
US5248807A (en) 1993-09-28
ATE164588T1 (de) 1998-04-15
DE69129193T2 (de) 1998-07-30
JP2950616B2 (ja) 1999-09-20
WO1992012991A1 (fr) 1992-08-06

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