ES2102602T3 - Mejoras en o relacionadas con benzotiofenos. - Google Patents

Mejoras en o relacionadas con benzotiofenos.

Info

Publication number
ES2102602T3
ES2102602T3 ES93305860T ES93305860T ES2102602T3 ES 2102602 T3 ES2102602 T3 ES 2102602T3 ES 93305860 T ES93305860 T ES 93305860T ES 93305860 T ES93305860 T ES 93305860T ES 2102602 T3 ES2102602 T3 ES 2102602T3
Authority
ES
Spain
Prior art keywords
benzothiophenes
raloxifene
medicament
manufacture
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93305860T
Other languages
English (en)
Inventor
Larry John Black
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25444642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2102602(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2102602T3 publication Critical patent/ES2102602T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Seal Device For Vehicle (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Prostheses (AREA)
  • Non-Volatile Memory (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)
  • Fertilizers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTA INVENCION PROPORCIONA COMPUESTOS, METODOS Y FORMULACIONES FARMACEUTICAS PARA USO EN EL TRATAMIENTO O PREVENCION DE LA OSTEOPOROSIS, MEDIANTE LA INHIBICION DE PERDIDA DE HUESO. ESTOS COMPUESTOS, METODOS Y FORMULACIONES PUEDEN USARSE SIN EFECTOS SECUNDARIOS ADVERSOS ASOCIADOS DE TERAPIA DE ESTROGENOS, Y DE ESTA FORMA RESULTAN EFICACES EN LA PREVENCION DEL TRATAMIENTO DE LA OSTEOPOROSIS.
ES93305860T 1992-07-28 1993-07-26 Mejoras en o relacionadas con benzotiofenos. Expired - Lifetime ES2102602T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92093392A 1992-07-28 1992-07-28

Publications (1)

Publication Number Publication Date
ES2102602T3 true ES2102602T3 (es) 1997-08-01

Family

ID=25444642

Family Applications (2)

Application Number Title Priority Date Filing Date
ES04101615T Expired - Lifetime ES2283939T3 (es) 1992-07-28 1993-07-26 Raloxifeno para el tratamiento de osteoporosis posmenopausica.
ES93305860T Expired - Lifetime ES2102602T3 (es) 1992-07-28 1993-07-26 Mejoras en o relacionadas con benzotiofenos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04101615T Expired - Lifetime ES2283939T3 (es) 1992-07-28 1993-07-26 Raloxifeno para el tratamiento de osteoporosis posmenopausica.

Country Status (35)

Country Link
US (4) US5393763A (es)
EP (4) EP0781555A1 (es)
JP (2) JP2749247B2 (es)
KR (1) KR0161300B1 (es)
CN (1) CN1054742C (es)
AT (2) ATE359074T1 (es)
AU (1) AU658075B2 (es)
BG (1) BG61429B1 (es)
BR (1) BR9303013A (es)
CA (1) CA2101356C (es)
CY (2) CY2044B1 (es)
CZ (1) CZ281913B6 (es)
DE (3) DE69334132T2 (es)
DK (2) DK0584952T3 (es)
ES (2) ES2283939T3 (es)
GR (1) GR3024171T3 (es)
HK (1) HK90197A (es)
HU (1) HU219233B (es)
IL (1) IL106450A (es)
LU (1) LU90334I2 (es)
MX (1) MX9304432A (es)
MY (1) MY111188A (es)
NL (1) NL980044I2 (es)
NO (2) NO303863B1 (es)
NZ (3) NZ248210A (es)
PH (1) PH30032A (es)
PL (1) PL177348B1 (es)
PT (1) PT1438957E (es)
RO (1) RO113212B1 (es)
RU (1) RU2104697C1 (es)
SA (1) SA93140340B1 (es)
SG (1) SG45315A1 (es)
TW (1) TW366342B (es)
UA (1) UA26213C2 (es)
ZA (1) ZA935283B (es)

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US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
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US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
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US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
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US6258826B1 (en) 1998-10-13 2001-07-10 Eli Lilly And Company Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome

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US5457117A (en) 1995-10-10
KR0161300B1 (ko) 1998-12-01
DE19975012I2 (de) 2003-05-22
JP2749247B2 (ja) 1998-05-13
IL106450A (en) 1999-12-31
EP1772150A1 (en) 2007-04-11
US20030212058A1 (en) 2003-11-13
KR940005270A (ko) 1994-03-21
HK90197A (en) 1997-08-01
PL299814A1 (en) 1994-02-07
CY2044B1 (en) 1998-04-30
IL106450A0 (en) 1993-11-15
JP3162662B2 (ja) 2001-05-08
ES2283939T3 (es) 2007-11-01
ATE359074T1 (de) 2007-05-15
ZA935283B (en) 1995-01-23
CA2101356C (en) 1998-11-17
NO932650D0 (no) 1993-07-22
PH30032A (en) 1996-11-08
NO1999006I1 (no) 1999-04-14
AU4422193A (en) 1994-02-03
BG97982A (bg) 1994-04-29
ATE152351T1 (de) 1997-05-15
JPH06199665A (ja) 1994-07-19
CZ281913B6 (cs) 1997-03-12
CN1054742C (zh) 2000-07-26
PL177348B1 (pl) 1999-10-29
AU658075C (en) 1994-02-03
EP1438957A1 (en) 2004-07-21
EP1438957B1 (en) 2007-04-11
NO932650L (no) 1994-01-31
DE69310288D1 (de) 1997-06-05
DK0584952T3 (da) 1997-10-13
MX9304432A (es) 1994-05-31
CN1088205A (zh) 1994-06-22
BR9303013A (pt) 1994-02-16
NL980044I1 (nl) 1999-03-01
SG45315A1 (en) 1998-01-16
RU2104697C1 (ru) 1998-02-20
HUT65707A (en) 1994-07-28
HU219233B (en) 2001-03-28
NL980044I2 (nl) 1999-06-01
MY111188A (en) 1999-09-30
EP0781555A1 (en) 1997-07-02
AU658075B2 (en) 1995-03-30
SA93140340B1 (ar) 2004-08-28
RO113212B1 (ro) 1998-05-29
DE69334132T2 (de) 2007-12-20
JPH10114656A (ja) 1998-05-06
GR3024171T3 (en) 1997-10-31
BG61429B1 (bg) 1997-08-29
DE69310288T2 (de) 1997-09-11
NO303863B1 (no) 1998-09-14
HU9302163D0 (en) 1993-10-28
DE69334132D1 (de) 2007-05-24
PT1438957E (pt) 2007-06-22
EP0584952A1 (en) 1994-03-02
NZ504611A (en) 2005-07-29
LU90334I2 (fr) 1999-02-23
EP0584952B1 (en) 1997-05-02
US6906086B2 (en) 2005-06-14
TW366342B (en) 1999-08-11
US5393763A (en) 1995-02-28
UA26213C2 (uk) 1999-07-19
CZ149893A3 (en) 1994-04-13
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CA2101356A1 (en) 1994-01-29
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US5534527A (en) 1996-07-09
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