IL103330A - Benzimidazole phosphono-amino acids their preparation and pharmaceutical compositions containing them - Google Patents

Benzimidazole phosphono-amino acids their preparation and pharmaceutical compositions containing them

Info

Publication number
IL103330A
IL103330A IL10333092A IL10333092A IL103330A IL 103330 A IL103330 A IL 103330A IL 10333092 A IL10333092 A IL 10333092A IL 10333092 A IL10333092 A IL 10333092A IL 103330 A IL103330 A IL 103330A
Authority
IL
Israel
Prior art keywords
compound
amino
pharmaceutically acceptable
benzimidazole
formula
Prior art date
Application number
IL10333092A
Other languages
English (en)
Other versions
IL103330A0 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL103330A0 publication Critical patent/IL103330A0/xx
Publication of IL103330A publication Critical patent/IL103330A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IL10333092A 1991-10-11 1992-10-02 Benzimidazole phosphono-amino acids their preparation and pharmaceutical compositions containing them IL103330A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/776,528 US5124319A (en) 1991-10-11 1991-10-11 Benzimidazole phosphono-amino acids

Publications (2)

Publication Number Publication Date
IL103330A0 IL103330A0 (en) 1993-03-15
IL103330A true IL103330A (en) 1996-10-31

Family

ID=25107643

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10333092A IL103330A (en) 1991-10-11 1992-10-02 Benzimidazole phosphono-amino acids their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US5124319A (es)
EP (1) EP0539057B1 (es)
JP (1) JPH05222077A (es)
KR (1) KR930007961A (es)
AT (1) ATE155473T1 (es)
AU (1) AU656811B2 (es)
CA (1) CA2080253A1 (es)
CZ (1) CZ308392A3 (es)
DE (1) DE69220879T2 (es)
DK (1) DK0539057T3 (es)
ES (1) ES2104841T3 (es)
FI (1) FI924570L (es)
GR (1) GR3024767T3 (es)
HU (2) HUT62196A (es)
IL (1) IL103330A (es)
MX (1) MX9205816A (es)
NO (1) NO300690B1 (es)
NZ (1) NZ244587A (es)
RU (1) RU2073004C1 (es)
SG (1) SG47768A1 (es)
SK (1) SK279381B6 (es)
ZA (1) ZA927535B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334618A (en) * 1991-04-04 1994-08-02 The Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
IS4233A (is) * 1993-12-22 1995-06-23 Astra Aktiebolag Misleit hringtengd efnasambönd
US5864040A (en) * 1996-01-11 1999-01-26 American Home Products Corporation Benzimidazole phosphono-amino acids
AU6452098A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
ZA981936B (en) * 1997-03-07 1999-09-06 Metabasis Therapeutics Inc Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
GB9917822D0 (en) * 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6316474B1 (en) * 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
JP2005506292A (ja) * 2001-03-08 2005-03-03 エモリー　ユニバーシティ ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
CN1863810B (zh) * 2003-04-09 2010-12-01 惠氏公司 [2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用
BRPI0409088A (pt) * 2003-04-09 2006-04-11 Wyeth Corp composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) * 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
AU2008272964A1 (en) 2007-06-29 2009-01-08 Emory University NMDA receptor antagonists for neuroprotection
JP2010537999A (ja) * 2007-08-27 2010-12-09 ワイス・エルエルシー 麻酔薬節約効果を得るためのｎｍｄａ拮抗薬を用いる組成物および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU959724A1 (ru) * 1981-05-06 1982-09-23 Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт Способ регулировани роста растений огурца
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids

Also Published As

Publication number Publication date
MX9205816A (es) 1993-07-01
SK308392A3 (en) 1995-02-08
EP0539057B1 (en) 1997-07-16
ZA927535B (en) 1994-03-30
DK0539057T3 (da) 1998-02-09
GR3024767T3 (en) 1997-12-31
EP0539057A1 (en) 1993-04-28
FI924570A7 (fi) 1993-04-12
SK279381B6 (sk) 1998-10-07
FI924570A0 (fi) 1992-10-09
SG47768A1 (en) 1998-04-17
US5124319A (en) 1992-06-23
NO923940L (no) 1993-04-13
NZ244587A (en) 1994-04-27
CA2080253A1 (en) 1993-04-12
ES2104841T3 (es) 1997-10-16
ATE155473T1 (de) 1997-08-15
HU9203203D0 (en) 1992-12-28
DE69220879D1 (de) 1997-08-21
DE69220879T2 (de) 1997-11-20
KR930007961A (ko) 1993-05-20
JPH05222077A (ja) 1993-08-31
HUT62196A (en) 1993-04-28
CZ308392A3 (en) 1993-08-11
AU656811B2 (en) 1995-02-16
IL103330A0 (en) 1993-03-15
FI924570L (fi) 1993-04-12
RU2073004C1 (ru) 1997-02-10
NO300690B1 (no) 1997-07-07
AU2626992A (en) 1993-04-22
HU211942A9 (en) 1996-01-29
NO923940D0 (no) 1992-10-09

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HCA Change of name of proprietor(s) after amalgamation
RH1 Patent not in force