AR074230A1 - Proceso para preparar acido zoledronico - Google Patents
Proceso para preparar acido zoledronicoInfo
- Publication number
- AR074230A1 AR074230A1 ARP090104567A ARP090104567A AR074230A1 AR 074230 A1 AR074230 A1 AR 074230A1 AR P090104567 A ARP090104567 A AR P090104567A AR P090104567 A ARP090104567 A AR P090104567A AR 074230 A1 AR074230 A1 AR 074230A1
- Authority
- AR
- Argentina
- Prior art keywords
- intermediates
- formula
- prepare
- zoledronic acid
- salt
- Prior art date
Links
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 title 1
- 229960004276 zoledronic acid Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000005676 cyclic carbonates Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
La invencion se relaciona con un proceso, el cual comprende: hacer reaccionar en un solvente/diluyente un compuesto de formula (2) o una sal o éster del mismo con un agente de fosfonacion para formar intermediarios fosfonados, y subsiguientemente hidrolizar dichos intermediarios para formar un compuesto de formula (1) o una sal o hidrato del mismo en donde dicho solvente/diluyente comprende una mezcla de (i) un polialquilenglicol y (ii) un carbonato cíclico de la formula (3) en donde n es un entero desde 2 a 4, y R1 y R2 cada uno independientemente representan hidrogeno o un grupo alquilo C1-4 y al uso de intermediaros en el mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11805008P | 2008-11-26 | 2008-11-26 | |
| EP08075904A EP2192126B1 (en) | 2008-11-26 | 2008-11-26 | Process for making zoledronic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074230A1 true AR074230A1 (es) | 2010-12-29 |
Family
ID=41402559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104567A AR074230A1 (es) | 2008-11-26 | 2009-11-26 | Proceso para preparar acido zoledronico |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR074230A1 (es) |
| WO (1) | WO2010060619A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2459176T1 (en) | 2009-07-31 | 2018-01-31 | Gruenenthal Gmbh | Crystallization process and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EA201270328A1 (ru) * | 2009-08-28 | 2012-09-28 | Синтон Б. В. | Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| CN111303040A (zh) * | 2020-03-25 | 2020-06-19 | 武汉工程大学 | 一种一锅法制备咪唑-1-乙酸的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| WO2003097655A1 (en) * | 2002-05-17 | 2003-11-27 | Teva Pharmaceutical Industries Ltd. | Use of certain diluents for making bisphosphonic acids |
| WO2005063717A1 (en) * | 2003-12-26 | 2005-07-14 | Natco Pharma Limited | An improved process for the preparation of zoledronic acid |
-
2009
- 2009-11-24 WO PCT/EP2009/008424 patent/WO2010060619A1/en active Application Filing
- 2009-11-26 AR ARP090104567A patent/AR074230A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010060619A1 (en) | 2010-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |