ES2088936T3 - Compuestos fenoxi-heterociclicos. - Google Patents

Compuestos fenoxi-heterociclicos.

Info

Publication number
ES2088936T3
ES2088936T3 ES90120052T ES90120052T ES2088936T3 ES 2088936 T3 ES2088936 T3 ES 2088936T3 ES 90120052 T ES90120052 T ES 90120052T ES 90120052 T ES90120052 T ES 90120052T ES 2088936 T3 ES2088936 T3 ES 2088936T3
Authority
ES
Spain
Prior art keywords
alkyl
represented
benzo
alcoxyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90120052T
Other languages
English (en)
Inventor
Jules Freedman
Mark W Dudley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2088936T3 publication Critical patent/ES2088936T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRESENTE INVENCION SE DIRIGE A UNA CLASE DE COMPUESTOS HETEROCICLICOS FENOXI DE LA FORMULA I: EN LA CUAL R1 SE REPRESENTA POR HIDROGENO, HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, METILENODIOXI, ETILENODIOXI, METILENO, 2,3-BENZO, 3,4-BENZO, ALQUILTIO, ALQUILSULFONILO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; R2 SE REPRESENTA POR HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, ALQUILTIO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; R3 SE REPRESENTA POR HIDROGENO, HALOGENO, ALQUILO, ALCOXILO, OH, CF3, CN, METILENODIOXI, ETILENODIOXI, METILENO, 2,3-BENZO, 4,5-BENZO, 5,6-BENZO, ALQUILTIO, ALQUILSULFONILO, ALQUILSULFINILO, CICLOALQUILO, CICLOALCOXILO O CICLOALQUILTIO; M SE REPRESENTA POR UN ENTERO 1 O 2; P SE REPRESENTA POR UN ENTERO DE 0 A 4. TAMBIEN SE DIRIGE A LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES, Y A SU USO COMO AGENTES ANTI-DEPRESIVOS, ANXIOLITICOS Y ANTI-HIPERTENSIVOS.
ES90120052T 1989-10-20 1990-10-19 Compuestos fenoxi-heterociclicos. Expired - Lifetime ES2088936T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42442989A 1989-10-20 1989-10-20

Publications (1)

Publication Number Publication Date
ES2088936T3 true ES2088936T3 (es) 1996-10-01

Family

ID=23682608

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90120052T Expired - Lifetime ES2088936T3 (es) 1989-10-20 1990-10-19 Compuestos fenoxi-heterociclicos.

Country Status (21)

Country Link
EP (1) EP0423802B1 (es)
JP (1) JP3097696B2 (es)
KR (1) KR0182808B1 (es)
CN (1) CN1028099C (es)
AR (1) AR248400A1 (es)
AT (1) ATE126217T1 (es)
AU (1) AU627627B2 (es)
CA (1) CA2027530C (es)
DE (1) DE69021490T2 (es)
DK (1) DK0423802T3 (es)
ES (1) ES2088936T3 (es)
FI (1) FI104717B (es)
GR (1) GR3017775T3 (es)
HU (1) HU207300B (es)
IE (1) IE67049B1 (es)
IL (1) IL96064A (es)
NO (1) NO179367C (es)
NZ (1) NZ235688A (es)
PH (1) PH27290A (es)
PT (1) PT95637B (es)
ZA (1) ZA908234B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT625969E (pt) * 1992-02-06 2001-08-30 Merrell Pharma Inc Compostos de arilalcoxifenoxi-imidazolina
KR100693139B1 (ko) * 2001-04-19 2007-03-13 엘지전자 주식회사 디스크 드라이브의 트레이 진동방지구조
KR100482010B1 (ko) 2002-11-05 2005-04-14 삼성전자주식회사 모니터장치
EP1958507A1 (en) 2007-02-15 2008-08-20 Syngeta Participations AG Chemical compounds
WO2009003868A2 (en) * 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE614596C (de) * 1931-07-10 1935-06-13 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von ?-Glyoxalidinarylmethylolen
US2893993A (en) * 1958-06-17 1959-07-07 Searle & Co 2-aryloxyaralkyl-1, 4, 5, 6-tetrahydropyrimidines
US3897431A (en) * 1969-04-24 1975-07-29 Sterling Drug Inc 2-{8 {60 -Alkoxy-arylmethyl{9 -2-imidazolines and -1,4,5,6-tetrahydropyrimidines
NL7804482A (nl) * 1977-04-29 1978-10-31 Ciba Geigy Preparaten ter bestrijding van ectoparasieten.
DE2961710D1 (en) * 1978-10-09 1982-02-18 Ciba Geigy Ag 2-(alpha-phenoxy-alkyl)-imidazolines and their salts, their preparation and use, and agents against phytoparasitic and zooparasitic mites containing them
US4260626A (en) * 1979-03-26 1981-04-07 Richardson-Merrell Inc. Tetrahydro and imidazoline antisecretory compounds
IT1231237B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati eterociclici

Also Published As

Publication number Publication date
JPH03135960A (ja) 1991-06-10
CN1028099C (zh) 1995-04-05
AU6456590A (en) 1991-04-26
CA2027530C (en) 2001-05-08
IE903765A1 (en) 1991-04-24
GR3017775T3 (en) 1996-01-31
HU906514D0 (en) 1991-04-29
HUT55366A (en) 1991-05-28
ATE126217T1 (de) 1995-08-15
KR0182808B1 (ko) 1999-05-01
PT95637A (pt) 1991-09-13
FI905168A0 (fi) 1990-10-19
EP0423802A1 (en) 1991-04-24
IL96064A0 (en) 1991-07-18
DE69021490D1 (de) 1995-09-14
IL96064A (en) 1994-11-28
AU627627B2 (en) 1992-08-27
NO904535D0 (no) 1990-10-19
FI104717B (fi) 2000-03-31
DE69021490T2 (de) 1996-02-01
NO179367C (no) 1996-09-25
DK0423802T3 (da) 1995-09-18
PH27290A (en) 1993-05-04
JP3097696B2 (ja) 2000-10-10
CA2027530A1 (en) 1991-04-21
HU207300B (en) 1993-03-29
NO904535L (no) 1991-04-22
NO179367B (no) 1996-06-17
NZ235688A (en) 1992-02-25
IE67049B1 (en) 1996-02-21
CN1051039A (zh) 1991-05-01
AR248400A1 (es) 1995-08-18
ZA908234B (en) 1991-08-28
KR910007887A (ko) 1991-05-30
PT95637B (pt) 1998-04-30
EP0423802B1 (en) 1995-08-09

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