KR930007961A - 벤즈이미다졸 포스포노-아미노산 - Google Patents

벤즈이미다졸 포스포노-아미노산 Download PDF

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Publication number
KR930007961A
KR930007961A KR1019920018638A KR920018638A KR930007961A KR 930007961 A KR930007961 A KR 930007961A KR 1019920018638 A KR1019920018638 A KR 1019920018638A KR 920018638 A KR920018638 A KR 920018638A KR 930007961 A KR930007961 A KR 930007961A
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South Korea
Prior art keywords
benzimidazole
compound
amino
lower alkyl
phosphonomethyl
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KR1019920018638A
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English (en)
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베른하르트 바우디 라인하르트
플렛처 3세 호레이스
패트릭 야들이 존
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원본미기재
아메리칸 홈 프로덕츠 코포레이션
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Publication of KR930007961A publication Critical patent/KR930007961A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

하기 일반식의 화합물 또는 약리학적으로 허용되는 이의 염은 흥분성 아미노산 수용체의 과도흥분으로 인한 중추신경계 관련 장애를 치료하고 예방하는데 유용한 NMDA 길항제이다.
상기식에서, R은 수소, 저급 알킬, 벤질 또는 피발로일옥시메틸이고, R1및 R2는 독립적으로 수소, 저급 알킬, 저급 알콕시, 트리플루오로메틸, 트리플루오로메톡시, 메탄설포닐아미노, 아세틸아미노 또는 할로이거나, R1및 R2는 함께 메틸렌디옥시 그룹을 나타낸다.

Description

벤즈이미다졸 포스포노-아미노산
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식의 화합물 및 약리학적으로 허용되는 이의 염.
    상기식에서, R은 수소, 저급 알킬, 벤질 또는 피발로일옥시메틸이고, R1및 R2는 독립적으로 수소, 저급 알킬, 저급 알콕시, 트리플루오로메틸, 트리플루오로메톡시, 메탄설포닐아미노, 아세틸아미노 또는 할로이거나, R1및 R2는 함께 메틸렌디옥시 그룹을 나타낸다.
  2. 제1항에 있어서, R-α-아미노-1-(포스포노메틸)-1H-벤즈이미다졸-2-프로파노산인 화합물.
  3. 제1항에 있어서, R-α-아미노-5,6-디클로로-1-(포스포노메틸)-1H-벤즈이미다졸-2-프로파노산인 화합물.
  4. 제1항에 있어서, R-α-아미노-5,6-디메틸-1-(포스포노메틸)-1H-벤즈이미다졸-2-프로파노산인 화합물.
  5. 제1항에 있어서, R-α-아미노-6-클로로-1-(포스포노메틸)-1H-벤즈이미다졸-2-프로파노산인 화합물.
  6. 제1항에 있어서, R-α-아미노-5-클로로-1-(포스포노메틸)-1H-벤즈이미다졸-2-프로파노산인 화합물.
  7. 흥분성 아미노산 수용체의 과도흥분으로 인한 신경장애가 있는 포유동물에게 NMDA 길항제만 하기 일반식의 화합물 또는 약리학적으로 허용되는 이의 염을 신경보호량으로 투여함을 특징으로 하여, 흥분성 아미노산 수용체의 과도흥분으로 인한 신경장애를 치료하고 예방하는 방법.
    상기식에서, R은 수소, 저급 알킬, 벤질 또는 피발로일옥시메틸이고, R1및 R2는 독립적으로 수소, 저급 알킬, 저급 알콕시, 트리플루오로메틸, 트리플루오로메톡시, 메탄설포닐아미노, 아세틸아미노 또는 할로이거나, R1및 R2는 함께 메틸렌디옥시 그룹을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920018638A 1991-10-11 1992-10-10 벤즈이미다졸 포스포노-아미노산 KR930007961A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/776,528 US5124319A (en) 1991-10-11 1991-10-11 Benzimidazole phosphono-amino acids
US07/776,528 1991-10-11

Publications (1)

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KR930007961A true KR930007961A (ko) 1993-05-20

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US (1) US5124319A (ko)
EP (1) EP0539057B1 (ko)
JP (1) JPH05222077A (ko)
KR (1) KR930007961A (ko)
AT (1) ATE155473T1 (ko)
AU (1) AU656811B2 (ko)
CA (1) CA2080253A1 (ko)
CZ (1) CZ308392A3 (ko)
DE (1) DE69220879T2 (ko)
DK (1) DK0539057T3 (ko)
ES (1) ES2104841T3 (ko)
FI (1) FI924570A (ko)
GR (1) GR3024767T3 (ko)
HU (2) HUT62196A (ko)
IL (1) IL103330A (ko)
MX (1) MX9205816A (ko)
NO (1) NO300690B1 (ko)
NZ (1) NZ244587A (ko)
RU (1) RU2073004C1 (ko)
SG (1) SG47768A1 (ko)
SK (1) SK279381B6 (ko)
ZA (1) ZA927535B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334618A (en) * 1991-04-04 1994-08-02 The Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
IS4233A (is) * 1993-12-22 1995-06-23 Astra Aktiebolag Misleit hringtengd efnasambönd
US5864040A (en) * 1996-01-11 1999-01-26 American Home Products Corporation Benzimidazole phosphono-amino acids
DK0970095T3 (da) * 1997-03-07 2004-03-08 Metabasis Therapeutics Inc Hidtil ukendte benzimidazolinhibitorer for fructose-1,6-bisphosphase
AU6452098A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
GB9917822D0 (en) * 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6316474B1 (en) * 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US7375136B2 (en) * 2001-03-08 2008-05-20 Emory University pH-dependent NMDA receptor antagonists
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
PL1611144T3 (pl) * 2003-04-09 2011-03-31 Wyeth Llc Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA)
BRPI0409088A (pt) * 2003-04-09 2006-04-11 Wyeth Corp composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) * 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
AU2008272964A1 (en) * 2007-06-29 2009-01-08 Emory University NMDA receptor antagonists for neuroprotection
JP2010537999A (ja) * 2007-08-27 2010-12-09 ワイス・エルエルシー 麻酔薬節約効果を得るためのｎｍｄａ拮抗薬を用いる組成物および方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU959724A1 (ru) * 1981-05-06 1982-09-23 Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт Способ регулировани роста растений огурца
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids

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ATE155473T1 (de) 1997-08-15
ZA927535B (en) 1994-03-30
IL103330A0 (en) 1993-03-15
NO923940L (no) 1993-04-13
SK279381B6 (sk) 1998-10-07
CZ308392A3 (en) 1993-08-11
JPH05222077A (ja) 1993-08-31
AU656811B2 (en) 1995-02-16
CA2080253A1 (en) 1993-04-12
RU2073004C1 (ru) 1997-02-10
GR3024767T3 (en) 1997-12-31
MX9205816A (es) 1993-07-01
AU2626992A (en) 1993-04-22
ES2104841T3 (es) 1997-10-16
HUT62196A (en) 1993-04-28
SK308392A3 (en) 1995-02-08
EP0539057B1 (en) 1997-07-16
NZ244587A (en) 1994-04-27
IL103330A (en) 1996-10-31
NO923940D0 (no) 1992-10-09
NO300690B1 (no) 1997-07-07
FI924570A0 (fi) 1992-10-09
DE69220879D1 (de) 1997-08-21
DK0539057T3 (da) 1998-02-09
HU9203203D0 (en) 1992-12-28
SG47768A1 (en) 1998-04-17
US5124319A (en) 1992-06-23
HU211942A9 (en) 1996-01-29
DE69220879T2 (de) 1997-11-20
EP0539057A1 (en) 1993-04-28
FI924570A (fi) 1993-04-12

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