ES2101848T3 - Productos analogos a los tocoferoles que bajan el porcentaje de colesterol. - Google Patents

Productos analogos a los tocoferoles que bajan el porcentaje de colesterol.

Info

Publication number
ES2101848T3
ES2101848T3 ES92912113T ES92912113T ES2101848T3 ES 2101848 T3 ES2101848 T3 ES 2101848T3 ES 92912113 T ES92912113 T ES 92912113T ES 92912113 T ES92912113 T ES 92912113T ES 2101848 T3 ES2101848 T3 ES 2101848T3
Authority
ES
Spain
Prior art keywords
tocopheroles
analoged
cholesterol
percentage
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92912113T
Other languages
English (en)
Inventor
Keith M Robinson
Eric W Heineke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2101848T3 publication Critical patent/ES2101848T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

ESTA INVENCION ES RELATIVA A DERIVADOS ALQUILOAMINO ALQUILENO DE CIERTOS 2H ORES DE COLESTEROL EN PLASMA Y A SU APLICACION DE USO FINAL COMO AGENTES TERAPEUTICOS.
ES92912113T 1991-06-05 1992-05-06 Productos analogos a los tocoferoles que bajan el porcentaje de colesterol. Expired - Lifetime ES2101848T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/710,647 US5135945A (en) 1991-06-05 1991-06-05 Cholesterol-lowering tocopherol analogs

Publications (1)

Publication Number Publication Date
ES2101848T3 true ES2101848T3 (es) 1997-07-16

Family

ID=24854940

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92912113T Expired - Lifetime ES2101848T3 (es) 1991-06-05 1992-05-06 Productos analogos a los tocoferoles que bajan el porcentaje de colesterol.

Country Status (16)

Country Link
US (1) US5135945A (es)
EP (1) EP0586518B1 (es)
JP (1) JP3072912B2 (es)
KR (1) KR100196973B1 (es)
AT (1) ATE149830T1 (es)
AU (1) AU665353B2 (es)
CA (1) CA2102812C (es)
DE (1) DE69218196T2 (es)
DK (1) DK0586518T3 (es)
ES (1) ES2101848T3 (es)
GR (1) GR3023646T3 (es)
HU (1) HUT65738A (es)
IE (1) IE921811A1 (es)
NO (1) NO304874B1 (es)
NZ (1) NZ242982A (es)
WO (1) WO1992021336A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
AU2474399A (en) 1998-01-26 1999-08-09 Mitokor Mitochondria protecting agents for treating mitochondria associated diseases
US6770672B1 (en) 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
IL142082A (en) 1998-09-23 2005-12-18 Res Dev Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses
US6703384B2 (en) * 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
DE60132171D1 (de) * 2000-02-11 2008-02-14 Res Dev Foundation Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung
US6436406B1 (en) * 2000-06-15 2002-08-20 A. Glenn Braswell Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis
US20030236301A1 (en) * 2001-12-19 2003-12-25 Bob Sanders Liposomal delivery of vitamin E based compounds
US20060128720A1 (en) * 2002-03-21 2006-06-15 Kufe Donald W Inhibition of cell death responses induced by oxidative stress

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
US4603142A (en) * 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
EP0369082A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
KR910007523A (ko) * 1989-10-04 1991-05-30 브리스톨-마이어즈 스퀴브 컴페니 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올

Also Published As

Publication number Publication date
DE69218196D1 (de) 1997-04-17
EP0586518A1 (en) 1994-03-16
EP0586518B1 (en) 1997-03-12
JP3072912B2 (ja) 2000-08-07
DK0586518T3 (da) 1997-04-01
IE921811A1 (en) 1992-12-16
AU665353B2 (en) 1996-01-04
NO934397L (no) 1993-12-03
NO304874B1 (no) 1999-03-01
JPH06508134A (ja) 1994-09-14
KR100196973B1 (ko) 1999-06-15
WO1992021336A1 (en) 1992-12-10
AU1993592A (en) 1993-01-08
HUT65738A (en) 1994-07-28
KR940701251A (ko) 1994-05-28
NZ242982A (en) 1997-03-24
NO934397D0 (no) 1993-12-03
CA2102812A1 (en) 1992-12-06
ATE149830T1 (de) 1997-03-15
GR3023646T3 (en) 1997-08-29
CA2102812C (en) 2004-03-30
US5135945A (en) 1992-08-04
DE69218196T2 (de) 1997-07-17

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