MX9306844A - Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye. - Google Patents
Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye.Info
- Publication number
- MX9306844A MX9306844A MX9306844A MX9306844A MX9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A MX 9306844 A MX9306844 A MX 9306844A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compounds
- membered
- carbon
- supreparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención describe los compuestos de la fórmula (I) y las salesfarmacéuticamente aceptables de estos, y el uso de los compuestos de lafórmula (I) o de las sales farmacéuticamente aceptables de éstos: en dondeX es un grupo aromático monocíclico o policíclico, Y es O o NH; Z es de lasubfórmula: en donde -(CH2)n1 está unido al carbono; y n1 es 0, 1, 3 ó 4;q es 0, 1, 2 ó 3; Ra es un alquileno de cadena lineal o ramificada cuyalongitud es de 1-6 átomos de carbono sustituidos en la parte terminal porR7, donde R7 es arilo, un cicloalquilo de 3 a 8 miembros, heterociclilo de3 a 8 miembros, un heteroarilo monocíclico de 5 ó 6 miembros o unheteroarilo bicíclico de 9 ó 10 miembros unido a través del carbono, o R7es un alcoxicarbonilo de C2-7 o un alquilo C1-6 hidroxi secundario oterciario sustituido; y R6 es hidrógeno o alquilo de C1-6; o un compuestode la fórmula (I) en donde el enlace CO-Y se sustituye por un bioisósteroheterocíclico; y su uso como un producto farmacéutico en el tratamiento delos desórdenes gastrointestinales, los desórdenes cardiovasculares y losdesórdenes en el SNC.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929223155A GB9223155D0 (en) | 1992-11-05 | 1992-11-05 | Pharmaceuticals |
| GB939309644A GB9309644D0 (en) | 1993-05-11 | 1993-05-11 | Pharmaceuticals |
| GB939315202A GB9315202D0 (en) | 1993-07-22 | 1993-07-22 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9306844A true MX9306844A (es) | 1995-01-31 |
Family
ID=27266442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9306844A MX9306844A (es) | 1992-11-05 | 1993-11-03 | Compuestos novedosos que tienen actividad farmacologica, proceso para supreparacion y composicion farmaceutica que los incluye. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5705498A (es) |
| EP (1) | EP0667867A1 (es) |
| JP (1) | JPH08502741A (es) |
| KR (1) | KR950704328A (es) |
| CN (1) | CN1092422A (es) |
| AU (1) | AU680453B2 (es) |
| CA (1) | CA2148700A1 (es) |
| MX (1) | MX9306844A (es) |
| NZ (1) | NZ257545A (es) |
| WO (1) | WO1994010174A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5726187A (en) * | 1992-10-16 | 1998-03-10 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists |
| GB9312348D0 (en) * | 1993-06-16 | 1993-07-28 | Smithkline Beecham Plc | Pharmaceuticals |
| TW360653B (en) * | 1995-03-01 | 1999-06-11 | Janssen Pharmaceutica Nv | A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition |
| US6096761A (en) * | 1996-02-15 | 2000-08-01 | Janssen Pharmaceutica N.V. | Esters of 3-hydroxy-piperidinemethanol derivatives |
| NZ330263A (en) * | 1996-02-15 | 1999-06-29 | Janssen Pharmaceutica Nv | Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying |
| TW445263B (en) * | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
| DE19613550A1 (de) * | 1996-04-04 | 1997-10-09 | Bayer Ag | Neue Pyrimido[1,2-a]indole |
| US6100397A (en) * | 1996-08-16 | 2000-08-08 | Smithkline Beecham Plc | Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process |
| TW548103B (en) | 1997-07-11 | 2003-08-21 | Janssen Pharmaceutica Nv | Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| FR2781482B1 (fr) * | 1998-07-27 | 2001-08-31 | Adir | Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2340952C (en) * | 1998-09-10 | 2009-12-08 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists |
| GB9820294D0 (en) * | 1998-09-17 | 1998-11-11 | Smithkline Beecham Plc | Pharmaceuticals |
| TW570920B (en) | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| AU2001275326C1 (en) * | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| GB0211230D0 (en) | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| ATE539077T1 (de) | 2003-09-03 | 2012-01-15 | Pfizer | Benzimidazolonverbindungen mit agonistischer wirkung am 5-ht4 rezeptor |
| WO2005068461A1 (en) | 2004-01-07 | 2005-07-28 | Aryx Therapeutics | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| US8138204B2 (en) * | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| BRPI0512046A (pt) * | 2004-06-15 | 2008-02-06 | Pfizer | derivados de ácido benzimidazolona carboxìlico |
| US7737163B2 (en) | 2004-06-15 | 2010-06-15 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| NZ556627A (en) * | 2005-02-22 | 2010-09-30 | Pfizer | Oxyindole derivatives as 5HT4 receptor agonists |
| CA2620379C (en) * | 2005-08-31 | 2015-02-24 | Aryx Therapeutics, Inc. | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders |
| US20080085915A1 (en) * | 2006-06-23 | 2008-04-10 | Cyrus Becker | Compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| WO2013124158A1 (en) | 2012-02-21 | 2013-08-29 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| PT2817301E (pt) | 2012-02-21 | 2016-03-14 | Aziende Chimiche Riunite Angelini Francesco - A C R A F - S P A | Utlização de compostos de 1h-indazolo-3-carboxamida como inibidores da cinase 3 beta da sintase do glicogénio |
| CN103420989B (zh) * | 2012-05-15 | 2016-03-23 | 华中科技大学 | 苯并二噁烷类衍生物及其应用 |
| DK2976337T3 (en) | 2013-03-20 | 2018-07-16 | Suven Life Sciences Ltd | 5-amino-quinoline-8-carboxamide derivatives as 5-HT4 receptor agonists |
| BR112016013974B1 (pt) | 2013-12-16 | 2022-11-22 | Suven Life Sciences Limited | Composto, composição farmacêutica, uso da composição farmacêutica e uso do composto |
| MA52557A (fr) | 2018-05-07 | 2021-03-17 | Acraf | Composés de 1h-indazole-3-carboxamide utilisés en tant qu'inhibiteurs de la glycogène synthase kinase 3 bêta |
| TW202506104A (zh) | 2023-07-02 | 2025-02-16 | 美商英格瑞治療公司 | 氘化有機化合物及其用途（一） |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8503055D0 (sv) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | Piperonylcarboxamido derivatives |
| CA2020315A1 (en) * | 1989-07-03 | 1991-01-04 | Takeshi Kawakita | Benzazine compounds and pharmaceutical uses thereof |
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| AU2435092A (en) * | 1991-08-20 | 1993-03-16 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| FI941178L (fi) * | 1991-09-12 | 1994-03-11 | Smithkline Beecham Plc | 5-HT4-reseptoriantagonisteja |
| CA2131797C (en) * | 1992-03-12 | 2010-05-18 | Laramie Mary Gaster | Condensed indole derivatives as 5ht4-receptor antagonists |
-
1993
- 1993-11-02 WO PCT/EP1993/003054 patent/WO1994010174A1/en not_active Ceased
- 1993-11-02 CA CA002148700A patent/CA2148700A1/en not_active Abandoned
- 1993-11-02 NZ NZ257545A patent/NZ257545A/en unknown
- 1993-11-02 US US08/433,369 patent/US5705498A/en not_active Expired - Fee Related
- 1993-11-02 EP EP93924569A patent/EP0667867A1/en not_active Withdrawn
- 1993-11-02 KR KR1019950701784A patent/KR950704328A/ko not_active Ceased
- 1993-11-02 AU AU54197/94A patent/AU680453B2/en not_active Ceased
- 1993-11-02 JP JP6510716A patent/JPH08502741A/ja active Pending
- 1993-11-03 MX MX9306844A patent/MX9306844A/es unknown
- 1993-11-04 CN CN93112680A patent/CN1092422A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ257545A (en) | 1997-01-29 |
| US5705498A (en) | 1998-01-06 |
| JPH08502741A (ja) | 1996-03-26 |
| CA2148700A1 (en) | 1994-05-11 |
| EP0667867A1 (en) | 1995-08-23 |
| KR950704328A (ko) | 1995-11-17 |
| CN1092422A (zh) | 1994-09-21 |
| AU5419794A (en) | 1994-05-24 |
| AU680453B2 (en) | 1997-07-31 |
| WO1994010174A1 (en) | 1994-05-11 |
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