ES2115134T3 - Procedimiento para la preparacion de 5-cloroimidazol-4-carbaldehidos 2-sustituidos. - Google Patents

Procedimiento para la preparacion de 5-cloroimidazol-4-carbaldehidos 2-sustituidos.

Info

Publication number
ES2115134T3
ES2115134T3 ES94117951T ES94117951T ES2115134T3 ES 2115134 T3 ES2115134 T3 ES 2115134T3 ES 94117951 T ES94117951 T ES 94117951T ES 94117951 T ES94117951 T ES 94117951T ES 2115134 T3 ES2115134 T3 ES 2115134T3
Authority
ES
Spain
Prior art keywords
substituted
chloroimidazole
preparation
carbaldehyde
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94117951T
Other languages
English (en)
Inventor
Dr Gareth Griffiths
Dr Jacques Gosteli
Dr Rene Imwinkelried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2115134T3 publication Critical patent/ES2115134T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA ELABORACION DEL 2 SUSTITUIDO. 5 ULA GENERAL DONDE UN HIDROHALOGENURO DE ESTER GLICINA SE TRANSFORMA CON UN ESTER DE ACIDO IMIDA PARA LA FORMACION DE UN 2 SUSTITUIDO. 3,5 CON UN N,N ACETAL FORMAMIDA SUSTITUIDA EN DONDE EL N,N TUIDO AMINOMETILENIMIDAZOLANINONA SE TRANSFORMA Y FINALMENTE SE SOMETE A PROCESO DE CLORACION. LOS 5 BALDEHIDO SON PRODUCTOS INTERMEDIOS IMPORTANTES EN LA ELABORACION DE PRODUCTOS FARMACEUTICOS PARA LA REDUCCION DE LA PRESION ARTERIAL.
ES94117951T 1993-11-15 1994-11-14 Procedimiento para la preparacion de 5-cloroimidazol-4-carbaldehidos 2-sustituidos. Expired - Lifetime ES2115134T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH341093 1993-11-15

Publications (1)

Publication Number Publication Date
ES2115134T3 true ES2115134T3 (es) 1998-06-16

Family

ID=4255388

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94117951T Expired - Lifetime ES2115134T3 (es) 1993-11-15 1994-11-14 Procedimiento para la preparacion de 5-cloroimidazol-4-carbaldehidos 2-sustituidos.

Country Status (11)

Country Link
US (2) US5486617A (es)
EP (1) EP0653422B1 (es)
JP (1) JP3924795B2 (es)
KR (1) KR100343825B1 (es)
AT (1) ATE163411T1 (es)
CA (1) CA2135541C (es)
DE (1) DE59405299D1 (es)
DK (1) DK0653422T3 (es)
ES (1) ES2115134T3 (es)
HU (1) HU223139B1 (es)
RU (1) RU94040184A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (ja) 1996-01-05 2008-06-18 ロンザ リミテッド ２−置換５−クロロイミダゾール−４−カルブアルデヒドの製造方法
US20040126337A1 (en) * 2002-12-30 2004-07-01 Singleton Laura C. Sunscreen compositions
US20080200690A1 (en) * 2005-04-15 2008-08-21 Dishman Pharmaceuticals And Chemicals Ltd Preparation of 2-Substituted 4-Chloro-5-Formylimidazole and 5-Formylimidazole
CN101838242B (zh) * 2010-05-16 2015-07-15 浙江工业大学 2-正丁基-4-氯-5-甲酰基咪唑的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL53783A (en) * 1977-02-03 1982-08-31 American Cyanamid Co Imidazo(1,5-d)-as-triazine-4 (3h)-(thi)one derivatives,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative

Also Published As

Publication number Publication date
HU223139B1 (hu) 2004-03-29
HUT70047A (en) 1995-09-28
CA2135541A1 (en) 1995-05-16
RU94040184A (ru) 1996-10-10
HU9403263D0 (en) 1995-01-30
KR950014076A (ko) 1995-06-15
EP0653422B1 (de) 1998-02-25
DE59405299D1 (de) 1998-04-02
US5486617A (en) 1996-01-23
JP3924795B2 (ja) 2007-06-06
KR100343825B1 (ko) 2002-11-23
EP0653422A1 (de) 1995-05-17
JPH07188180A (ja) 1995-07-25
ATE163411T1 (de) 1998-03-15
CA2135541C (en) 2006-01-10
US5536841A (en) 1996-07-16
DK0653422T3 (da) 1998-05-11

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