ES2084373T3 - Materiales y metodo para biosintesis de serina y productos afines a la serina. - Google Patents

Materiales y metodo para biosintesis de serina y productos afines a la serina.

Info

Publication number
ES2084373T3
ES2084373T3 ES92917826T ES92917826T ES2084373T3 ES 2084373 T3 ES2084373 T3 ES 2084373T3 ES 92917826 T ES92917826 T ES 92917826T ES 92917826 T ES92917826 T ES 92917826T ES 2084373 T3 ES2084373 T3 ES 2084373T3
Authority
ES
Spain
Prior art keywords
serine
dfg
dna
biosynthesis
manipulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917826T
Other languages
English (en)
Inventor
Richard P Burlingame
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wacker Chemie AG
Original Assignee
Wacker Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wacker Chemie AG filed Critical Wacker Chemie AG
Application granted granted Critical
Publication of ES2084373T3 publication Critical patent/ES2084373T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Tires In General (AREA)
  • Epoxy Resins (AREA)
  • Ceramic Products (AREA)

Abstract

SE PRESENTA ADN QUE CODIFICA LA DEHIDROGENASA 3-FOSFOGLICERADA (DFG) CON ESCASA SENSIBILIDAD A LA INHIBICION POR SERINA EN COMPARACION CON LA DFG NATURAL, ESTO ES, EL ADN CODIFICA DFG QUE TIENE ALGUN NIVEL DE ACTIVIDAD ENZIMATICA UTIL PARA LA BIOSINTESIS, Y DETIENE DICHA ACTIVIDAD EN NIVELES DE SERINA MAS ALTOS QUE LO HACE LA DFG NATURAL (NO MODIFICADA). TAMBIEN SE DESCUBREN: A) DFG CON LA SECUENCIA AMINOACIDA DEL ADN MANIPULADO ANTERIORMENTE DESCRITO; B) VECTORES DE EXPRESION QUE CONSTAN DEL ADN MANIPULADO Y ADN REGULADOR POSICIONADO Y ORIENTADO POR EXPRESION DEL ADN MANIPULADO EN UN SISTEMA DE EXPRESION ANFITRION; C) CELULAS QUE CONTIENEN TALES VECTORES DE EXPRESION; Y D) METODOS PARA PRODUCIR SERINA O PRODUCTOS DERIVADOS DE SERINA CULTIVANDO TALES CELULAS.
ES92917826T 1991-12-12 1992-08-17 Materiales y metodo para biosintesis de serina y productos afines a la serina. Expired - Lifetime ES2084373T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91121385 1991-12-12

Publications (1)

Publication Number Publication Date
ES2084373T3 true ES2084373T3 (es) 1996-05-01

Family

ID=8207424

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917826T Expired - Lifetime ES2084373T3 (es) 1991-12-12 1992-08-17 Materiales y metodo para biosintesis de serina y productos afines a la serina.

Country Status (19)

Country Link
US (1) US5618716A (es)
EP (1) EP0620853B1 (es)
JP (1) JP2584409B2 (es)
KR (1) KR0132258B1 (es)
CN (1) CN1065914C (es)
AU (1) AU668359B2 (es)
BR (1) BR9206902A (es)
CA (1) CA2124214C (es)
CZ (1) CZ285915B6 (es)
DE (1) DE69208894T2 (es)
ES (1) ES2084373T3 (es)
FI (1) FI113665B (es)
HU (1) HU217795B (es)
RU (1) RU2154671C1 (es)
SK (1) SK279805B6 (es)
TW (1) TW313589B (es)
UA (1) UA39861C2 (es)
WO (1) WO1993012235A1 (es)
ZA (1) ZA926405B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4232468A1 (de) * 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
JP4066543B2 (ja) * 1998-01-12 2008-03-26 味の素株式会社 発酵法によるｌ−セリンの製造法
JP3997631B2 (ja) 1998-01-12 2007-10-24 味の素株式会社 発酵法によるｌ−セリンの製造法
US6431870B1 (en) 1999-11-30 2002-08-13 Ora Metrix, Inc. Method and apparatus for generating a desired three-dimensional digital model of an orthodontic structure
US6350120B1 (en) 1999-11-30 2002-02-26 Orametrix, Inc. Method and apparatus for designing an orthodontic apparatus to provide tooth movement
US6250918B1 (en) 1999-11-30 2001-06-26 Orametrix, Inc. Method and apparatus for simulating tooth movement for an orthodontic patient
US6471512B1 (en) 1999-11-30 2002-10-29 Ora Metrix, Inc. Method and apparatus for determining and monitoring orthodontic treatment
US6540512B1 (en) 1999-11-30 2003-04-01 Orametrix, Inc. Method and apparatus for treating an orthodontic patient
AU2001259263A1 (en) * 2000-05-02 2001-11-12 Agrinomics, Llc Identification and characterization of a pagoda phenotype (pgd) in plants
DE10331291A1 (de) * 2003-07-10 2005-02-17 Consortium für elektrochemische Industrie GmbH Varianten der 3-Phosphoglyceratdehydrogenase mit reduzierter Hemmung durch L-Serin und dafür codierende Gene
AU2006220803A1 (en) 2005-03-07 2006-09-14 Align Technology, Inc. Variations of dental aligners
US20060275731A1 (en) 2005-04-29 2006-12-07 Orthoclear Holdings, Inc. Treatment of teeth by aligners
DE102005049527B4 (de) * 2005-10-17 2013-05-08 Forschungszentrum Jülich GmbH Verfahren zur Herstellung von L-Serin, Gensequenz, Vektoren sowie Mikroorganismus
RU2006129690A (ru) 2006-08-16 2008-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА ydiN, ГЕНА ydiB ИЛИ ИХ КОМБИНАЦИИ
JP2010017082A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010017081A (ja) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
BRPI0816429A2 (pt) 2007-09-04 2019-09-24 Ajinomoto Kk microorganismo, e, método para a produção de um l-aminoácido.
JP5332237B2 (ja) * 2008-03-06 2013-11-06 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
EP2138585B1 (en) * 2008-03-06 2011-02-09 Ajinomoto Co., Inc. An L-cysteine producing bacterium and a method for producing L-cysteine
ES2549003T3 (es) 2008-12-31 2015-10-22 Metabolic Explorer Método para la preparación de dioles
BR112012012915B1 (pt) * 2009-11-30 2020-12-01 Ajinomoto Co., Inc. método para produção de l-cisteína, l-cistina, um derivado das mesmas, ou uma mistura das mesmas
US8911978B2 (en) 2010-07-02 2014-12-16 Metabolic Explorer Method for the preparation of hydroxy acids
DE102011075656A1 (de) 2011-05-11 2012-03-29 Wacker Chemie Ag Verfahren zur fermentativen Produktion von L-Cystin
DE102011078481A1 (de) 2011-06-30 2013-01-03 Wacker Chemie Ag Verfahren zur fermentativen Produktion von natürlichem L-Cystein
DE102012208359A1 (de) 2012-05-18 2013-11-21 Wacker Chemie Ag Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure
DE102012216527A1 (de) 2012-09-17 2014-03-20 Wacker Chemie Ag Verfahren zur fermentativen Produktion von L-Cystein und Derivaten dieser Aminosäure
WO2014049382A2 (en) 2012-09-26 2014-04-03 Metabolic Explorer Ethylenediamine fermentative production by a recombinant microorganism
DE102013209274A1 (de) 2013-05-17 2014-11-20 Wacker Chemie Ag Mikroorganismus und Verfahren zur fermentativen Überproduktion von Gamma-Glutamylcystein und Derivaten dieses Dipeptids
CN113710807A (zh) 2019-02-20 2021-11-26 布拉斯科公司 用于由己糖生产含氧化合物的微生物和方法
EP3927816A1 (en) 2019-02-20 2021-12-29 Braskem S.A. Degradation pathway for pentose and hexose sugars
US20230265473A1 (en) 2020-06-26 2023-08-24 Wacker Chemie Ag Improved cysteine-producing strains
WO2023165684A1 (de) 2022-03-01 2023-09-07 Wacker Chemie Ag Verbesserte cystein produzierende stämme

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61247392A (ja) * 1985-02-04 1986-11-04 エンジニツクス　インコ−ポレ−テツド ２種またはより多くのアミノ酸を同時に産生できる組換え微生物
US4743546A (en) * 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
US4753883A (en) * 1986-05-07 1988-06-28 Biotechnica International, Inc. Enzyme deregulation
US4753833A (en) * 1986-09-26 1988-06-28 Fishgal Semyon I Hollow article with zigzag projections
GB8828806D0 (en) * 1988-12-09 1989-01-18 Beecham Group Plc Novel compounds
JP2967996B2 (ja) * 1989-06-06 1999-10-25 協和醗酵工業株式会社 Ｌ―トリプトファンの製造法
US5120837A (en) * 1989-09-20 1992-06-09 The Nutrasweet Company Dna encoding phe a feedback inhibition resistant enzyme analogues

Also Published As

Publication number Publication date
AU2426892A (en) 1993-07-19
CZ140694A3 (en) 1995-01-18
CN1073209A (zh) 1993-06-16
CA2124214C (en) 2002-04-02
CA2124214A1 (en) 1993-06-24
US5618716A (en) 1997-04-08
SK279805B6 (sk) 1999-04-13
AU668359B2 (en) 1996-05-02
RU2154671C1 (ru) 2000-08-20
UA39861C2 (uk) 2001-07-16
FI942711A0 (fi) 1994-06-09
HU217795B (hu) 2000-04-28
BR9206902A (pt) 1995-11-21
JP2584409B2 (ja) 1997-02-26
TW313589B (es) 1997-08-21
FI113665B (fi) 2004-05-31
WO1993012235A1 (en) 1993-06-24
CZ285915B6 (cs) 1999-11-17
HUT69802A (en) 1995-09-28
ZA926405B (en) 1993-04-28
EP0620853B1 (en) 1996-03-06
FI942711A (fi) 1994-06-09
CN1065914C (zh) 2001-05-16
DE69208894T2 (de) 1996-07-18
KR0132258B1 (ko) 1998-04-11
HU9400796D0 (en) 1994-06-28
SK70094A3 (en) 1995-03-08
DE69208894D1 (de) 1996-04-11
JPH06510911A (ja) 1994-12-08
EP0620853A1 (en) 1994-10-26

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