ES2065745T3 - Sintesis de compuestos de 1alfa-hidroxi-secosterol. - Google Patents
Sintesis de compuestos de 1alfa-hidroxi-secosterol.Info
- Publication number
- ES2065745T3 ES2065745T3 ES92302077T ES92302077T ES2065745T3 ES 2065745 T3 ES2065745 T3 ES 2065745T3 ES 92302077 T ES92302077 T ES 92302077T ES 92302077 T ES92302077 T ES 92302077T ES 2065745 T3 ES2065745 T3 ES 2065745T3
- Authority
- ES
- Spain
- Prior art keywords
- hydroxy
- 1alfa
- synthesis
- secosterol
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION SE REFIERE UN NUEVO METODO PARA LA PRODUCCION DE COMPUESTOS DE SECOSTEROL Y, EN PARTICULAR, A LA PREPARACION DE 1O-HIDROXI-HOMOPREGNACALCIFEROL QUE ES UN COMPUESTO DE SECOSTEROL EFICAZ PARA INDUCIR LA DIFERENCIACION DE CELULAS MALIGNAS Y POR TANTO ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO LA LEUCEMIA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/667,440 US5089641A (en) | 1991-03-11 | 1991-03-11 | Synthesis of 1α-hydroxy-secosterol compounds |
US83701092A | 1992-02-14 | 1992-02-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2065745T3 true ES2065745T3 (es) | 1995-02-16 |
Family
ID=27099682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92302077T Expired - Lifetime ES2065745T3 (es) | 1991-03-11 | 1992-03-11 | Sintesis de compuestos de 1alfa-hidroxi-secosterol. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0503923B1 (es) |
JP (1) | JP2793428B2 (es) |
AT (1) | ATE116292T1 (es) |
CA (1) | CA2062520C (es) |
DE (1) | DE69200980T2 (es) |
ES (1) | ES2065745T3 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
US5763234A (en) * | 1996-07-25 | 1998-06-09 | Florida Atlantic University | Secosteroids, and method for producing same |
MX2007006096A (es) * | 2004-11-22 | 2007-07-11 | Wisconsin Alumni Res Found | 2-metilen-19-nor-(20s)-1a-hidroxi-trishomopregnacalciferol. |
JP2008520708A (ja) | 2004-11-22 | 2008-06-19 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−19−ノル−(20R)−1α−ヒドロキシ−ビスホモプレグナカルシフェロール |
JP5036548B2 (ja) * | 2004-11-22 | 2012-09-26 | ウイスコンシン アラムニ リサーチ ファンデーション | 2−メチレン−19,21−ジノル−1α−ヒドロキシ−ビスホモプレグナカルシフェロール |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0078704B1 (en) * | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Intermediates in the synthesis of vitamin d derivatives |
AU575373B2 (en) * | 1984-02-08 | 1988-07-28 | F. Hoffmann-La Roche Ag | Calciferol derivatives |
EP0218714B1 (en) * | 1985-04-23 | 1991-08-07 | Wisconsin Alumni Research Foundation | Seco-sterol compounds effective in inducing the differentiation of malignant cells |
JP2642189B2 (ja) * | 1989-03-23 | 1997-08-20 | 株式会社クラレ | ステロイド誘導体及びその製造方法 |
EP0402982B1 (en) * | 1989-06-15 | 1994-01-05 | Duphar International Research B.V | Adduct-aldehyde and its use for the preparation of a vitamin-D compound |
GB8914963D0 (en) * | 1989-06-29 | 1989-08-23 | Leo Pharm Prod Ltd | Chemical compounds |
GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
-
1992
- 1992-03-09 CA CA002062520A patent/CA2062520C/en not_active Expired - Lifetime
- 1992-03-11 ES ES92302077T patent/ES2065745T3/es not_active Expired - Lifetime
- 1992-03-11 AT AT92302077T patent/ATE116292T1/de active
- 1992-03-11 DE DE69200980T patent/DE69200980T2/de not_active Expired - Lifetime
- 1992-03-11 EP EP92302077A patent/EP0503923B1/en not_active Expired - Lifetime
- 1992-03-11 JP JP4087659A patent/JP2793428B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2062520A1 (en) | 1992-09-12 |
JPH0597796A (ja) | 1993-04-20 |
CA2062520C (en) | 1998-08-11 |
EP0503923A1 (en) | 1992-09-16 |
DE69200980T2 (de) | 1995-05-11 |
DE69200980D1 (de) | 1995-02-09 |
ATE116292T1 (de) | 1995-01-15 |
JP2793428B2 (ja) | 1998-09-03 |
EP0503923B1 (en) | 1994-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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