ATE163179T1 - Vitamin-d3-analoge - Google Patents

Vitamin-d3-analoge

Info

Publication number
ATE163179T1
ATE163179T1 AT94117921T AT94117921T ATE163179T1 AT E163179 T1 ATE163179 T1 AT E163179T1 AT 94117921 T AT94117921 T AT 94117921T AT 94117921 T AT94117921 T AT 94117921T AT E163179 T1 ATE163179 T1 AT E163179T1
Authority
AT
Austria
Prior art keywords
agents
treatment
compounds
analogues
vitamin
Prior art date
Application number
AT94117921T
Other languages
English (en)
Inventor
Thomas I Doran
Bernard Michael Hennessy
John Arthur Mclane
Giacomo Pizzolato
Farhad Sedarati
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE163179T1 publication Critical patent/ATE163179T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT94117921T 1993-11-24 1994-11-14 Vitamin-d3-analoge ATE163179T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/158,068 US5428029A (en) 1993-11-24 1993-11-24 Vitamin D3 fluorinated analogs

Publications (1)

Publication Number Publication Date
ATE163179T1 true ATE163179T1 (de) 1998-02-15

Family

ID=22566563

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94117921T ATE163179T1 (de) 1993-11-24 1994-11-14 Vitamin-d3-analoge

Country Status (15)

Country Link
US (1) US5428029A (de)
EP (1) EP0654467B1 (de)
JP (1) JP2602633B2 (de)
CN (1) CN1049653C (de)
AT (1) ATE163179T1 (de)
AU (1) AU686251B2 (de)
CA (1) CA2135708C (de)
DE (1) DE69408516T2 (de)
DK (1) DK0654467T3 (de)
ES (1) ES2114116T3 (de)
GR (1) GR3026717T3 (de)
NZ (1) NZ264925A (de)
PH (1) PH31321A (de)
RU (1) RU2134260C1 (de)
ZA (1) ZA949149B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
CA2175881A1 (en) * 1995-05-09 1996-11-10 Andrzej Kutner Vitamin d compounds and methods of preparing these compounds
AU1429397A (en) * 1995-12-29 1997-07-28 A And D Assay, Incorporated Labeled vitamin d compounds and the use thereof
US5747479A (en) * 1996-01-03 1998-05-05 Hoffmann-La Roche Inc. Vitamin D3 analogs useful for reversing the photodamage in sun-exposed skin
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
KR100573234B1 (ko) * 1996-12-20 2006-04-24 쥬가이 세이야쿠 가부시키가이샤 16-엔-비타민 ｄ 유도체
US5843928A (en) * 1997-03-17 1998-12-01 Wisconsin Alumni Research Foundation 2-alkylidene-19-nor-vitamin D compounds
US6008209A (en) * 1997-04-28 1999-12-28 Hoffmann-La Roche Inc. Method of using vitamin D3 analogs with bis C-20 side chains
EP0884308B1 (de) * 1997-05-02 2003-04-16 Duphar International Research B.V Verfahren zur Herstellung von 16-Dehydro Vitamin D Verbindungen
EP0981514B1 (de) * 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
EP0981523B1 (de) * 1997-05-16 2005-12-07 Woman & Infants Hospital Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen
US5872113A (en) * 1997-05-16 1999-02-16 Syntex (U.S.A.) Inc. Fluorinated vitamin D3 analogs
US20020076442A1 (en) * 1997-09-02 2002-06-20 Martin Burke Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
DE69814109T2 (de) * 1997-09-08 2004-02-26 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
EP0957098A1 (de) * 1998-05-14 1999-11-17 F. Hoffmann-La Roche Ag Zwischenprodukte zur Synthese von 3-epi Vitamin D3 Metaboliten und Analogen
US6043386A (en) * 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3
AU3390400A (en) * 1999-03-05 2000-09-21 Johns Hopkins University, The Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US7122533B2 (en) * 1999-11-29 2006-10-17 The United States Of America As Represented By The Department Of Health And Human Services Cosalane compounds and methods for their use
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
DK1286962T3 (da) 2000-05-31 2008-10-06 Wisconsin Alumni Res Found 2-Ethyl og 2-ethyliden-19-nor-vitamin D-forbindelser
EP1392323B1 (de) * 2001-05-22 2008-10-08 Bioxell S.p.a. Verwendung eines analoges des vitamins d3 zur behandlung des autoimmunen diabetes
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
US20080260834A1 (en) * 2002-08-20 2008-10-23 Martin Burke Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
CA2510228C (en) * 2002-12-18 2012-10-30 Johns Hopkins University 25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3
KR20050120787A (ko) * 2003-04-10 2005-12-23 위스콘신 얼럼나이 리서어치 화운데이션 2-프로필리덴-19-노르-비타민 ｄ 화합물
PT103177A (pt) 2003-09-24 2005-03-31 Bioxell Spa 1-alfa-fluoro-25-hidroxi-16,23e-dieno-26,27-bis-homo-20-epi-colecalciferol, seus sais ou esteres e sua utilizacao no fabrico de medicamentos
US20080039434A1 (en) * 2004-03-01 2008-02-14 Bioxell S. P.A. Treatment of Interstitial Cystitis with Vitamin D Compounds
US20080293647A1 (en) 2004-11-12 2008-11-27 Luciano Adorini Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US8906888B2 (en) * 2005-04-25 2014-12-09 Cytochroma Inc. Low-calcemic 16,23-diene 25-oxime analogs of 1α,25-dihydroxy vitamin D3
NZ567438A (en) * 2005-09-22 2010-11-26 Wisconsin Alumni Res Found 19,23,24,25,26,27-Hexanor-1alpha-hydroxyvitamin D3
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
US8754067B2 (en) 2010-11-12 2014-06-17 Wisconsin Alumni Research Foundation 22-haloacetoxy-homopregnacalciferol analogs and their uses
JP6830599B2 (ja) * 2017-03-28 2021-02-17 関東電化工業株式会社 モノヒドロペルフルオロアルカンを出発原料としたペルフルオロアルキル化剤の新規製造法、及びそれらを用いた芳香族ペルフルオロアルキル化合物の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
JPH075542B2 (ja) * 1988-09-14 1995-01-25 呉羽化学工業株式会社 ビタミンｄ▲下３▼誘導体及びその製造方法
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs

Also Published As

Publication number Publication date
AU686251B2 (en) 1998-02-05
DK0654467T3 (da) 1998-09-23
RU94041201A (ru) 1996-10-10
JPH07188159A (ja) 1995-07-25
CN1108245A (zh) 1995-09-13
AU7890394A (en) 1995-06-01
EP0654467B1 (de) 1998-02-11
DE69408516T2 (de) 1998-07-02
EP0654467A3 (de) 1995-11-08
CN1049653C (zh) 2000-02-23
CA2135708C (en) 2006-01-03
JP2602633B2 (ja) 1997-04-23
PH31321A (en) 1998-07-06
EP0654467A2 (de) 1995-05-24
CA2135708A1 (en) 1995-05-25
RU2134260C1 (ru) 1999-08-10
GR3026717T3 (en) 1998-07-31
ZA949149B (en) 1995-05-24
DE69408516D1 (de) 1998-03-19
US5428029A (en) 1995-06-27
NZ264925A (en) 1996-05-28
ES2114116T3 (es) 1998-05-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee