SG47768A1 - Benzimidazole phosphono-amino acids - Google Patents

Benzimidazole phosphono-amino acids

Info

Publication number
SG47768A1
SG47768A1 SG1996004290A SG1996004290A SG47768A1 SG 47768 A1 SG47768 A1 SG 47768A1 SG 1996004290 A SG1996004290 A SG 1996004290A SG 1996004290 A SG1996004290 A SG 1996004290A SG 47768 A1 SG47768 A1 SG 47768A1
Authority
SG
Singapore
Prior art keywords
amino acids
hydrogen
compounds
lower alkyl
phosphono
Prior art date
Application number
SG1996004290A
Other languages
English (en)
Inventor
Reinhardt Bernhard Baudy
Horace Fletcher Iii
John Patrick Yardley
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of SG47768A1 publication Critical patent/SG47768A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/6506Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SG1996004290A 1991-10-11 1992-10-08 Benzimidazole phosphono-amino acids SG47768A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/776,528 US5124319A (en) 1991-10-11 1991-10-11 Benzimidazole phosphono-amino acids

Publications (1)

Publication Number Publication Date
SG47768A1 true SG47768A1 (en) 1998-04-17

Family

ID=25107643

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996004290A SG47768A1 (en) 1991-10-11 1992-10-08 Benzimidazole phosphono-amino acids

Country Status (22)

Country Link
US (1) US5124319A (xx)
EP (1) EP0539057B1 (xx)
JP (1) JPH05222077A (xx)
KR (1) KR930007961A (xx)
AT (1) ATE155473T1 (xx)
AU (1) AU656811B2 (xx)
CA (1) CA2080253A1 (xx)
CZ (1) CZ308392A3 (xx)
DE (1) DE69220879T2 (xx)
DK (1) DK0539057T3 (xx)
ES (1) ES2104841T3 (xx)
FI (1) FI924570A (xx)
GR (1) GR3024767T3 (xx)
HU (2) HUT62196A (xx)
IL (1) IL103330A (xx)
MX (1) MX9205816A (xx)
NO (1) NO300690B1 (xx)
NZ (1) NZ244587A (xx)
RU (1) RU2073004C1 (xx)
SG (1) SG47768A1 (xx)
SK (1) SK279381B6 (xx)
ZA (1) ZA927535B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334618A (en) * 1991-04-04 1994-08-02 The Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
IS4233A (is) * 1993-12-22 1995-06-23 Astra Aktiebolag Misleit hringtengd efnasambönd
US5864040A (en) * 1996-01-11 1999-01-26 American Home Products Corporation Benzimidazole phosphono-amino acids
DE69819311T2 (de) 1997-03-07 2004-07-29 Metabasis Therapeutics Inc., San Diego Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
GB9917822D0 (en) * 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6316474B1 (en) * 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
EP1436258A4 (en) * 2001-03-08 2005-03-23 Univ Emory ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH
UA78529C2 (en) * 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) * 2002-10-29 2004-04-29 Pharmacia Corporation Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
EP1622625A1 (en) * 2003-04-09 2006-02-08 Wyeth Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.o] non-1 (7)-en-2-yl )alkyl] phosphonic acid and derivatives and methods of use thereof
CN1863810B (zh) * 2003-04-09 2010-12-01 惠氏公司 [2-(8,9-二氧代-2,6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用
US20050142192A1 (en) * 2003-10-15 2005-06-30 Wyeth Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
GT200400213A (es) * 2003-10-22 2007-09-05 Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo
CN101815518B (zh) * 2007-06-29 2013-01-09 埃莫里大学 用于神经保护的nmda受体拮抗剂
KR20100049663A (ko) * 2007-08-27 2010-05-12 와이어쓰 엘엘씨 마취제-절감 효과를 달성하기 위해 nmda 길항제를 사용하는 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU959724A1 (ru) * 1981-05-06 1982-09-23 Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт Способ регулировани роста растений огурца
PH23848A (en) * 1985-05-24 1989-11-23 Ciba Geigy Ag Certain phosphonic acids and derivatives
US4746653A (en) * 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5124319A (en) * 1991-10-11 1992-06-23 American Home Products Corporation Benzimidazole phosphono-amino acids

Also Published As

Publication number Publication date
SK279381B6 (sk) 1998-10-07
JPH05222077A (ja) 1993-08-31
MX9205816A (es) 1993-07-01
US5124319A (en) 1992-06-23
NO300690B1 (no) 1997-07-07
ATE155473T1 (de) 1997-08-15
FI924570A0 (fi) 1992-10-09
RU2073004C1 (ru) 1997-02-10
HU211942A9 (en) 1996-01-29
EP0539057B1 (en) 1997-07-16
AU2626992A (en) 1993-04-22
NO923940D0 (no) 1992-10-09
SK308392A3 (en) 1995-02-08
HU9203203D0 (en) 1992-12-28
HUT62196A (en) 1993-04-28
IL103330A0 (en) 1993-03-15
DE69220879D1 (de) 1997-08-21
DK0539057T3 (da) 1998-02-09
CA2080253A1 (en) 1993-04-12
GR3024767T3 (en) 1997-12-31
ZA927535B (en) 1994-03-30
FI924570A (fi) 1993-04-12
KR930007961A (ko) 1993-05-20
ES2104841T3 (es) 1997-10-16
AU656811B2 (en) 1995-02-16
NZ244587A (en) 1994-04-27
NO923940L (no) 1993-04-13
CZ308392A3 (en) 1993-08-11
DE69220879T2 (de) 1997-11-20
IL103330A (en) 1996-10-31
EP0539057A1 (en) 1993-04-28

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