EP0341991A3 - Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof - Google Patents

Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof Download PDF

Info

Publication number
EP0341991A3
EP0341991A3 EP19890304705 EP89304705A EP0341991A3 EP 0341991 A3 EP0341991 A3 EP 0341991A3 EP 19890304705 EP19890304705 EP 19890304705 EP 89304705 A EP89304705 A EP 89304705A EP 0341991 A3 EP0341991 A3 EP 0341991A3
Authority
EP
European Patent Office
Prior art keywords
antibiotics
recovery
acceptable salts
mother liquors
novel pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890304705
Other languages
German (de)
French (fr)
Other versions
EP0341991A2 (en
Inventor
Gary Lowell Engel
Ralph Roberts Pfeiffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0341991A2 publication Critical patent/EP0341991A2/en
Publication of EP0341991A3 publication Critical patent/EP0341991A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pharmaceutically-acceptable anthraquinone-­ 1,5-disulfonate salts of selected cephalosporins and 1-carba(1-dethia)cephems are provided, as well as a process for preparing said salt forms.
EP19890304705 1988-05-13 1989-05-10 Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof Withdrawn EP0341991A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19347488A 1988-05-13 1988-05-13
US193474 1988-05-13

Publications (2)

Publication Number Publication Date
EP0341991A2 EP0341991A2 (en) 1989-11-15
EP0341991A3 true EP0341991A3 (en) 1991-08-28

Family

ID=22713792

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890304705 Withdrawn EP0341991A3 (en) 1988-05-13 1989-05-10 Method for recovery of antibiotics from mother liquors and novel pharmaceutically-acceptable salts thereof

Country Status (5)

Country Link
EP (1) EP0341991A3 (en)
JP (1) JPH0215078A (en)
KR (1) KR0135979B1 (en)
HU (1) HU203761B (en)
IL (1) IL90269A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434259A (en) * 1993-02-05 1995-07-18 Eli Lilly And Company Process for isolation of cefaclor after enzymatic acylation
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US6362410B1 (en) 1999-09-28 2002-03-26 Kabushiki Kaisha Kawai Gakki Seisakusho Electronic musical instrument

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2100968A1 (en) * 1970-07-29 1972-03-24 Lilly Co Eli
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608296A (en) * 1983-06-29 1985-01-17 ユング・ジン・フア−マシウテイカル・インダストリアル・カンパニイ・リミテツド Manufacture of cephalosporin derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2100968A1 (en) * 1970-07-29 1972-03-24 Lilly Co Eli
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions

Also Published As

Publication number Publication date
HU203761B (en) 1991-09-30
IL90269A0 (en) 1989-12-15
KR890017259A (en) 1989-12-15
JPH0215078A (en) 1990-01-18
EP0341991A2 (en) 1989-11-15
KR0135979B1 (en) 1998-04-25
IL90269A (en) 1994-02-27
HUT50350A (en) 1990-01-29

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