ES2114116T3 - Analogos de vitamina d3. - Google Patents

Analogos de vitamina d3.

Info

Publication number
ES2114116T3
ES2114116T3 ES94117921T ES94117921T ES2114116T3 ES 2114116 T3 ES2114116 T3 ES 2114116T3 ES 94117921 T ES94117921 T ES 94117921T ES 94117921 T ES94117921 T ES 94117921T ES 2114116 T3 ES2114116 T3 ES 2114116T3
Authority
ES
Spain
Prior art keywords
agents
treatment
compounds
analogs
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94117921T
Other languages
English (en)
Inventor
Thomas I Doran
Bernard Michael Hennessy
John Arthur Mclane
Giacomo Pizzolato
Farhad Sedarati
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2114116T3 publication Critical patent/ES2114116T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) EN DONDE R ES HIDROGENO, HIDROXIDO, O FLUOR, X ES H2 O =CH2, Y EL ENLACE DOBLE 23, 24 ES E O Z, LOS COMPUESTOS SON UTILES COMO AGENTES PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS DE LA PIEL, TALES COMO LA PSORIASIS, COMO AGENTES PARA EL TRATAMIENTO DE TUMORES, TALES COMO EL CANCER DE PULMON, COMO AGENTES PARA EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS TALES COMO LA LEUCEMIA Y COMO AGENTES PARA EL TRATAMIENTO DE ENFERMEDADES DE LAS GLANDULAS SEBACEAS, TALES COMO EL ACNE O LA DERMATITIS SEBORREICA. LOS COMPUESTOS SE PREPARAN ELIMINANDO LOS GRUPOS PROTECTORES DE SILILO DE LOS CORRESPONDIENTES COMPUESTOS CON GRUPOS DE HIDROXIDO PROTEGIDOS CON SILILO.
ES94117921T 1993-11-24 1994-11-14 Analogos de vitamina d3. Expired - Lifetime ES2114116T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/158,068 US5428029A (en) 1993-11-24 1993-11-24 Vitamin D3 fluorinated analogs

Publications (1)

Publication Number Publication Date
ES2114116T3 true ES2114116T3 (es) 1998-05-16

Family

ID=22566563

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94117921T Expired - Lifetime ES2114116T3 (es) 1993-11-24 1994-11-14 Analogos de vitamina d3.

Country Status (15)

Country Link
US (1) US5428029A (es)
EP (1) EP0654467B1 (es)
JP (1) JP2602633B2 (es)
CN (1) CN1049653C (es)
AT (1) ATE163179T1 (es)
AU (1) AU686251B2 (es)
CA (1) CA2135708C (es)
DE (1) DE69408516T2 (es)
DK (1) DK0654467T3 (es)
ES (1) ES2114116T3 (es)
GR (1) GR3026717T3 (es)
NZ (1) NZ264925A (es)
PH (1) PH31321A (es)
RU (1) RU2134260C1 (es)
ZA (1) ZA949149B (es)

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CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
CA2175881A1 (en) * 1995-05-09 1996-11-10 Andrzej Kutner Vitamin d compounds and methods of preparing these compounds
EP0873126A4 (en) * 1995-12-29 2000-04-19 A And D Assay Inc BRANDED VITAMIN COMPOUNDS AND THEIR USE
US5747479A (en) * 1996-01-03 1998-05-05 Hoffmann-La Roche Inc. Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
KR100573234B1 (ko) * 1996-12-20 2006-04-24 쥬가이 세이야쿠 가부시키가이샤 16-엔-비타민 ｄ 유도체
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
US6100294A (en) * 1997-05-16 2000-08-08 Women And Infants Hospital Cyclic ether vitamin D3 compounds, 1α(OH) 3-epi-vitamin D3 compounds and uses thereof
EP0981514B1 (en) * 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
US20020076442A1 (en) * 1997-09-02 2002-06-20 Martin Burke Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
EP0957098A1 (en) * 1998-05-14 1999-11-17 F. Hoffmann-La Roche Ag Intermediates for the synthesis of 3-epi vitamin D3 metabolites and analogs
US6043386A (en) * 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3
AU3390400A (en) * 1999-03-05 2000-09-21 Johns Hopkins University, The Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US7122533B2 (en) * 1999-11-29 2006-10-17 The United States Of America As Represented By The Department Of Health And Human Services Cosalane compounds and methods for their use
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
IL152942A (en) * 2000-05-31 2007-09-20 Wisconsin Alumni Res Found Compounds 2 - Ethyl and 2 - Ethylaidine - 19 - Nur - Vitamin D and pharmaceutical preparations containing them
US20040214803A1 (en) * 2001-05-22 2004-10-28 Luciano Adorini Use of vitamin d3 analogue for the treatment of autoimmune diabetes
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
US20080260834A1 (en) * 2002-08-20 2008-10-23 Martin Burke Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
WO2004054968A2 (en) * 2002-12-18 2004-07-01 Johns Hopkins University 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
AU2004230948A1 (en) * 2003-04-10 2004-10-28 Wisconsin Alumni Research Foundation 2-propylidene-19-nor-vitamin D compounds
US7332482B2 (en) 2003-09-24 2008-02-19 Bioxell S.P.A. Method for treating benign prostatic hyperplasia
BRPI0508333A (pt) * 2004-03-01 2007-07-17 Bioxell Spa uso de um composto de vitamina d, método de prevenir e/ou tratar cistite intersticial, formulação farmacêutica, composto de vitamina d, e, kit
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
WO2006113990A2 (en) * 2005-04-25 2006-11-02 Cytochroma Inc. LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1α ,25-DIHYDROXY VITAMIN D3
AU2006295085A1 (en) * 2005-09-22 2007-04-05 Wisconsin Alumni Research Foundation 19,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
US8754067B2 (en) 2010-11-12 2014-06-17 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
JP6830599B2 (ja) * 2017-03-28 2021-02-17 関東電化工業株式会社 モノヒドロペルフルオロアルカンを出発原料としたペルフルオロアルキル化剤の新規製造法、及びそれらを用いた芳香族ペルフルオロアルキル化合物の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
JPH075542B2 (ja) * 1988-09-14 1995-01-25 呉羽化学工業株式会社 ビタミンｄ▲下３▼誘導体及びその製造方法
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs

Also Published As

Publication number Publication date
EP0654467A2 (en) 1995-05-24
NZ264925A (en) 1996-05-28
EP0654467A3 (en) 1995-11-08
GR3026717T3 (en) 1998-07-31
CA2135708A1 (en) 1995-05-25
AU686251B2 (en) 1998-02-05
JP2602633B2 (ja) 1997-04-23
CN1049653C (zh) 2000-02-23
CA2135708C (en) 2006-01-03
ATE163179T1 (de) 1998-02-15
JPH07188159A (ja) 1995-07-25
DE69408516T2 (de) 1998-07-02
AU7890394A (en) 1995-06-01
DK0654467T3 (da) 1998-09-23
CN1108245A (zh) 1995-09-13
EP0654467B1 (en) 1998-02-11
US5428029A (en) 1995-06-27
RU2134260C1 (ru) 1999-08-10
DE69408516D1 (de) 1998-03-19
ZA949149B (en) 1995-05-24
PH31321A (en) 1998-07-06
RU94041201A (ru) 1996-10-10

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