AR027607A1 - Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica - Google Patents

Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica

Info

Publication number
AR027607A1
AR027607A1 ARP010101022A ARP010101022A AR027607A1 AR 027607 A1 AR027607 A1 AR 027607A1 AR P010101022 A ARP010101022 A AR P010101022A AR P010101022 A ARP010101022 A AR P010101022A AR 027607 A1 AR027607 A1 AR 027607A1
Authority
AR
Argentina
Prior art keywords
preparation
derivatives
pirimidone
procedure
formula
Prior art date
Application number
ARP010101022A
Other languages
English (en)
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of AR027607A1 publication Critical patent/AR027607A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparacion de derivados de pirimidona de formula (1), caracterizado porque comprende hacer reaccionar un compuesto de formula (2)con un compuesto de formula (3) en presencia de una base. Los derivados de pirimidona de formula ( 1) son utiles como agentes antifungicos. Los sustituyentes R1, R2 y Ar y el nucleo A son tal como figura en la descripcion.
ARP010101022A 2000-03-07 2001-03-02 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica AR027607A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000625A ES2159488B1 (es) 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.

Publications (1)

Publication Number Publication Date
AR027607A1 true AR027607A1 (es) 2003-04-02

Family

ID=8492714

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101022A AR027607A1 (es) 2000-03-07 2001-03-02 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica

Country Status (17)

Country Link
US (1) US6653475B2 (es)
EP (1) EP1282084B9 (es)
JP (1) JP4772248B2 (es)
KR (1) KR100735583B1 (es)
AR (1) AR027607A1 (es)
AT (1) ATE250256T1 (es)
AU (1) AU2001237447A1 (es)
BR (1) BRPI0108990B8 (es)
CA (1) CA2402390C (es)
DE (1) DE60100810T2 (es)
DK (1) DK1282084T3 (es)
ES (2) ES2159488B1 (es)
HK (1) HK1052244B (es)
MX (1) MXPA02008556A (es)
NO (1) NO323314B1 (es)
PT (1) PT1282084E (es)
WO (1) WO2001066519A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
EP1477481B1 (en) * 2002-01-28 2009-07-22 Ube Industries, Ltd. Process for producing quinazolin-4-one derivative
JP5055263B2 (ja) 2005-03-30 2012-10-24 ダエウン ファーマシューティカル カンパニー リミテッド 抗真菌性トリアゾール誘導体
EP2009009A1 (en) * 2007-06-26 2008-12-31 Palau Pharma, S.A. Crystalline antifungal compounds
EP1887004A1 (en) * 2006-08-07 2008-02-13 Palau Pharma, S.A. Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
AU2007284851B2 (en) * 2006-08-07 2013-05-09 Palau Pharma, S.A. Crystalline antifungal compounds
TWI395728B (zh) 2006-12-06 2013-05-11 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
TWI415827B (zh) 2006-12-21 2013-11-21 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
EP2257555B1 (en) 2008-03-03 2012-07-04 National Chemical Laboratory Thieno[2,3-d]-pyrimidine-4(3h)-one compounds with antifungal properties and process thereof
SE532624C2 (sv) * 2008-06-19 2010-03-09 Andritz Technology And Asset Management Gmbh Kylning av en cellulosamassabana
WO2012123952A1 (en) * 2011-03-15 2012-09-20 Fdc Limited Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents
CN106588889B (zh) * 2016-11-25 2019-01-22 江苏恒盛药业有限公司 一种伏立康唑的制备方法
CN111018839B (zh) * 2019-12-02 2022-12-23 中国人民解放军第二军医大学 三氮唑醇类衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (es) 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
PT783501E (pt) * 1995-08-02 2001-04-30 Uriach & Cia Sa J Derivados de pirimidona com actividade antifungica

Also Published As

Publication number Publication date
CA2402390A1 (en) 2001-09-13
NO20024256D0 (no) 2002-09-06
DE60100810T2 (de) 2004-07-01
HK1052244B (zh) 2003-12-19
EP1282084B1 (en) 2003-09-17
EP1282084A2 (en) 2003-02-05
ES2159488A1 (es) 2001-10-01
BR0108990A (pt) 2003-12-30
MXPA02008556A (es) 2003-02-24
NO323314B1 (no) 2007-03-12
KR100735583B1 (ko) 2007-07-04
PT1282084E (pt) 2004-02-27
KR20020075809A (ko) 2002-10-05
BR0108990B1 (pt) 2014-03-25
CA2402390C (en) 2009-09-15
DK1282084T3 (da) 2004-02-02
ES2159488B1 (es) 2002-04-16
AU2001237447A1 (en) 2001-09-17
HK1052244A1 (en) 2003-09-05
WO2001066519A3 (es) 2002-01-31
JP2004500391A (ja) 2004-01-08
ES2207605T3 (es) 2004-06-01
DE60100810D1 (de) 2003-10-23
ATE250256T1 (de) 2003-10-15
NO20024256L (no) 2002-09-06
BRPI0108990B8 (pt) 2021-05-25
JP4772248B2 (ja) 2011-09-14
US20030064986A1 (en) 2003-04-03
US6653475B2 (en) 2003-11-25
WO2001066519A2 (es) 2001-09-13
EP1282084B9 (en) 2005-03-02

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