DK0586518T3 - Cholesterolnedsættende tocopherolanaloge - Google Patents

Cholesterolnedsættende tocopherolanaloge

Info

Publication number
DK0586518T3
DK0586518T3 DK92912113.5T DK92912113T DK0586518T3 DK 0586518 T3 DK0586518 T3 DK 0586518T3 DK 92912113 T DK92912113 T DK 92912113T DK 0586518 T3 DK0586518 T3 DK 0586518T3
Authority
DK
Denmark
Prior art keywords
cholesterol
lowering
tocopherol analogues
tocopherol
analogues
Prior art date
Application number
DK92912113.5T
Other languages
Danish (da)
English (en)
Inventor
Keith M Robinson
Eric W Heineke
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0586518T3 publication Critical patent/DK0586518T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK92912113.5T 1991-06-05 1992-05-06 Cholesterolnedsættende tocopherolanaloge DK0586518T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/710,647 US5135945A (en) 1991-06-05 1991-06-05 Cholesterol-lowering tocopherol analogs

Publications (1)

Publication Number Publication Date
DK0586518T3 true DK0586518T3 (da) 1997-04-01

Family

ID=24854940

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92912113.5T DK0586518T3 (da) 1991-06-05 1992-05-06 Cholesterolnedsættende tocopherolanaloge

Country Status (16)

Country Link
US (1) US5135945A (es)
EP (1) EP0586518B1 (es)
JP (1) JP3072912B2 (es)
KR (1) KR100196973B1 (es)
AT (1) ATE149830T1 (es)
AU (1) AU665353B2 (es)
CA (1) CA2102812C (es)
DE (1) DE69218196T2 (es)
DK (1) DK0586518T3 (es)
ES (1) ES2101848T3 (es)
GR (1) GR3023646T3 (es)
HU (1) HUT65738A (es)
IE (1) IE921811A1 (es)
NO (1) NO304874B1 (es)
NZ (1) NZ242982A (es)
WO (1) WO1992021336A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
WO1999037294A2 (en) 1998-01-26 1999-07-29 Mitokor Mitochondria protecting agents for treating mitochondria associated diseases
US6770672B1 (en) 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6703384B2 (en) * 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
IL142082A (en) 1998-09-23 2005-12-18 Res Dev Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses
NZ520798A (en) * 2000-02-11 2004-05-28 Res Dev Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6436406B1 (en) * 2000-06-15 2002-08-20 A. Glenn Braswell Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis
US20030236301A1 (en) * 2001-12-19 2003-12-25 Bob Sanders Liposomal delivery of vitamin E based compounds
CA2479257A1 (en) * 2002-03-21 2003-10-02 Dana-Farber Cancer Institute, Inc. Inhibition of cell death responses induced by oxidative stress

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
US4603142A (en) * 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
EP0369082A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
KR910007523A (ko) * 1989-10-04 1991-05-30 브리스톨-마이어즈 스퀴브 컴페니 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올

Also Published As

Publication number Publication date
DE69218196T2 (de) 1997-07-17
EP0586518A1 (en) 1994-03-16
ATE149830T1 (de) 1997-03-15
JP3072912B2 (ja) 2000-08-07
NZ242982A (en) 1997-03-24
JPH06508134A (ja) 1994-09-14
WO1992021336A1 (en) 1992-12-10
HUT65738A (en) 1994-07-28
DE69218196D1 (de) 1997-04-17
ES2101848T3 (es) 1997-07-16
AU1993592A (en) 1993-01-08
EP0586518B1 (en) 1997-03-12
KR100196973B1 (ko) 1999-06-15
NO934397L (no) 1993-12-03
NO934397D0 (no) 1993-12-03
IE921811A1 (en) 1992-12-16
CA2102812C (en) 2004-03-30
GR3023646T3 (en) 1997-08-29
AU665353B2 (en) 1996-01-04
NO304874B1 (no) 1999-03-01
KR940701251A (ko) 1994-05-28
CA2102812A1 (en) 1992-12-06
US5135945A (en) 1992-08-04

Similar Documents

Publication Publication Date Title
DK24089D0 (da) Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
ITMI920528A1 (it) 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
DE69430611D1 (de) Phosphonooxymethyl oder Methylthiomethylether von Taxanderivaten als Antitumormittel
ES2119826T3 (es) Derivados 2-oxoetilicos como inmunosupresores.
EP0458699A3 (en) Use of baclofen for the preparation of medicaments for the treatment of angina pectoris
NZ217016A (en) Zwitterionic bicyclic heterocyclic compounds, and pharmaceutical compositions containing such
DK0586518T3 (da) Cholesterolnedsættende tocopherolanaloge
ES2156120T3 (es) Derivados arilamidicos.
ES2162110T3 (es) Derivados de la quinolina antimalaria.
FI923752A (fi) Benso(f)kinolinoner
ES2182914T3 (es) Inmunopotenciacion inducida de quitosan.
DK0736029T3 (da) Antikonvulsive pseudofructopyranosesulfamater
FI910425A (fi) Di- och tetrafluoranaloger av skvalen som skvalenepoxidas-inhibitorer.
NO891703L (no) Farmasoeytiske sammensetninger for behandling av psoriasis.
ATE60762T1 (de) Oxothiazolidinderivate.
IT1270905B (it) Composizioni farmaceutiche contenenti n-acetilcarnosina per il trattamento della cataratta
ES2129053T3 (es) Nuevos derivados de fosfolipidos.
ES2037855T3 (es) Procedimiento para preparar nuevos derivados de 1-bencil-2-oxo-5-alcoxi-pirrolidina.