CO4230098A1 - Complejo b-lactama biciclica/parabeno - Google Patents

Complejo b-lactama biciclica/parabeno

Info

Publication number
CO4230098A1
CO4230098A1 CO94027493A CO94027493A CO4230098A1 CO 4230098 A1 CO4230098 A1 CO 4230098A1 CO 94027493 A CO94027493 A CO 94027493A CO 94027493 A CO94027493 A CO 94027493A CO 4230098 A1 CO4230098 A1 CO 4230098A1
Authority
CO
Colombia
Prior art keywords
parabene
bicycle
lactam complex
hydrogen
lactam
Prior art date
Application number
CO94027493A
Other languages
English (en)
Inventor
Amos Jane Goedde
Joseph Michael Indelicato
Carol Elaine Pasini
Susan Marie Reutzel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4230098A1 publication Critical patent/CO4230098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

REIVINDICACION NUMERO UN COMPLEJO DE LA FORMULA FIGURA 1. EN EL QUE X ES CLORO, HIDROGENO, VINILO O -CH3; Z ES CH2, S u O; n ES DE 0 A 5; Y ES FENILO O 1,4-CICLOHEXADIEN-1-ILO; R1 Y R2 SON HIDROGENO O HIDROXILO, CON LA CONDI- CION DE QUE R1 R2 NO SON AMBOS HIDROGENO Y R3 ES CO2H, -COO(ALQUILO C1-C4), -NO2-C(SUP =0)-R4, EN EL QUE R4 ES UN ALQUILO C1-C4".
CO94027493A 1993-06-28 1994-06-24 Complejo b-lactama biciclica/parabeno CO4230098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/084,651 US5412094A (en) 1993-06-28 1993-06-28 Bicyclic beta-lactam/paraben complexes

Publications (1)

Publication Number Publication Date
CO4230098A1 true CO4230098A1 (es) 1995-10-19

Family

ID=22186328

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94027493A CO4230098A1 (es) 1993-06-28 1994-06-24 Complejo b-lactama biciclica/parabeno

Country Status (25)

Country Link
US (1) US5412094A (es)
EP (1) EP0637587B1 (es)
JP (1) JPH0748383A (es)
KR (1) KR950000707A (es)
CN (1) CN1044246C (es)
AT (1) ATE159942T1 (es)
AU (1) AU674226B2 (es)
BR (1) BR9402561A (es)
CA (1) CA2126401A1 (es)
CO (1) CO4230098A1 (es)
CZ (1) CZ285452B6 (es)
DE (1) DE69406607T2 (es)
DK (1) DK0637587T3 (es)
ES (1) ES2110185T3 (es)
FI (1) FI106460B (es)
GR (1) GR3025563T3 (es)
HU (1) HU219484B (es)
IL (1) IL110103A (es)
NO (1) NO305480B1 (es)
NZ (1) NZ260791A (es)
PE (1) PE57294A1 (es)
PL (1) PL177317B1 (es)
RU (1) RU2134265C1 (es)
YU (1) YU40694A (es)
ZA (1) ZA944376B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
JP4906233B2 (ja) 2002-03-01 2012-03-28 ユニバーシティー オブ サウス フロリダ 少なくとも１種の有効薬剤成分を含有する多構成要素固相
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
MXPA05000232A (es) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
WO2011054741A2 (en) * 2009-11-06 2011-05-12 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
CN105997931A (zh) * 2016-07-19 2016-10-12 南京正宽医药科技有限公司 一种头孢克肟胶囊及其制备方法
CN113845529B (zh) * 2021-10-15 2024-02-27 东南大学 一种头孢氨苄共晶化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
GB1510794A (en) * 1974-08-06 1978-05-17 Univ Kingston 1-oxacephems and intermediates therefor
AT363594B (de) * 1978-02-01 1981-08-10 Biochemie Gmbh Verfahren zur herstellung eines neuen formamidkomplexes von 7-beta-(d-2-amino-2-phenylacetamido)-3-methylceph-3-emcarbonsaeure
US4534898A (en) * 1982-07-23 1985-08-13 Merck & Co., Inc. 1-Oxa-1-dethia-cephalosporin derivatives
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
DD273634A5 (de) * 1987-10-06 1989-11-22 ����@�����@�����@����k�� Verfahren zur herstellung eines kristallinen monohydrats eines 1-carbacephalosporins
KR0135979B1 (ko) * 1988-05-13 1998-04-25 메리 앤 터커 모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
US5142042A (en) * 1989-01-23 1992-08-25 Purzer Pharmaceutical Co., Ltd. Process for preparing well crystallized alkali metal salts of 3, 7-substituted 7-aminocephalosporanic acid derivatives

Also Published As

Publication number Publication date
AU674226B2 (en) 1996-12-12
PE57294A1 (es) 1995-02-07
PL177317B1 (pl) 1999-10-29
IL110103A0 (en) 1994-10-07
KR950000707A (ko) 1995-01-03
GR3025563T3 (en) 1998-03-31
DE69406607T2 (de) 1998-03-26
ZA944376B (en) 1995-12-20
NO305480B1 (no) 1999-06-07
RU2134265C1 (ru) 1999-08-10
FI106460B (fi) 2001-02-15
HU9401935D0 (en) 1994-09-28
JPH0748383A (ja) 1995-02-21
HU219484B (hu) 2001-04-28
HUT68087A (en) 1995-05-29
PL303977A1 (en) 1995-01-09
FI943081A (fi) 1994-12-29
US5412094A (en) 1995-05-02
NO942364L (no) 1994-12-29
YU40694A (sh) 1996-10-18
CZ151994A3 (en) 1995-01-18
ATE159942T1 (de) 1997-11-15
CZ285452B6 (cs) 1999-08-11
EP0637587A1 (en) 1995-02-08
NZ260791A (en) 1997-01-29
BR9402561A (pt) 1995-03-28
CA2126401A1 (en) 1994-12-29
ES2110185T3 (es) 1998-02-01
EP0637587B1 (en) 1997-11-05
AU6595094A (en) 1995-01-05
CN1106410A (zh) 1995-08-09
FI943081A0 (fi) 1994-06-27
IL110103A (en) 1999-04-11
NO942364D0 (es) 1994-06-21
CN1044246C (zh) 1999-07-21
DE69406607D1 (de) 1997-12-11
DK0637587T3 (da) 1997-12-15

Similar Documents

Publication Publication Date Title
CO4230098A1 (es) Complejo b-lactama biciclica/parabeno
EP1431275A4 (en) DIARYL ETHER DERIVATIVE, ITS ADDITIONAL SALT AND IMMUNOSUPPRESSEUR
FI955709A0 (fi) Indolokarbatsolijohdannaisten käyttö eturauhasen patologisten tilojen hoidossa
MY115311A (en) Optically active 2 - imidazoline - 5 - one derivatives as fungicides.
ATE168992T1 (de) 7-substituierte-9-substituierte glycylamido-6- demethyl-6-deoxytetracycline
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
HUP9904198A2 (hu) Új 2-imidazolin-5-ont tartalmazó fungicid készítmények
AU551618B2 (en) Pyridazinone derivatives
ES2084458T3 (es) Derivados del indano-1,3-diona y del indano-1,2,3-triona, sus procedimientos de preparacion y su aplicacion en terapeutica.
NZ304438A (en) Substituted triazole derivatives and antifungal compositions
ES8300757A1 (es) Un procedimiento para la produccion de nuevas isoxolil-indolaminas.
DE68907925D1 (de) Oxadiazolverbindungen, ihre herstellung und ihre verwendung als pestizide.
GR851530B (es)
ES8505693A1 (es) Procedimiento para preparar compuestos de organofosforo
MY118584A (en) Herbicidal tetrazolinones.