ES2113585T3 - Derivados de fenilalcanolamina como antagonistas del receptor de nmda. - Google Patents
Derivados de fenilalcanolamina como antagonistas del receptor de nmda.Info
- Publication number
- ES2113585T3 ES2113585T3 ES94112867T ES94112867T ES2113585T3 ES 2113585 T3 ES2113585 T3 ES 2113585T3 ES 94112867 T ES94112867 T ES 94112867T ES 94112867 T ES94112867 T ES 94112867T ES 2113585 T3 ES2113585 T3 ES 2113585T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- antagonists
- nmda receptor
- hydroxy
- phenylalcanolamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title abstract 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 3
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
- Table Devices Or Equipment (AREA)
- Fats And Perfumes (AREA)
- Organic Insulating Materials (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11638593A | 1993-09-02 | 1993-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2113585T3 true ES2113585T3 (es) | 1998-05-01 |
Family
ID=22366865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94112867T Expired - Lifetime ES2113585T3 (es) | 1993-09-02 | 1994-08-18 | Derivados de fenilalcanolamina como antagonistas del receptor de nmda. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0648744B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2610784B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100360954B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1061035C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE162520T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU7149794A (cg-RX-API-DMAC7.html) |
| BR (1) | BR9403418A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2129771C (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ210694A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69408078T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0648744T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2113585T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI107607B (cg-RX-API-DMAC7.html) |
| GR (1) | GR3026622T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT70558A (cg-RX-API-DMAC7.html) |
| IL (1) | IL110812A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO943231L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ264320A (cg-RX-API-DMAC7.html) |
| PL (1) | PL304863A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU94031753A (cg-RX-API-DMAC7.html) |
| TW (1) | TW281670B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA946529B (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658909A (en) * | 1994-11-17 | 1997-08-19 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease |
| US6214994B1 (en) | 1997-04-21 | 2001-04-10 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1′-yl propanones |
| US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
| FR2742051B1 (fr) * | 1995-12-06 | 1998-02-06 | Synthelabo | Utilisation de composes ayant une affinite pour le site de liaison du (3h)ifenprodil pour la fabrication de medicaments utiles dans la prevention et le traitement des neuropathies |
| ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| BR9814867A (pt) | 1997-10-24 | 2000-10-03 | Warner Lambert Co | Método para tratar discinesias relacionadas a doenças ou induzidas por drogas |
| GB9804885D0 (en) | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| DE19812331A1 (de) * | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
| IL159393A (en) * | 2001-07-24 | 2011-01-31 | Richter Gedeon Vegyeszet | Piperidine derivatives, pharmaceutical compositions containing them, processes for their preparation and uses thereof |
| JP4737418B2 (ja) | 2003-09-25 | 2011-08-03 | 塩野義製薬株式会社 | Ｎｍｄａ受容体拮抗作用を有するピペリジン誘導体 |
| KR20140097132A (ko) | 2011-11-22 | 2014-08-06 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 허혈성 손상을 치료하기 위한 시스테아민 및/또는 시스타민 |
| RU2649406C1 (ru) * | 2017-09-21 | 2018-04-03 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | 3-n-замещенные борнилпропионаты, используемые в качестве ингибиторов вируса марбург |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4261285A (en) * | 1984-06-01 | 1985-12-05 | Tokyo Tanabe Company Limited | 1-propanone derivatives |
| DE3433036A1 (de) * | 1984-09-08 | 1986-03-20 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate und diese enthaltende fungizide sowie verfahren zur bekaempfung von pilzen |
| EP0398578B1 (en) * | 1989-05-17 | 1997-03-12 | Pfizer Inc. | 2-piperidino-1-alkanol derivatives as antiischemic agents |
| US4940789A (en) * | 1989-10-10 | 1990-07-10 | American Home Products Corporation | 10,11-dihydro-5-alkyl-12-substituted-10,5-(iminomethano)-5H-dibenzo[a,d]cycloheptenes as neuroprotectant agents |
| ATE154010T1 (de) * | 1990-10-15 | 1997-06-15 | Astra Ab | 2-phenyl- und 2-thienyl-(2)-piperidinderivate mit neuroprotektiven eigenschaften |
| SE9003652D0 (sv) * | 1990-11-15 | 1990-11-15 | Astra Ab | New heterocyclic compounds |
-
1994
- 1994-08-03 TW TW083107127A patent/TW281670B/zh active
- 1994-08-09 CA CA002129771A patent/CA2129771C/en not_active Expired - Fee Related
- 1994-08-18 DK DK94112867T patent/DK0648744T3/da active
- 1994-08-18 DE DE69408078T patent/DE69408078T2/de not_active Expired - Fee Related
- 1994-08-18 EP EP94112867A patent/EP0648744B1/en not_active Expired - Lifetime
- 1994-08-18 ES ES94112867T patent/ES2113585T3/es not_active Expired - Lifetime
- 1994-08-18 AT AT94112867T patent/ATE162520T1/de not_active IP Right Cessation
- 1994-08-26 ZA ZA946529A patent/ZA946529B/xx unknown
- 1994-08-26 NZ NZ264320A patent/NZ264320A/en unknown
- 1994-08-26 AU AU71497/94A patent/AU7149794A/en not_active Abandoned
- 1994-08-29 HU HU9402479A patent/HUT70558A/hu unknown
- 1994-08-29 IL IL11081294A patent/IL110812A0/xx unknown
- 1994-08-30 JP JP6205530A patent/JP2610784B2/ja not_active Expired - Fee Related
- 1994-09-01 RU RU94031753/04A patent/RU94031753A/ru unknown
- 1994-09-01 CN CN94115651A patent/CN1061035C/zh not_active Expired - Fee Related
- 1994-09-01 NO NO943231A patent/NO943231L/no unknown
- 1994-09-01 CZ CZ942106A patent/CZ210694A3/cs unknown
- 1994-09-01 KR KR1019940021962A patent/KR100360954B1/ko not_active Expired - Fee Related
- 1994-09-01 PL PL94304863A patent/PL304863A1/xx unknown
- 1994-09-01 BR BR9403418A patent/BR9403418A/pt not_active Application Discontinuation
- 1994-09-02 FI FI944044A patent/FI107607B/fi active
-
1998
- 1998-04-10 GR GR980400818T patent/GR3026622T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI107607B (fi) | 2001-09-14 |
| HU9402479D0 (en) | 1994-10-28 |
| HUT70558A (en) | 1995-10-30 |
| ATE162520T1 (de) | 1998-02-15 |
| TW281670B (cg-RX-API-DMAC7.html) | 1996-07-21 |
| ZA946529B (en) | 1995-03-02 |
| CN1061035C (zh) | 2001-01-24 |
| EP0648744B1 (en) | 1998-01-21 |
| KR950008481A (ko) | 1995-04-17 |
| NZ264320A (en) | 1996-02-27 |
| CN1105990A (zh) | 1995-08-02 |
| CA2129771A1 (en) | 1995-03-03 |
| EP0648744A1 (en) | 1995-04-19 |
| BR9403418A (pt) | 1996-09-03 |
| AU7149794A (en) | 1995-03-16 |
| KR100360954B1 (ko) | 2003-04-16 |
| NO943231D0 (no) | 1994-09-01 |
| PL304863A1 (en) | 1995-03-06 |
| DE69408078T2 (de) | 1998-07-09 |
| DE69408078D1 (de) | 1998-02-26 |
| NO943231L (no) | 1995-03-03 |
| FI944044L (fi) | 1995-03-03 |
| GR3026622T3 (en) | 1998-07-31 |
| JP2610784B2 (ja) | 1997-05-14 |
| IL110812A0 (en) | 1994-11-11 |
| DK0648744T3 (da) | 1998-09-21 |
| RU94031753A (ru) | 1996-07-20 |
| FI944044A0 (fi) | 1994-09-02 |
| CZ210694A3 (en) | 1995-08-16 |
| CA2129771C (en) | 2006-03-21 |
| JPH0782250A (ja) | 1995-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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