AR046130A1 - Metodos para la preparacion del acido (2-(8,9)- dioxo.2,6- diaza- biciclo ( 5.2.0) - non-1(7) - en -2-il) etil) fosfonico y esteres del mismo - Google Patents
Metodos para la preparacion del acido (2-(8,9)- dioxo.2,6- diaza- biciclo ( 5.2.0) - non-1(7) - en -2-il) etil) fosfonico y esteres del mismoInfo
- Publication number
- AR046130A1 AR046130A1 ARP040103799A ARP040103799A AR046130A1 AR 046130 A1 AR046130 A1 AR 046130A1 AR P040103799 A ARP040103799 A AR P040103799A AR P040103799 A ARP040103799 A AR P040103799A AR 046130 A1 AR046130 A1 AR 046130A1
- Authority
- AR
- Argentina
- Prior art keywords
- biciclo
- etil
- phosphone
- diaza
- dioxo
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 102100021090 Homeobox protein Hox-A9 Human genes 0.000 abstract 1
- 101001083156 Homo sapiens Homeobox protein Hox-A1 Proteins 0.000 abstract 1
- 101001083164 Homo sapiens Homeobox protein Hox-A10 Proteins 0.000 abstract 1
- 101001083158 Homo sapiens Homeobox protein Hox-A11 Proteins 0.000 abstract 1
- 101001083162 Homo sapiens Homeobox protein Hox-A13 Proteins 0.000 abstract 1
- 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 abstract 1
- 101001077578 Homo sapiens Homeobox protein Hox-A4 Proteins 0.000 abstract 1
- 101001077568 Homo sapiens Homeobox protein Hox-A5 Proteins 0.000 abstract 1
- 101001045083 Homo sapiens Homeobox protein Hox-A6 Proteins 0.000 abstract 1
- 101001045116 Homo sapiens Homeobox protein Hox-A7 Proteins 0.000 abstract 1
- 101001041174 Homo sapiens Homeobox protein Hox-A9 Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un procedimiento para preparar un compuesto de la fórmula (1), en donde R1 y R2 son independientemente alquilo C1-6 o haloalquilo C1-6; caracterizado porque comprende la etapa de hacer reaccionar, en un solvente, un compuesto de la fórmula (2), con un compuesto de la fórmula (3), en donde: Q1 y Q2 son cada uno independientemente OH, halógeno, o OX1, en donde X1 es alquilo C1-6, haloalquilo C1-6 o arilo; y dicho solvente tiene la fórmula HOX1; durante un tiempo y bajo condiciones efectivas para producir dicho compuesto de la fórmula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51361103P | 2003-10-22 | 2003-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046130A1 true AR046130A1 (es) | 2005-11-23 |
Family
ID=34520119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103799A AR046130A1 (es) | 2003-10-22 | 2004-10-20 | Metodos para la preparacion del acido (2-(8,9)- dioxo.2,6- diaza- biciclo ( 5.2.0) - non-1(7) - en -2-il) etil) fosfonico y esteres del mismo |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7345032B2 (es) |
| EP (1) | EP1675863A2 (es) |
| JP (1) | JP2007509857A (es) |
| KR (1) | KR20060094967A (es) |
| CN (1) | CN1871246A (es) |
| AR (1) | AR046130A1 (es) |
| AU (1) | AU2004284066A1 (es) |
| BR (1) | BRPI0415857A (es) |
| CA (1) | CA2543008A1 (es) |
| CO (1) | CO5690562A2 (es) |
| GT (1) | GT200400213A (es) |
| MX (1) | MXPA06004397A (es) |
| PA (1) | PA8615401A1 (es) |
| PE (1) | PE20050908A1 (es) |
| TW (1) | TW200514775A (es) |
| WO (1) | WO2005040176A2 (es) |
| ZA (1) | ZA200603236B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05010763A (es) * | 2003-04-09 | 2005-12-12 | Wyeth Corp | Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo. |
| CN102356087A (zh) | 2009-03-19 | 2012-02-15 | 惠氏有限责任公司 | [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CA3067162A1 (en) | 2017-06-12 | 2018-12-20 | Glytech Llc. | Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518660A1 (de) | 1965-07-09 | 1969-08-14 | Huels Chemische Werke Ag | Verfahren zur Herstellung aminosubstituierter Dioxocyclobutene |
| DE2428691A1 (de) * | 1974-06-14 | 1976-01-08 | Merck Patent Gmbh | Hexahydro-diazepino-indolderivate und verfahren zu ihrer herstellung |
| US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US5212291A (en) * | 1986-10-23 | 1993-05-18 | American Cyanamid Company | Anthracycline derivatives as solubilized pro-drugs |
| JPH02184673A (ja) * | 1989-01-11 | 1990-07-19 | Yoshitomi Pharmaceut Ind Ltd | スルホンアミド化合物 |
| US5236695A (en) * | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| EP0544812B1 (en) * | 1990-08-21 | 1995-04-05 | The Upjohn Company | Bisphosphonic acid derivatives as anti-arthritic agents |
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| US5708152A (en) * | 1992-03-27 | 1998-01-13 | Ciba Specialty Chemicals Corporation | N-substituted chitosan derivatives in a process for their preparation |
| DK124393D0 (da) | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
| US5583123A (en) * | 1994-12-22 | 1996-12-10 | Ciba-Geigy Corporation | Certain tetrazole derivatives |
| TW427904B (en) | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
| UA52698C2 (uk) | 1996-10-04 | 2003-01-15 | Х. Луннбек А/С | Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі |
| CA2297411C (en) | 1997-08-01 | 2008-12-02 | American Home Products Corporation | Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo [5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid |
| US5990307A (en) * | 1997-08-01 | 1999-11-23 | American Home Products Corporation | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20040082543A1 (en) * | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
| MXPA05010763A (es) | 2003-04-09 | 2005-12-12 | Wyeth Corp | Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo. |
| AU2004230895B2 (en) | 2003-04-09 | 2010-09-09 | Wyeth | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as N-methyl-D-aspartate (NMDA) receptor antagonists |
| US20050142192A1 (en) | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
| DE602005017915D1 (de) | 2004-10-08 | 2010-01-07 | Wyeth Corp | Derivate von ä2-(8,9-dioxo-2,6-diazabicycloä5.2.0ünon-1(7)-en-2-yl)alkylüphosphonsäure und verfahren zu deren herstellung |
-
2004
- 2004-10-19 GT GT200400213A patent/GT200400213A/es unknown
- 2004-10-19 TW TW093131618A patent/TW200514775A/zh unknown
- 2004-10-20 KR KR1020067007707A patent/KR20060094967A/ko not_active Application Discontinuation
- 2004-10-20 JP JP2006536777A patent/JP2007509857A/ja active Pending
- 2004-10-20 EP EP04809997A patent/EP1675863A2/en not_active Withdrawn
- 2004-10-20 MX MXPA06004397A patent/MXPA06004397A/es active IP Right Grant
- 2004-10-20 CN CNA2004800312347A patent/CN1871246A/zh active Pending
- 2004-10-20 WO PCT/US2004/034831 patent/WO2005040176A2/en active Application Filing
- 2004-10-20 AU AU2004284066A patent/AU2004284066A1/en not_active Abandoned
- 2004-10-20 CA CA002543008A patent/CA2543008A1/en not_active Abandoned
- 2004-10-20 PE PE2004001009A patent/PE20050908A1/es not_active Application Discontinuation
- 2004-10-20 BR BRPI0415857-1A patent/BRPI0415857A/pt not_active IP Right Cessation
- 2004-10-20 US US10/969,715 patent/US7345032B2/en not_active Expired - Fee Related
- 2004-10-20 AR ARP040103799A patent/AR046130A1/es not_active Application Discontinuation
- 2004-10-20 PA PA20048615401A patent/PA8615401A1/es unknown
-
2006
- 2006-04-20 CO CO06037264A patent/CO5690562A2/es not_active Application Discontinuation
- 2006-04-21 ZA ZA200603236A patent/ZA200603236B/xx unknown
-
2008
- 2008-01-18 US US12/016,491 patent/US20080114165A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7345032B2 (en) | 2008-03-18 |
| JP2007509857A (ja) | 2007-04-19 |
| WO2005040176A2 (en) | 2005-05-06 |
| US20050090470A1 (en) | 2005-04-28 |
| ZA200603236B (en) | 2009-09-30 |
| AU2004284066A1 (en) | 2005-05-06 |
| CA2543008A1 (en) | 2005-05-06 |
| KR20060094967A (ko) | 2006-08-30 |
| EP1675863A2 (en) | 2006-07-05 |
| US20080114165A1 (en) | 2008-05-15 |
| CN1871246A (zh) | 2006-11-29 |
| GT200400213A (es) | 2007-09-05 |
| PA8615401A1 (es) | 2005-11-25 |
| BRPI0415857A (pt) | 2007-01-09 |
| CO5690562A2 (es) | 2006-10-31 |
| TW200514775A (en) | 2005-05-01 |
| WO2005040176A3 (en) | 2005-12-01 |
| MXPA06004397A (es) | 2006-06-14 |
| PE20050908A1 (es) | 2005-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |