ES2110185T3 - Complejos de beta-lactama biciclica/parabeno. - Google Patents

Complejos de beta-lactama biciclica/parabeno.

Info

Publication number
ES2110185T3
ES2110185T3 ES94304442T ES94304442T ES2110185T3 ES 2110185 T3 ES2110185 T3 ES 2110185T3 ES 94304442 T ES94304442 T ES 94304442T ES 94304442 T ES94304442 T ES 94304442T ES 2110185 T3 ES2110185 T3 ES 2110185T3
Authority
ES
Spain
Prior art keywords
complexes
lactama
parabene
bicycle
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94304442T
Other languages
English (en)
Inventor
Jane Goedde Amos
Joseph Michael Indelicato
Carol Elaine Pasini
Susan Marie Reutzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2110185T3 publication Critical patent/ES2110185T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION PROPORCIONA COMPLEJOS DE LA FORMULA: EN DONDE X ES CLORO, HIDROGENO, VINILO, O -CH3, Z ES CH2, S, U O; N ES 0-5; Y ES FENILO O 1,4-CICLOHEXADIEN-1-IL; R1 Y R2 SON HIDROGENO O HIDROXI, CON LA PROVISION DE QUE R1 Y R2 NO SON AMBOS HIDROGENO Y R3 ES -COO-, -COO(ALQUILO C1-C4), -NO2 O EN DONDE R4 ES ALQUILO C1-4.
ES94304442T 1993-06-28 1994-06-20 Complejos de beta-lactama biciclica/parabeno. Expired - Lifetime ES2110185T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/084,651 US5412094A (en) 1993-06-28 1993-06-28 Bicyclic beta-lactam/paraben complexes

Publications (1)

Publication Number Publication Date
ES2110185T3 true ES2110185T3 (es) 1998-02-01

Family

ID=22186328

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94304442T Expired - Lifetime ES2110185T3 (es) 1993-06-28 1994-06-20 Complejos de beta-lactama biciclica/parabeno.

Country Status (25)

Country Link
US (1) US5412094A (es)
EP (1) EP0637587B1 (es)
JP (1) JPH0748383A (es)
KR (1) KR950000707A (es)
CN (1) CN1044246C (es)
AT (1) ATE159942T1 (es)
AU (1) AU674226B2 (es)
BR (1) BR9402561A (es)
CA (1) CA2126401A1 (es)
CO (1) CO4230098A1 (es)
CZ (1) CZ285452B6 (es)
DE (1) DE69406607T2 (es)
DK (1) DK0637587T3 (es)
ES (1) ES2110185T3 (es)
FI (1) FI106460B (es)
GR (1) GR3025563T3 (es)
HU (1) HU219484B (es)
IL (1) IL110103A (es)
NO (1) NO305480B1 (es)
NZ (1) NZ260791A (es)
PE (1) PE57294A1 (es)
PL (1) PL177317B1 (es)
RU (1) RU2134265C1 (es)
YU (1) YU40694A (es)
ZA (1) ZA944376B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2006500377A (ja) * 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
KR20120115492A (ko) * 2009-11-06 2012-10-18 바스프 에스이 ４―히드록시 벤조산 및 선택된 살충제의 결정질 복합체
CN105997931A (zh) * 2016-07-19 2016-10-12 南京正宽医药科技有限公司 一种头孢克肟胶囊及其制备方法
CN113845529B (zh) * 2021-10-15 2024-02-27 东南大学 一种头孢氨苄共晶化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
AT363594B (de) * 1978-02-01 1981-08-10 Biochemie Gmbh Verfahren zur herstellung eines neuen formamidkomplexes von 7-beta-(d-2-amino-2-phenylacetamido)-3-methylceph-3-emcarbonsaeure
US4534898A (en) * 1982-07-23 1985-08-13 Merck & Co., Inc. 1-Oxa-1-dethia-cephalosporin derivatives
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
YU46699B (sh) * 1987-10-06 1994-04-05 Eli Lilly And Co. Kristalni monohidratni oblik 1-karbacefalosporina
EP0341991A3 (en) * 1988-05-13 1991-08-28 Eli Lilly And Company Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5142042A (en) * 1989-01-23 1992-08-25 Purzer Pharmaceutical Co., Ltd. Process for preparing well crystallized alkali metal salts of 3, 7-substituted 7-aminocephalosporanic acid derivatives

Also Published As

Publication number Publication date
CA2126401A1 (en) 1994-12-29
DE69406607T2 (de) 1998-03-26
JPH0748383A (ja) 1995-02-21
DK0637587T3 (da) 1997-12-15
CO4230098A1 (es) 1995-10-19
PL303977A1 (en) 1995-01-09
IL110103A0 (en) 1994-10-07
US5412094A (en) 1995-05-02
HUT68087A (en) 1995-05-29
NZ260791A (en) 1997-01-29
DE69406607D1 (de) 1997-12-11
AU674226B2 (en) 1996-12-12
CZ285452B6 (cs) 1999-08-11
EP0637587B1 (en) 1997-11-05
EP0637587A1 (en) 1995-02-08
IL110103A (en) 1999-04-11
PE57294A1 (es) 1995-02-07
CN1044246C (zh) 1999-07-21
YU40694A (sh) 1996-10-18
HU9401935D0 (en) 1994-09-28
ATE159942T1 (de) 1997-11-15
KR950000707A (ko) 1995-01-03
FI943081A0 (fi) 1994-06-27
ZA944376B (en) 1995-12-20
BR9402561A (pt) 1995-03-28
NO942364D0 (es) 1994-06-21
FI106460B (fi) 2001-02-15
PL177317B1 (pl) 1999-10-29
RU2134265C1 (ru) 1999-08-10
CZ151994A3 (en) 1995-01-18
HU219484B (hu) 2001-04-28
FI943081A (fi) 1994-12-29
GR3025563T3 (en) 1998-03-31
NO942364L (no) 1994-12-29
AU6595094A (en) 1995-01-05
CN1106410A (zh) 1995-08-09
NO305480B1 (no) 1999-06-07

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