DE69218196D1 - Cholesterinsenkende tocopherolanaloga - Google Patents

Cholesterinsenkende tocopherolanaloga

Info

Publication number
DE69218196D1
DE69218196D1 DE69218196T DE69218196T DE69218196D1 DE 69218196 D1 DE69218196 D1 DE 69218196D1 DE 69218196 T DE69218196 T DE 69218196T DE 69218196 T DE69218196 T DE 69218196T DE 69218196 D1 DE69218196 D1 DE 69218196D1
Authority
DE
Germany
Prior art keywords
tocopherolanalog
cholester
lowing
certain
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69218196T
Other languages
English (en)
Other versions
DE69218196T2 (de
Inventor
Keith M Robinson
Eric W Heineke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69218196D1 publication Critical patent/DE69218196D1/de
Publication of DE69218196T2 publication Critical patent/DE69218196T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE69218196T 1991-06-05 1992-05-06 Cholesterinsenkende tocopherolanaloga Expired - Fee Related DE69218196T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/710,647 US5135945A (en) 1991-06-05 1991-06-05 Cholesterol-lowering tocopherol analogs
PCT/US1992/003738 WO1992021336A1 (en) 1991-06-05 1992-05-06 Cholesterol-lowering tocopherol analogs

Publications (2)

Publication Number Publication Date
DE69218196D1 true DE69218196D1 (de) 1997-04-17
DE69218196T2 DE69218196T2 (de) 1997-07-17

Family

ID=24854940

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218196T Expired - Fee Related DE69218196T2 (de) 1991-06-05 1992-05-06 Cholesterinsenkende tocopherolanaloga

Country Status (16)

Country Link
US (1) US5135945A (de)
EP (1) EP0586518B1 (de)
JP (1) JP3072912B2 (de)
KR (1) KR100196973B1 (de)
AT (1) ATE149830T1 (de)
AU (1) AU665353B2 (de)
CA (1) CA2102812C (de)
DE (1) DE69218196T2 (de)
DK (1) DK0586518T3 (de)
ES (1) ES2101848T3 (de)
GR (1) GR3023646T3 (de)
HU (1) HUT65738A (de)
IE (1) IE921811A1 (de)
NO (1) NO304874B1 (de)
NZ (1) NZ242982A (de)
WO (1) WO1992021336A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
WO1999037294A2 (en) 1998-01-26 1999-07-29 Mitokor Mitochondria protecting agents for treating mitochondria associated diseases
US6770672B1 (en) 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6703384B2 (en) * 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
IL142082A (en) 1998-09-23 2005-12-18 Res Dev Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses
NZ520798A (en) * 2000-02-11 2004-05-28 Res Dev Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6436406B1 (en) * 2000-06-15 2002-08-20 A. Glenn Braswell Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis
US20030236301A1 (en) * 2001-12-19 2003-12-25 Bob Sanders Liposomal delivery of vitamin E based compounds
CA2479257A1 (en) * 2002-03-21 2003-10-02 Dana-Farber Cancer Institute, Inc. Inhibition of cell death responses induced by oxidative stress

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
US4603142A (en) * 1984-06-01 1986-07-29 Wisconsin Alumni Research Foundation Cholesterol lowering method of use
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
EP0369082A1 (de) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Herzschutz-Tocopherolanaloge
KR910007523A (ko) * 1989-10-04 1991-05-30 브리스톨-마이어즈 스퀴브 컴페니 과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올

Also Published As

Publication number Publication date
DE69218196T2 (de) 1997-07-17
EP0586518A1 (de) 1994-03-16
ATE149830T1 (de) 1997-03-15
JP3072912B2 (ja) 2000-08-07
NZ242982A (en) 1997-03-24
JPH06508134A (ja) 1994-09-14
WO1992021336A1 (en) 1992-12-10
HUT65738A (en) 1994-07-28
ES2101848T3 (es) 1997-07-16
AU1993592A (en) 1993-01-08
EP0586518B1 (de) 1997-03-12
KR100196973B1 (ko) 1999-06-15
NO934397L (no) 1993-12-03
NO934397D0 (no) 1993-12-03
DK0586518T3 (da) 1997-04-01
IE921811A1 (en) 1992-12-16
CA2102812C (en) 2004-03-30
GR3023646T3 (en) 1997-08-29
AU665353B2 (en) 1996-01-04
NO304874B1 (no) 1999-03-01
KR940701251A (ko) 1994-05-28
CA2102812A1 (en) 1992-12-06
US5135945A (en) 1992-08-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee