ES2107412T3 - Sistema autosostenido de replicacion de secuencias. - Google Patents

Sistema autosostenido de replicacion de secuencias.

Info

Publication number
ES2107412T3
ES2107412T3 ES89313154T ES89313154T ES2107412T3 ES 2107412 T3 ES2107412 T3 ES 2107412T3 ES 89313154 T ES89313154 T ES 89313154T ES 89313154 T ES89313154 T ES 89313154T ES 2107412 T3 ES2107412 T3 ES 2107412T3
Authority
ES
Spain
Prior art keywords
target nucleic
nucleic acid
self
dna
replication system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89313154T
Other languages
English (en)
Inventor
Thomas Raymond Gingeras
John C Guatelli
Kristina Marie Whitfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2107412T3 publication Critical patent/ES2107412T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Error Detection And Correction (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Reverberation, Karaoke And Other Acoustics (AREA)
  • Optical Communication System (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION PROVEE DETALLES DE UN SISTEMA DE AMPLIFICACION PARA LA DETECCION DE ACIDOS NUCLEICOS ANTICATODOS, MAS PARTICULARMENTE SECUENCIAS DE DICHOS ACIDOS EN UNA COMPOSICION ISOTERMAL DONDE TODOS LOS REAGENTES NECESARIOS PARA CONDUCIR LA AMPLIFICACION ESTAN PRESENTES, Y LAS REACCIONES SON AUTO-SOSTENIDAS Y CONTINUAS. SE CARACTERIZA LA DIGESTION ENZIMATICA SELECTIVA DE UN ARN/ADN DOBLE, FORMADA POR HIDRIDACION DEL PRIMER ADN CON EL ACIDO NUCLEICO, PARA LIBERAL EL PRIMER CORDON DE ADN PARA DESPUES HIBRIZARLO SEGUIDO DE LA PRIMERA EXTENSION QUE PROVEE UN ADN DOBLE QUE SIRVA COMO TEMPLADOR PARA PRODUCIR UNA PLURALIDAD DE COPIA QUE PUEDEN SER RECICLADAS Y/O DETECTADAS COMO TALES PARA DEDUCIR LA PRESENCIA DE LA SECUENCIA DE ACIDO NUCLEICO ANTICATODO.
ES89313154T 1988-12-16 1989-12-15 Sistema autosostenido de replicacion de secuencias. Expired - Lifetime ES2107412T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28546788A 1988-12-16 1988-12-16

Publications (1)

Publication Number Publication Date
ES2107412T3 true ES2107412T3 (es) 1997-12-01

Family

ID=23094358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89313154T Expired - Lifetime ES2107412T3 (es) 1988-12-16 1989-12-15 Sistema autosostenido de replicacion de secuencias.

Country Status (20)

Country Link
EP (2) EP0373960B1 (es)
JP (1) JP3152927B2 (es)
KR (1) KR0148265B1 (es)
AT (1) ATE156192T1 (es)
AU (2) AU4829690A (es)
BR (1) BR8907830A (es)
CA (1) CA2005589C (es)
DE (1) DE68928222T2 (es)
DK (1) DK175630B1 (es)
ES (1) ES2107412T3 (es)
FI (1) FI99143C (es)
GR (1) GR3024403T3 (es)
HU (1) HU216105B (es)
IL (2) IL92732A (es)
NO (1) NO311302B1 (es)
NZ (1) NZ231815A (es)
PT (1) PT92602B (es)
RU (1) RU2107729C1 (es)
WO (1) WO1990006995A1 (es)
ZA (1) ZA899593B (es)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753433A (en) * 1909-12-05 1998-05-19 Boehringer Mannheim Gmbh Method for the sensitive detection of nucleic acids
JP2650159B2 (ja) * 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
ES2091225T3 (es) * 1989-07-11 1996-11-01 Gen Probe Inc Metodos para la amplificacion de las secuencias de acidos nucleicos.
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
WO1991004340A1 (en) * 1989-09-20 1991-04-04 Cambridge Biotech Corporation In vitro, isothermal nucleic acid amplification
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
CA2087724C (en) * 1990-07-24 2003-09-16 John J. Sninsky Reduction of non-specific amplification during in vitro nucleic acid amplification using modified nucleic acid bases
ZA918965B (en) * 1990-11-13 1992-08-26 Siska Diagnostics Inc Nucleic acid amplification by two-enzyme,self-sustained sequence replication
AU9115891A (en) * 1990-11-14 1992-06-11 Siska Diagnostics, Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
JP3183510B2 (ja) 1990-12-31 2001-07-09 プロメガ・コーポレイシヨン Rnaレプリカーゼのdna依存性rnaポリメラーゼ活性を用いる核酸増幅
AU8997991A (en) * 1991-01-31 1992-08-06 Becton Dickinson & Company Exonuclease mediated strand displacement amplification
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
EP0525882B1 (en) * 1991-08-02 2004-01-14 bioMerieux B.V. Quantification of nucleic acid
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
DE4132133A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen herstellung von ribonukleinsaeuren
CA2135073C (en) * 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5843640A (en) * 1992-06-19 1998-12-01 Northwestern University Method of simultaneously detecting amplified nucleic acid sequences and cellular antigens in cells
WO1994023069A1 (en) 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5814442A (en) * 1994-06-10 1998-09-29 Georgetown University Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
US5770368A (en) * 1996-05-09 1998-06-23 Metropolitan Water District Of Southern California Cryptosporidium detection method
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
AT410218B (de) 1999-08-20 2003-03-25 Baxter Ag Verfahren zur herstellung eines qualitätsgesicherten pools biologischer proben
US6893847B2 (en) 2001-01-17 2005-05-17 Tosoh Corporation Oligonucleotide for detecting Salmonella and method of detecting Salmonella
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
WO2004040019A1 (ja) 2002-10-29 2004-05-13 Riken 核酸の増幅法
FR2855832B1 (fr) 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
EP3305919A1 (en) 2003-06-10 2018-04-11 The Trustees of Boston University Detection methods for disorders of the lung
FR2857375B1 (fr) 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
JP4790621B2 (ja) 2003-11-26 2011-10-12 アドバンディーエックス, インコーポレイテッド 特定のStaphylococcus種の分析のためのペプチド核酸プローブ
EP2415878A1 (en) 2003-12-25 2012-02-08 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
EP1564306B1 (en) 2004-02-17 2013-08-07 Affymetrix, Inc. Methods for fragmenting and labeling DNA
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2868433B1 (fr) 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
JP2006126204A (ja) 2004-10-29 2006-05-18 Affymetrix Inc ポリマーアレイを製造するための自動化方法
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
JP2008531039A (ja) 2005-02-28 2008-08-14 バイオクエスト インク 核酸分子が含まれる直接酵素反応方法
EP2360279A1 (en) 2005-04-14 2011-08-24 Trustees Of Boston University Diagnostic for lung disorders using class prediction
EP1882036B1 (en) 2005-05-17 2012-02-15 Ozgene Pty Ltd Sequential cloning system
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
FR2902430B1 (fr) 2005-11-25 2012-11-02 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence des genes h5 et n1 du virus d'influenza a
EP2605018A1 (en) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
JP2009539404A (ja) 2006-06-12 2009-11-19 オンコメチローム サイエンシズ エス.エイ. 大腸癌の早期検出および予後のためのメチル化マーカー
EP2520935A3 (en) 2006-08-09 2013-02-13 Homestead Clinical Corporation Organ-specific proteins and methods of their use
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US8026065B2 (en) 2006-11-02 2011-09-27 Yale University Assessment of oocyte competence
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
EP1956097A1 (en) 2007-02-06 2008-08-13 bioMerieux B.V. Method for discriminating single nucleotide polymorphisms (SNPs)
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
JP2009000063A (ja) 2007-06-22 2009-01-08 Tosoh Corp 改良されたノロウイルスrna検出方法
JP2010532986A (ja) 2007-07-09 2010-10-21 マイクロセンス メドテック リミテッド 改良された微生物の検出
EP2198042B1 (en) 2007-09-17 2016-11-02 MDxHealth SA Novel markers for bladder cancer detection
EP2201131B8 (en) 2007-09-17 2014-12-10 MDxHealth SA Improved methylation detection
WO2009044773A1 (ja) 2007-10-04 2009-04-09 Tosoh Corporation レジオネラ属菌rRNA増幅用プライマー、検出方法および検出キット
EP2071034A1 (en) 2007-12-12 2009-06-17 bioMérieux Method for treating a solution in order to destroy any ribonucleic acid after amplification
WO2009105549A2 (en) 2008-02-19 2009-08-27 Oncomethylome Sciences Sa Detection and prognosis of lung cancer
EP2626435B1 (en) 2008-03-21 2016-06-01 MDxHealth S.A. Detection and prognosis of cervical cancer
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2679750A1 (en) 2008-09-23 2010-03-23 Nexus Dx, Inc. Methods for detecting nucleic acids in a sample
EP2172563A1 (en) 2008-09-24 2010-04-07 bioMérieux S.A. Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
JP5428272B2 (ja) 2008-10-06 2014-02-26 東ソー株式会社 サバイビンmRNAの測定方法
FR2940805B1 (fr) 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
EP2379752B1 (fr) 2009-01-19 2015-09-30 Biomérieux S.A. Procedes pour determiner la susceptibilite a contracter une infection nosocomiale chez un patient et pour etablir un pronostic d'evolution d'un syndrome septique
DK2394170T3 (en) 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
EP3301446B1 (en) 2009-02-11 2020-04-15 Caris MPI, Inc. Molecular profiling of tumors
WO2010102823A1 (en) 2009-03-13 2010-09-16 Oncomethylome Sciences Sa Novel markers for bladder cancer detection
MX2011009597A (es) 2009-03-17 2012-05-29 Glaxosmithkline Biolog Sa Deteccion mejorada de la expresion del gen.
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
WO2011036173A1 (en) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
US20160186266A1 (en) 2009-10-27 2016-06-30 Carislife Sciences, Inc. Molecular profiling for personalized medicine
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
WO2011135058A2 (en) 2010-04-30 2011-11-03 Mdxhealth Sa Methods for detecting epigenetic modifications
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 HIF-2α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 HIF?2α 형질전환 마우스 및 이의 용도
JP5916718B2 (ja) 2010-06-04 2016-05-11 ビオメリューBiomerieux 結腸直腸癌の予後判定のための方法及びキット
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
EP2606150B1 (en) 2010-08-20 2016-03-16 Life Technologies Corporation Quantitative real-time pcr assay using fret dual-labeled primers
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
FR2970975B1 (fr) 2011-01-27 2016-11-04 Biomerieux Sa Procede et kit pour determiner in vitro le statut immunitaire d'un individu
AU2012214312A1 (en) 2011-02-09 2013-08-22 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
CA2827200A1 (en) 2011-02-24 2012-08-30 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a feline
WO2012118745A1 (en) 2011-02-28 2012-09-07 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
KR101291668B1 (ko) 2011-04-21 2013-08-01 서울대학교산학협력단 미코박테리아―대장균용 셔틀 벡터 및 이의 용도
EP2721175B1 (en) 2011-06-15 2015-09-16 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
WO2012177906A1 (en) 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
WO2013024173A1 (en) 2011-08-17 2013-02-21 Technische Universität München Computer implemented method for identifying regulatory regions or regulatory variations
GB201206209D0 (en) 2012-04-06 2012-05-23 Univ Leuven Kath Marker gene based diagnosis, staging and prognosis of prostate caner
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
BR112014014907A2 (pt) 2011-12-19 2017-06-13 Hills Pet Nutrition Inc composições e métodos para diagnóstico e tratamento de hipertireoidismo em animais de companhia
ES2904816T3 (es) 2012-02-27 2022-04-06 Becton Dickinson Co Composiciones para recuento molecular
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
AU2013266394B2 (en) 2012-05-21 2019-03-14 The Scripps Research Institute Methods of sample preparation
CA2878280A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
FR3000966B1 (fr) 2013-01-11 2016-10-28 Biomerieux Sa Procede pour etablir in vitro un pronostic de severite chez un patient en choc septique
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer
CN112037860B (zh) 2013-06-13 2024-02-23 豪夫迈·罗氏有限公司 用于非入侵性性染色体非整倍性确定的统计分析
WO2015018943A2 (en) 2013-08-08 2015-02-12 Institut Pasteur Correlation of disease activity with clonal expansions of human papillomavirus 16-specific cd8+ t-cells in patients with severe erosive oral lichen planus
GB2546833B (en) 2013-08-28 2018-04-18 Cellular Res Inc Microwell for single cell analysis comprising single cell and single bead oligonucleotide capture labels
CA2928014A1 (en) 2013-11-15 2015-05-21 Institut Pasteur Method for detecting a molecular marker of plasmodium falciparum artemisinin resistance
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
CA2960821A1 (en) 2014-09-09 2016-03-17 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 siRNA의 공동―운반용 나노복합체 및 이의 용도
GB201510684D0 (en) 2015-06-17 2015-08-05 Almac Diagnostics Ltd Gene signatures predictive of metastatic disease
US20180305748A1 (en) 2015-10-18 2018-10-25 Affymetrix, Inc. Multiallelic Genotyping of Single Nucleotide Polymorphisms and Indels
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
KR101845957B1 (ko) 2016-02-23 2018-04-05 전남대학교기술지주회사(주) 프로히비틴 유전자 타깃 백혈병 진단용 키트 및 이를 이용한 진단 방법
GB201605110D0 (en) 2016-03-24 2016-05-11 Mologic Ltd Detecting sepsis
ES2919927T3 (es) 2016-08-10 2022-07-29 Pasteur Institut Métodos y reactivos para la detección del paludismo por Plasmodium falciparum resistente a la piperaquina
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
EP3619533B1 (fr) 2017-05-05 2022-09-28 bioMérieux Procédé de détection d'une réponse cellulaire immune
WO2018223055A1 (en) 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
EP3707278A1 (en) 2017-11-09 2020-09-16 Alnylam Pharmaceuticals Inc. Assays and methods for determining expression of the lect2 gene
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
FR3085689A1 (fr) 2018-09-12 2020-03-13 Biomerieux Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu
CN112714797A (zh) 2018-06-29 2021-04-27 生物梅里埃公司 用于体外或离体确定个体免疫状态的方法
CA3121170A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
GB201902458D0 (en) 2019-02-22 2019-04-10 Mologic Ltd Treatment stratification for an excerbation of inflamation
EP3708678A1 (en) 2019-03-15 2020-09-16 Adisseo France S.A.S. Process for identifying a stress state in a subject
JP2022529294A (ja) 2019-04-17 2022-06-20 アイジェノミクス、ソシエダッド、リミターダ 子宮平滑筋腫および平滑筋肉腫の早期診断のための改良方法
FR3101358A1 (fr) 2019-09-27 2021-04-02 Bioaster Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
EP4038202A1 (fr) 2019-10-01 2022-08-10 Biomérieux Procédé pour déterminer la capacité d'un individu à répondre à un stimulus
FR3101423A1 (fr) 2019-10-01 2021-04-02 bioMérieux Procédé pour déterminer la capacité d’un individu à répondre à un stimulus
GB201914538D0 (en) 2019-10-08 2019-11-20 Momentum Bioscience Ltd Microorganism capture from antimicrobial-containing solution
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
EP4163397A1 (en) 2020-06-05 2023-04-12 Seegene, Inc. Specimen transport kit for detecting respiratory pathogens and methods for detecting respiratory pathogens using same
FR3112211A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112207A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112209A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de complication chez un patient
FR3112210A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112208A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
WO2022106795A1 (fr) 2020-11-20 2022-05-27 bioMérieux Procédé de classification d'un individu
FR3125065A1 (fr) 2021-07-08 2023-01-13 bioMérieux Procédé et kit de détection d’un virus respiratoire réplicatif
WO2023075394A1 (ko) 2021-10-29 2023-05-04 주식회사 씨젠 검체 채취 스왑 도구 및 호흡기 병원체의 검출 방법
FR3139579A1 (fr) 2022-09-09 2024-03-15 bioMérieux Procédé de détection in vitro ou ex vivo d’un statut immunodéprimé chez un sujet
WO2024110392A1 (en) 2022-11-22 2024-05-30 bioMérieux New nucleic acid binding compounds and uses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520110A (en) 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
EP0128042A3 (en) 1983-06-06 1985-01-16 Genentech, Inc. A process for indentifying or isolating a dna sequence, and a dna hybridization probe therefor
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340843C (en) * 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
GB9807888D0 (en) 1998-04-09 1998-06-10 Chirotech Technology Ltd Asymmetric hydrogenation

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JP3152927B2 (ja) 2001-04-03
KR910700335A (ko) 1991-03-14
HU216105B (hu) 1999-04-28
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AU4829690A (en) 1990-07-10
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HUT58793A (en) 1992-03-30
EP0778352A1 (en) 1997-06-11
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NO912328L (no) 1991-06-17
PT92602B (pt) 1997-03-31
EP0373960A3 (en) 1991-04-10
BR8907830A (pt) 1991-10-22
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DK175630B1 (da) 2004-12-27
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DE68928222D1 (de) 1997-09-04
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