GT200400213A - Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo - Google Patents
Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismoInfo
- Publication number
- GT200400213A GT200400213A GT200400213A GT200400213A GT200400213A GT 200400213 A GT200400213 A GT 200400213A GT 200400213 A GT200400213 A GT 200400213A GT 200400213 A GT200400213 A GT 200400213A GT 200400213 A GT200400213 A GT 200400213A
- Authority
- GT
- Guatemala
- Prior art keywords
- biciclo
- esteres
- etil
- phosphone
- diaza
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE AL COMPUESTO QUE SE MUESTRA EN EL RESUMEN EN EL QUE R1,R2,SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR NMDA POR LO QUE SON DE UTILIDAD EN PATOLOGIAS DEL SISTEMA NERVIOSO TALES COMO EPILEPSIA Y DESORDENES NEURODEGENERATIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51361103P | 2003-10-22 | 2003-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200400213A true GT200400213A (es) | 2007-09-05 |
Family
ID=34520119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200400213A GT200400213A (es) | 2003-10-22 | 2004-10-19 | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7345032B2 (es) |
| EP (1) | EP1675863A2 (es) |
| JP (1) | JP2007509857A (es) |
| KR (1) | KR20060094967A (es) |
| CN (1) | CN1871246A (es) |
| AR (1) | AR046130A1 (es) |
| AU (1) | AU2004284066A1 (es) |
| BR (1) | BRPI0415857A (es) |
| CA (1) | CA2543008A1 (es) |
| CO (1) | CO5690562A2 (es) |
| GT (1) | GT200400213A (es) |
| MX (1) | MXPA06004397A (es) |
| PA (1) | PA8615401A1 (es) |
| PE (1) | PE20050908A1 (es) |
| TW (1) | TW200514775A (es) |
| WO (1) | WO2005040176A2 (es) |
| ZA (1) | ZA200603236B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0409088A (pt) * | 2003-04-09 | 2006-04-11 | Wyeth Corp | composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos |
| CN102356087A (zh) * | 2009-03-19 | 2012-02-15 | 惠氏有限责任公司 | [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CN110996948A (zh) | 2017-06-12 | 2020-04-10 | 格莱泰施有限责任公司 | 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518660A1 (de) | 1965-07-09 | 1969-08-14 | Huels Chemische Werke Ag | Verfahren zur Herstellung aminosubstituierter Dioxocyclobutene |
| DE2428691A1 (de) * | 1974-06-14 | 1976-01-08 | Merck Patent Gmbh | Hexahydro-diazepino-indolderivate und verfahren zu ihrer herstellung |
| US4390701A (en) | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| CA1248531A (en) | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US5212291A (en) | 1986-10-23 | 1993-05-18 | American Cyanamid Company | Anthracycline derivatives as solubilized pro-drugs |
| JPH02184673A (ja) * | 1989-01-11 | 1990-07-19 | Yoshitomi Pharmaceut Ind Ltd | スルホンアミド化合物 |
| US5236695A (en) | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| ES2072015T3 (es) | 1990-08-21 | 1995-07-01 | Upjohn Co | Derivados del acido bisfosfonico como agente anti-artritico. |
| US5168103A (en) | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| US5124319A (en) | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| US5708152A (en) | 1992-03-27 | 1998-01-13 | Ciba Specialty Chemicals Corporation | N-substituted chitosan derivatives in a process for their preparation |
| DK124393D0 (da) | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
| US5583123A (en) | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
| TW427904B (en) | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
| UA52698C2 (uk) | 1996-10-04 | 2003-01-15 | Х. Луннбек А/С | Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі |
| US5990307A (en) * | 1997-08-01 | 1999-11-23 | American Home Products Corporation | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid |
| EP1000072B1 (en) | 1997-08-01 | 2003-02-19 | Wyeth | Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo [5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA78529C2 (en) | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20040082543A1 (en) | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
| PL1611144T3 (pl) | 2003-04-09 | 2011-03-31 | Wyeth Llc | Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA) |
| BRPI0409088A (pt) | 2003-04-09 | 2006-04-11 | Wyeth Corp | composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos |
| US20050142192A1 (en) | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
| JP2008515904A (ja) | 2004-10-08 | 2008-05-15 | ワイス | ［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノン−１（７）−エン−２−イル）アルキル］ホスホン酸の誘導体およびその製造方法 |
-
2004
- 2004-10-19 TW TW093131618A patent/TW200514775A/zh unknown
- 2004-10-19 GT GT200400213A patent/GT200400213A/es unknown
- 2004-10-20 PE PE2004001009A patent/PE20050908A1/es not_active Application Discontinuation
- 2004-10-20 CA CA002543008A patent/CA2543008A1/en not_active Abandoned
- 2004-10-20 CN CNA2004800312347A patent/CN1871246A/zh active Pending
- 2004-10-20 KR KR1020067007707A patent/KR20060094967A/ko not_active Application Discontinuation
- 2004-10-20 US US10/969,715 patent/US7345032B2/en not_active Expired - Fee Related
- 2004-10-20 BR BRPI0415857-1A patent/BRPI0415857A/pt not_active IP Right Cessation
- 2004-10-20 AR ARP040103799A patent/AR046130A1/es not_active Application Discontinuation
- 2004-10-20 JP JP2006536777A patent/JP2007509857A/ja active Pending
- 2004-10-20 WO PCT/US2004/034831 patent/WO2005040176A2/en active Application Filing
- 2004-10-20 AU AU2004284066A patent/AU2004284066A1/en not_active Abandoned
- 2004-10-20 EP EP04809997A patent/EP1675863A2/en not_active Withdrawn
- 2004-10-20 PA PA20048615401A patent/PA8615401A1/es unknown
- 2004-10-20 MX MXPA06004397A patent/MXPA06004397A/es active IP Right Grant
-
2006
- 2006-04-20 CO CO06037264A patent/CO5690562A2/es not_active Application Discontinuation
- 2006-04-21 ZA ZA200603236A patent/ZA200603236B/xx unknown
-
2008
- 2008-01-18 US US12/016,491 patent/US20080114165A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1871246A (zh) | 2006-11-29 |
| AR046130A1 (es) | 2005-11-23 |
| BRPI0415857A (pt) | 2007-01-09 |
| WO2005040176A2 (en) | 2005-05-06 |
| EP1675863A2 (en) | 2006-07-05 |
| PE20050908A1 (es) | 2005-12-02 |
| AU2004284066A1 (en) | 2005-05-06 |
| US20080114165A1 (en) | 2008-05-15 |
| US20050090470A1 (en) | 2005-04-28 |
| ZA200603236B (en) | 2009-09-30 |
| MXPA06004397A (es) | 2006-06-14 |
| US7345032B2 (en) | 2008-03-18 |
| TW200514775A (en) | 2005-05-01 |
| WO2005040176A3 (en) | 2005-12-01 |
| CA2543008A1 (en) | 2005-05-06 |
| JP2007509857A (ja) | 2007-04-19 |
| PA8615401A1 (es) | 2005-11-25 |
| KR20060094967A (ko) | 2006-08-30 |
| CO5690562A2 (es) | 2006-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GT200300014A (es) | Compuestos de espiropiperidina n-sustituidos como ligandos para el receptor orl-1 | |
| GT200600128A (es) | Derivados de ciclopentapiridina y tetrahidroquinolina | |
| GT200500124A (es) | (4-metoxi-7-morfolin-4-il-benzotiazol-2-il) amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico | |
| GT200600030A (es) | 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2 | |
| GT200500008A (es) | Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos | |
| TW200732321A (en) | Fast dissociating dopamine 2 receptor antagonists | |
| ECSP11011019A (es) | Antagonistas del receptor de orexina de isonicotinamida | |
| EA200800430A1 (ru) | Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов | |
| ECSP099374A (es) | Antagonistas de receptor de orexina de diazepan sustituido | |
| CL2009000734A1 (es) | Compuestos derivados de 4-aminociclohexano sustituido; composicion farmaceutica que comprende a dichos compuestos; y su uso como moduladores del receptor de opioides u y el receptor orl-1 en el tratamiento de la ansiedad, estres, depresion, epilepsia y alzheimer. | |
| WO2008148801A8 (en) | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission | |
| GT200600255A (es) | Antagonistas y agonistas de piperazin-piperidina del receptor 5-ht1a | |
| GT200200269A (es) | Derivados de 7-amino-benzotiazol | |
| GT200600422A (es) | Derivados de carboxamida como antagonistas del receptor muscarinico | |
| UY30910A1 (es) | Antagonistas del receptor de dopamina 2 de rapida disociacion | |
| CO6351782A2 (es) | COMPUESTOS NOVEDOSOS CON ACTIVIDAD ANTAGONISTA DEL RECEPTOR á 7 NICOTINICO DE ACETILCOLINA | |
| ECSP067091A (es) | Procesos para preparacion de antagonistas de receptor de hormona que libera gonadotropina | |
| TW200642690A (en) | Composition for treating central nervous system disorders | |
| CL2012001031A1 (es) | Compuestos derivados de 2-oxo-1-pirrolidinil-imidazotiadiazol; composición farmacéutica que los comprende; útiles para el tratamiento de la epilepsia, transtornos neurológicos, entre otros. | |
| CY1113820T1 (el) | Παραγωγα 4-αλκοξυπυριδαζινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2 | |
| IL208279A0 (en) | Spiro (5,5,) undecane derivatives | |
| GT200400041A (es) | Derivados azabiciclicos de piridiloximetilo y bencisoxazol | |
| GT200300234A (es) | Derivados terapeuticos de prolina | |
| GT200400117A (es) | Derivados de imidazol | |
| GT200400213A (es) | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo |