MX9306844A - Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye. - Google Patents

Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye.

Info

Publication number
MX9306844A
MX9306844A MX9306844A MX9306844A MX9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A
Authority
MX
Mexico
Prior art keywords
formula
compounds
membered
carbon
supreparation
Prior art date
Application number
MX9306844A
Other languages
English (en)
Inventor
Laramie Mary Gaster
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929223155A external-priority patent/GB9223155D0/en
Priority claimed from GB939309644A external-priority patent/GB9309644D0/en
Priority claimed from GB939315202A external-priority patent/GB9315202D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9306844A publication Critical patent/MX9306844A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

La invención describe los compuestos de la fórmula (I) y las salesfarmacéuticamente aceptables de estos, y el uso de los compuestos de lafórmula (I) o de las sales farmacéuticamente aceptables de éstos: en dondeX es un grupo aromático monocíclico o policíclico, Y es O o NH; Z es de lasubfórmula: en donde -(CH2)n1 está unido al carbono; y n1 es 0, 1, 3 ó 4;q es 0, 1, 2 ó 3; Ra es un alquileno de cadena lineal o ramificada cuyalongitud es de 1-6 átomos de carbono sustituidos en la parte terminal porR7, donde R7 es arilo, un cicloalquilo de 3 a 8 miembros, heterociclilo de3 a 8 miembros, un heteroarilo monocíclico de 5 ó 6 miembros o unheteroarilo bicíclico de 9 ó 10 miembros unido a través del carbono, o R7es un alcoxicarbonilo de C2-7 o un alquilo C1-6 hidroxi secundario oterciario sustituido; y R6 es hidrógeno o alquilo de C1-6; o un compuestode la fórmula (I) en donde el enlace CO-Y se sustituye por un bioisósteroheterocíclico; y su uso como un producto farmacéutico en el tratamiento delos desórdenes gastrointestinales, los desórdenes cardiovasculares y losdesórdenes en el SNC.
MX9306844A 1992-11-05 1993-11-03 Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye. MX9306844A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929223155A GB9223155D0 (en) 1992-11-05 1992-11-05 Pharmaceuticals
GB939309644A GB9309644D0 (en) 1993-05-11 1993-05-11 Pharmaceuticals
GB939315202A GB9315202D0 (en) 1993-07-22 1993-07-22 Pharmaceuticals

Publications (1)

Publication Number Publication Date
MX9306844A true MX9306844A (es) 1995-01-31

Family

ID=27266442

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306844A MX9306844A (es) 1992-11-05 1993-11-03 Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye.

Country Status (10)

Country Link
US (1) US5705498A (es)
EP (1) EP0667867A1 (es)
JP (1) JPH08502741A (es)
KR (1) KR950704328A (es)
CN (1) CN1092422A (es)
AU (1) AU680453B2 (es)
CA (1) CA2148700A1 (es)
MX (1) MX9306844A (es)
NZ (1) NZ257545A (es)
WO (1) WO1994010174A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5726187A (en) * 1992-10-16 1998-03-10 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
US6096761A (en) * 1996-02-15 2000-08-01 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
DE19613550A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Neue Pyrimido[1,2-a]indole
US6100397A (en) * 1996-08-16 2000-08-08 Smithkline Beecham Plc Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
TW548103B (en) 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
FR2781482B1 (fr) * 1998-07-27 2001-08-31 Adir Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2340952C (en) * 1998-09-10 2009-12-08 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
GB9820294D0 (en) * 1998-09-17 1998-11-11 Smithkline Beecham Plc Pharmaceuticals
TW570920B (en) 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US6552046B2 (en) * 2000-06-07 2003-04-22 Aryx Therapeutics Materials and methods for the treatment of gastroesophageal reflux disease
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
GEP20084527B (en) * 2003-09-03 2008-11-10 Pfizer Benzimidazolone compounds having 5-ht4 receptor agonistic activity
US8138204B2 (en) * 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
MXPA06007853A (es) 2004-01-07 2007-01-26 Aryx Therapeutics Compuestos estereoisomericos y metodos para el tratamiento de desordenes gastrointestinales y del sistema nervioso central.
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
MXPA06014486A (es) * 2004-06-15 2007-03-01 Pfizer Derivados de acido carboxilico de bencimidazolona.
EP1856110B1 (en) * 2005-02-22 2011-06-22 Pfizer Inc. Oxyindole derivatives as 5ht4 receptor agonists
US7326787B2 (en) * 2005-08-31 2008-02-05 Aryx Therapeutics, Inc. Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
WO2007149929A1 (en) * 2006-06-23 2007-12-27 Aryx Therapeutics, Inc. Piperidine derivatives for the treatment of gastrointestinal and cns disorders
US9611249B2 (en) 2012-02-12 2017-04-04 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
SI2817301T1 (sl) 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A Uporaba 1H-indazol-3-karboksamidnih spojin kot inhibitorjev glikogen sintaza-kinaze-3beta
CN103420989B (zh) * 2012-05-15 2016-03-23 华中科技大学 苯并二噁烷类衍生物及其应用
IN2013CH01199A (es) 2013-03-20 2015-08-14 Suven Life Sciences Ltd
CA2932428C (en) 2013-12-16 2017-10-24 Suven Life Sciences Limited Indazole compounds as 5-ht4 receptor agonists
KR20210005863A (ko) 2018-05-07 2021-01-15 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사마이드 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8503055D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Piperonylcarboxamido derivatives
ATE137501T1 (de) * 1989-07-03 1996-05-15 Yoshitomi Pharmaceutical Benzazin-verbindungen und deren pharmazeutische verwendungen
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
ATE182591T1 (de) * 1991-09-12 1999-08-15 Smithkline Beecham Plc 5-ht4 rezeptor antagonisten
EP0630376B1 (en) * 1992-03-12 1999-06-02 Smithkline Beecham Plc Condensed indole derivatives as 5-ht4-receptor antagonists

Also Published As

Publication number Publication date
JPH08502741A (ja) 1996-03-26
EP0667867A1 (en) 1995-08-23
US5705498A (en) 1998-01-06
NZ257545A (en) 1997-01-29
CN1092422A (zh) 1994-09-21
AU5419794A (en) 1994-05-24
CA2148700A1 (en) 1994-05-11
KR950704328A (ko) 1995-11-17
WO1994010174A1 (en) 1994-05-11
AU680453B2 (en) 1997-07-31

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