ZA927535B - Benzimidazole phosphono-amino acids - Google Patents
Benzimidazole phosphono-amino acidsInfo
- Publication number
- ZA927535B ZA927535B ZA927535A ZA927535A ZA927535B ZA 927535 B ZA927535 B ZA 927535B ZA 927535 A ZA927535 A ZA 927535A ZA 927535 A ZA927535 A ZA 927535A ZA 927535 B ZA927535 B ZA 927535B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino acids
- hydrogen
- compounds
- lower alkyl
- phosphono
- Prior art date
Links
- -1 pivaloyloxymethyl Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003257 excitatory amino acid Substances 0.000 abstract 1
- 230000002461 excitatory amino acid Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Saccharide Compounds (AREA)
- Organic Insulating Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/776,528 US5124319A (en) | 1991-10-11 | 1991-10-11 | Benzimidazole phosphono-amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA927535B true ZA927535B (en) | 1994-03-30 |
Family
ID=25107643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA927535A ZA927535B (en) | 1991-10-11 | 1992-09-30 | Benzimidazole phosphono-amino acids |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5124319A (xx) |
| EP (1) | EP0539057B1 (xx) |
| JP (1) | JPH05222077A (xx) |
| KR (1) | KR930007961A (xx) |
| AT (1) | ATE155473T1 (xx) |
| AU (1) | AU656811B2 (xx) |
| CA (1) | CA2080253A1 (xx) |
| CZ (1) | CZ308392A3 (xx) |
| DE (1) | DE69220879T2 (xx) |
| DK (1) | DK0539057T3 (xx) |
| ES (1) | ES2104841T3 (xx) |
| FI (1) | FI924570A (xx) |
| GR (1) | GR3024767T3 (xx) |
| HU (2) | HUT62196A (xx) |
| IL (1) | IL103330A (xx) |
| MX (1) | MX9205816A (xx) |
| NO (1) | NO300690B1 (xx) |
| NZ (1) | NZ244587A (xx) |
| RU (1) | RU2073004C1 (xx) |
| SG (1) | SG47768A1 (xx) |
| SK (1) | SK279381B6 (xx) |
| ZA (1) | ZA927535B (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334618A (en) * | 1991-04-04 | 1994-08-02 | The Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| IS4233A (is) * | 1993-12-22 | 1995-06-23 | Astra Aktiebolag | Misleit hringtengd efnasambönd |
| US5864040A (en) * | 1996-01-11 | 1999-01-26 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| ATE253073T1 (de) * | 1997-03-07 | 2003-11-15 | Metabasis Therapeutics Inc | Neue benzimidazol inhibitoren der fructose-1,6- bisphosphatase |
| US6284748B1 (en) * | 1997-03-07 | 2001-09-04 | Metabasis Therapeutics, Inc. | Purine inhibitors of fructose 1,6-bisphosphatase |
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| US6316474B1 (en) * | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
| CA2440284A1 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
| UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20040082543A1 (en) * | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
| CA2521394A1 (en) * | 2003-04-09 | 2004-10-28 | Wyeth | Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof |
| BRPI0409255A (pt) * | 2003-04-09 | 2006-03-28 | Wyeth Corp | derivados de ácido 2-(8,9-dioxo-2,6-diazabi-ciclo(5.2.0)non-1(7)-en-2-il)alquil fosfÈnico e seu uso como antagonistas de receptores de d-asparto de -n-metila (nmda) |
| US20050142192A1 (en) * | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
| GT200400213A (es) * | 2003-10-22 | 2007-09-05 | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo | |
| CA2693032A1 (en) * | 2007-06-29 | 2009-01-08 | Emory University | Nmda receptor antagonists for neuroprotection |
| BRPI0815821A2 (pt) * | 2007-08-27 | 2015-02-18 | Wyeth Llc | Composições e métodos que empregam antagonistas nmda para alcançar um efeito poupador de anestésico. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU959724A1 (ru) * | 1981-05-06 | 1982-09-23 | Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт | Способ регулировани роста растений огурца |
| PH23848A (en) * | 1985-05-24 | 1989-11-23 | Ciba Geigy Ag | Certain phosphonic acids and derivatives |
| US4746653A (en) * | 1986-02-28 | 1988-05-24 | Ciba-Geigy Corporation | Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals |
| EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
-
1991
- 1991-10-11 US US07/776,528 patent/US5124319A/en not_active Expired - Lifetime
-
1992
- 1992-09-30 ZA ZA927535A patent/ZA927535B/xx unknown
- 1992-10-01 NZ NZ244587A patent/NZ244587A/xx unknown
- 1992-10-02 IL IL10333092A patent/IL103330A/en not_active IP Right Cessation
- 1992-10-08 EP EP92309160A patent/EP0539057B1/en not_active Expired - Lifetime
- 1992-10-08 SG SG1996004290A patent/SG47768A1/en unknown
- 1992-10-08 ES ES92309160T patent/ES2104841T3/es not_active Expired - Lifetime
- 1992-10-08 AU AU26269/92A patent/AU656811B2/en not_active Ceased
- 1992-10-08 AT AT92309160T patent/ATE155473T1/de not_active IP Right Cessation
- 1992-10-08 DK DK92309160.7T patent/DK0539057T3/da active
- 1992-10-08 DE DE69220879T patent/DE69220879T2/de not_active Expired - Fee Related
- 1992-10-09 CZ CS923083A patent/CZ308392A3/cs unknown
- 1992-10-09 CA CA002080253A patent/CA2080253A1/en not_active Abandoned
- 1992-10-09 MX MX9205816A patent/MX9205816A/es not_active IP Right Cessation
- 1992-10-09 JP JP4271403A patent/JPH05222077A/ja active Pending
- 1992-10-09 RU SU925053101A patent/RU2073004C1/ru active
- 1992-10-09 SK SK3083-92A patent/SK279381B6/sk unknown
- 1992-10-09 HU HU9203203A patent/HUT62196A/hu unknown
- 1992-10-09 FI FI924570A patent/FI924570A/fi unknown
- 1992-10-09 NO NO923940A patent/NO300690B1/no unknown
- 1992-10-10 KR KR1019920018638A patent/KR930007961A/ko not_active Application Discontinuation
-
1995
- 1995-06-21 HU HU95P/P00314P patent/HU211942A9/hu unknown
-
1997
- 1997-09-17 GR GR970402423T patent/GR3024767T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK279381B6 (sk) | 1998-10-07 |
| RU2073004C1 (ru) | 1997-02-10 |
| US5124319A (en) | 1992-06-23 |
| IL103330A (en) | 1996-10-31 |
| CA2080253A1 (en) | 1993-04-12 |
| IL103330A0 (en) | 1993-03-15 |
| HU9203203D0 (en) | 1992-12-28 |
| FI924570A (fi) | 1993-04-12 |
| NO923940D0 (no) | 1992-10-09 |
| JPH05222077A (ja) | 1993-08-31 |
| AU656811B2 (en) | 1995-02-16 |
| DE69220879D1 (de) | 1997-08-21 |
| AU2626992A (en) | 1993-04-22 |
| EP0539057B1 (en) | 1997-07-16 |
| SK308392A3 (en) | 1995-02-08 |
| HUT62196A (en) | 1993-04-28 |
| NO300690B1 (no) | 1997-07-07 |
| CZ308392A3 (en) | 1993-08-11 |
| ES2104841T3 (es) | 1997-10-16 |
| GR3024767T3 (en) | 1997-12-31 |
| ATE155473T1 (de) | 1997-08-15 |
| KR930007961A (ko) | 1993-05-20 |
| DE69220879T2 (de) | 1997-11-20 |
| HU211942A9 (en) | 1996-01-29 |
| EP0539057A1 (en) | 1993-04-28 |
| DK0539057T3 (da) | 1998-02-09 |
| NZ244587A (en) | 1994-04-27 |
| NO923940L (no) | 1993-04-13 |
| SG47768A1 (en) | 1998-04-17 |
| MX9205816A (es) | 1993-07-01 |
| FI924570A0 (fi) | 1992-10-09 |
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