ES2123810T3 - Heterociclos utiles como antagonistas de neuroquinina. - Google Patents

Heterociclos utiles como antagonistas de neuroquinina.

Info

Publication number
ES2123810T3
ES2123810T3 ES94923781T ES94923781T ES2123810T3 ES 2123810 T3 ES2123810 T3 ES 2123810T3 ES 94923781 T ES94923781 T ES 94923781T ES 94923781 T ES94923781 T ES 94923781T ES 2123810 T3 ES2123810 T3 ES 2123810T3
Authority
ES
Spain
Prior art keywords
hetero cycles
cycles useful
neuroquinine
antagonists
neuroquinine antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923781T
Other languages
English (en)
Inventor
Scott Carson Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2123810T3 publication Critical patent/ES2123810T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) EN LA QUE G, J, L, M, M Y D TIENEN CUALQUIERA DE LOS SIGNIFICADOS DADOS EN LAS ESPECIFICACIONES, SUS N-OXIDOS, Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES, QUE SON ANTAGONISTAS NO PEPTIDOS DE LA NEUROQUININA A Y UTILES PARA EL TRATAMIENTO DEL ASMA, ETC. TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS, PROCESOS PARA PREPARAR LOS COMPUESTOS DE LA FORMULA (I) Y PRODUCTOS INTERMEDIOS.
ES94923781T 1993-08-17 1994-08-15 Heterociclos utiles como antagonistas de neuroquinina. Expired - Lifetime ES2123810T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939317104A GB9317104D0 (en) 1993-08-17 1993-08-17 Therapeutic heterocycles

Publications (1)

Publication Number Publication Date
ES2123810T3 true ES2123810T3 (es) 1999-01-16

Family

ID=10740632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923781T Expired - Lifetime ES2123810T3 (es) 1993-08-17 1994-08-15 Heterociclos utiles como antagonistas de neuroquinina.

Country Status (24)

Country Link
US (6) US5567700A (es)
EP (1) EP0714392B1 (es)
JP (1) JP3502386B2 (es)
KR (1) KR100359631B1 (es)
CN (1) CN1077573C (es)
AT (1) ATE172971T1 (es)
AU (1) AU677091B2 (es)
CA (1) CA2166800C (es)
CZ (1) CZ285299B6 (es)
DE (1) DE69414398T2 (es)
DK (1) DK0714392T3 (es)
ES (1) ES2123810T3 (es)
FI (1) FI111253B (es)
GB (2) GB9317104D0 (es)
HU (1) HU219586B (es)
IL (1) IL110672A (es)
MY (1) MY112102A (es)
NO (1) NO305657B1 (es)
NZ (1) NZ269575A (es)
PL (1) PL178426B1 (es)
RU (1) RU2153498C2 (es)
SK (1) SK281232B6 (es)
WO (1) WO1995005377A1 (es)
ZA (1) ZA946142B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
US5589489A (en) * 1993-12-15 1996-12-31 Zeneca Limited Cyclic amide derivatives for treating asthma
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
TW432061B (en) * 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
EP0709375B1 (en) * 1994-10-25 2005-05-18 AstraZeneca AB Therapeutic heterocycles
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
GB9508786D0 (en) * 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5688960A (en) * 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
US5696267A (en) * 1995-05-02 1997-12-09 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
IL135408A0 (en) * 1997-11-21 2001-05-20 Schering Corp Substituted oximes as neurokinin antagonists
GB9924141D0 (en) * 1998-10-30 1999-12-15 Zeneca Ltd Treatment of gastric asthma
US6063926A (en) * 1998-11-18 2000-05-16 Schering Corporation Substituted oximes as neurokinin antagonists
CA2355886C (en) * 1998-12-23 2006-10-31 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
US6204265B1 (en) 1998-12-23 2001-03-20 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
GB0015246D0 (en) * 2000-06-22 2000-08-16 Astrazeneca Ab Method for the treatment of urinary incontinence
SE0103668D0 (sv) * 2001-11-02 2001-11-02 Astrazeneca Ab Method for the treatment of overactive blader
SE0103795D0 (sv) 2001-11-02 2001-11-02 Astrazeneca Ab Compounds and method for the treatment of överactive bladder
US20100189797A1 (en) 2002-06-10 2010-07-29 Julien Mendlewicz Oral antidepressant formulation
TW200508221A (en) 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
GB0326407D0 (en) * 2003-11-12 2003-12-17 Glaxo Group Ltd Chemical compounds
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
GB0412865D0 (en) * 2004-06-09 2004-07-14 Glaxo Group Ltd Chemical compounds
AR057828A1 (es) 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US8106208B2 (en) * 2006-05-18 2012-01-31 Albireo Ab Benzamide compounds that act as NK receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676781B1 (fr) * 1991-05-23 1995-03-31 Peugeot Dispositif de refroidissement de l'air de suralimentation d'un moteur a combustion interne d'un vehicule.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles

Also Published As

Publication number Publication date
EP0714392A1 (en) 1996-06-05
GB9317104D0 (en) 1993-09-29
ZA946142B (en) 1995-02-17
ATE172971T1 (de) 1998-11-15
HU9503826D0 (en) 1996-02-28
HUT75113A (en) 1997-04-28
IL110672A (en) 1999-06-20
SK281232B6 (sk) 2001-01-18
GB9416442D0 (en) 1994-10-05
MY112102A (en) 2001-04-30
FI111253B (fi) 2003-06-30
US5861392A (en) 1999-01-19
IL110672A0 (en) 1994-11-11
US6444809B1 (en) 2002-09-03
PL178426B1 (pl) 2000-04-28
NO960630D0 (no) 1996-02-16
CA2166800C (en) 2006-06-06
CZ285299B6 (cs) 1999-06-16
KR100359631B1 (ko) 2003-01-24
CN1129449A (zh) 1996-08-21
DE69414398T2 (de) 1999-05-06
JP3502386B2 (ja) 2004-03-02
SK21096A3 (en) 1997-02-05
US20030187255A1 (en) 2003-10-02
US5567700A (en) 1996-10-22
EP0714392B1 (en) 1998-11-04
CA2166800A1 (en) 1995-02-23
JPH09501439A (ja) 1997-02-10
AU7388094A (en) 1995-03-14
NO960630L (no) 1996-02-16
AU677091B2 (en) 1997-04-10
FI960727A0 (fi) 1996-02-16
CN1077573C (zh) 2002-01-09
US5990130A (en) 1999-11-23
US6124279A (en) 2000-09-26
DE69414398D1 (de) 1998-12-10
DK0714392T3 (da) 2001-02-05
NO305657B1 (no) 1999-07-05
RU2153498C2 (ru) 2000-07-27
US7053213B2 (en) 2006-05-30
WO1995005377A1 (en) 1995-02-23
PL313075A1 (en) 1996-05-27
HU219586B (hu) 2001-05-28
NZ269575A (en) 1997-11-24
CZ43496A3 (en) 1996-05-15
FI960727A (fi) 1996-02-16

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