MX9205816A - Acidos benzimidazolfosfono-amino y proceso para su preparacion. - Google Patents

Acidos benzimidazolfosfono-amino y proceso para su preparacion.

Info

Publication number
MX9205816A
MX9205816A MX9205816A MX9205816A MX9205816A MX 9205816 A MX9205816 A MX 9205816A MX 9205816 A MX9205816 A MX 9205816A MX 9205816 A MX9205816 A MX 9205816A MX 9205816 A MX9205816 A MX 9205816A
Authority
MX
Mexico
Prior art keywords
amino acids
hydrogen
compounds
lower alkyl
benzimidazolfosfono
Prior art date
Application number
MX9205816A
Other languages
English (en)
Inventor
Reinhardt Bernhard Baudy
Horace Fletcher Iii
John Patrick Yardley
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9205816A publication Critical patent/MX9205816A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se relaciona con compuestos de fórmula (I) en donde: R es hidrógeno, alquilo inferior, benzilo o pivaloiloximetilo; R1 y R2 son independientemente, hidrógeno, alquilo inferior, alcoxi inferior, trifluorometilo, trifluorometoxi, metansulfonilamino, acetilamino, o halo, o cuando se toman juntos R1 y R2 representan un grupo metilendioxi, y las sales farmacológicamente aceptables de los mismos son antagonistas del NMDA útil en el tratamiento y prevención de condiciones patológicas relacionadas con el sistema nervioso central resultantes de la sobre estimulación por aminoácidos excitadores.
MX9205816A 1991-10-11 1992-10-09 Acidos benzimidazolfosfono-amino y proceso para su preparacion. MX9205816A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/776,528 US5124319A (en) 1991-10-11 1991-10-11 Benzimidazole phosphono-amino acids

Publications (1)

Publication Number Publication Date
MX9205816A true MX9205816A (es) 1993-07-01

Family

ID=25107643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205816A MX9205816A (es) 1991-10-11 1992-10-09 Acidos benzimidazolfosfono-amino y proceso para su preparacion.

Country Status (22)

Country Link
US (1) US5124319A (es)
EP (1) EP0539057B1 (es)
JP (1) JPH05222077A (es)
KR (1) KR930007961A (es)
AT (1) ATE155473T1 (es)
AU (1) AU656811B2 (es)
CA (1) CA2080253A1 (es)
CZ (1) CZ308392A3 (es)
DE (1) DE69220879T2 (es)
DK (1) DK0539057T3 (es)
ES (1) ES2104841T3 (es)
FI (1) FI924570A (es)
GR (1) GR3024767T3 (es)
HU (2) HUT62196A (es)
IL (1) IL103330A (es)
MX (1) MX9205816A (es)
NO (1) NO300690B1 (es)
NZ (1) NZ244587A (es)
RU (1) RU2073004C1 (es)
SG (1) SG47768A1 (es)
SK (1) SK279381B6 (es)
ZA (1) ZA927535B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334618A (en) * 1991-04-04 1994-08-02 The Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
IS4233A (is) * 1993-12-22 1995-06-23 Astra Aktiebolag Misleit hringtengd efnasambönd
US5864040A (en) * 1996-01-11 1999-01-26 American Home Products Corporation Benzimidazole phosphono-amino acids
ATE253073T1 (de) * 1997-03-07 2003-11-15 Metabasis Therapeutics Inc Neue benzimidazol inhibitoren der fructose-1,6- bisphosphatase
US6284748B1 (en) * 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
GB9917822D0 (en) * 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6316474B1 (en) * 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
CA2521394A1 (en) * 2003-04-09 2004-10-28 Wyeth Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof
BRPI0409255A (pt) * 2003-04-09 2006-03-28 Wyeth Corp derivados de ácido 2-(8,9-dioxo-2,6-diazabi-ciclo(5.2.0)non-1(7)-en-2-il)alquil fosfÈnico e seu uso como antagonistas de receptores de d-asparto de -n-metila (nmda)
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
GT200400213A (es) * 2003-10-22 2007-09-05 Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo
CA2693032A1 (en) * 2007-06-29 2009-01-08 Emory University Nmda receptor antagonists for neuroprotection
BRPI0815821A2 (pt) * 2007-08-27 2015-02-18 Wyeth Llc Composições e métodos que empregam antagonistas nmda para alcançar um efeito poupador de anestésico.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU959724A1 (ru) * 1981-05-06 1982-09-23 Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт Способ регулировани роста растений огурца
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids

Also Published As

Publication number Publication date
SK279381B6 (sk) 1998-10-07
RU2073004C1 (ru) 1997-02-10
US5124319A (en) 1992-06-23
IL103330A (en) 1996-10-31
CA2080253A1 (en) 1993-04-12
IL103330A0 (en) 1993-03-15
HU9203203D0 (en) 1992-12-28
ZA927535B (en) 1994-03-30
FI924570A (fi) 1993-04-12
NO923940D0 (no) 1992-10-09
JPH05222077A (ja) 1993-08-31
AU656811B2 (en) 1995-02-16
DE69220879D1 (de) 1997-08-21
AU2626992A (en) 1993-04-22
EP0539057B1 (en) 1997-07-16
SK308392A3 (en) 1995-02-08
HUT62196A (en) 1993-04-28
NO300690B1 (no) 1997-07-07
CZ308392A3 (en) 1993-08-11
ES2104841T3 (es) 1997-10-16
GR3024767T3 (en) 1997-12-31
ATE155473T1 (de) 1997-08-15
KR930007961A (ko) 1993-05-20
DE69220879T2 (de) 1997-11-20
HU211942A9 (en) 1996-01-29
EP0539057A1 (en) 1993-04-28
DK0539057T3 (da) 1998-02-09
NZ244587A (en) 1994-04-27
NO923940L (no) 1993-04-13
SG47768A1 (en) 1998-04-17
FI924570A0 (fi) 1992-10-09

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees