ES2075414T3 - Procedimiento enzimatico para la determinacion de antibioticos con nucleo de beta-lactama. - Google Patents

Procedimiento enzimatico para la determinacion de antibioticos con nucleo de beta-lactama.

Info

Publication number
ES2075414T3
ES2075414T3 ES91870070T ES91870070T ES2075414T3 ES 2075414 T3 ES2075414 T3 ES 2075414T3 ES 91870070 T ES91870070 T ES 91870070T ES 91870070 T ES91870070 T ES 91870070T ES 2075414 T3 ES2075414 T3 ES 2075414T3
Authority
ES
Spain
Prior art keywords
determination
lactama
antibiotics
beta
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91870070T
Other languages
English (en)
Inventor
Jacques Degelaen
Jean-Marie Frere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Bioproducts SA
Original Assignee
UCB Bioproducts SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Bioproducts SA filed Critical UCB Bioproducts SA
Application granted granted Critical
Publication of ES2075414T3 publication Critical patent/ES2075414T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/825—Actinomadura
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

COMPRENDE LAS SIGUIENTES ETAPAS: 1) INCUBACION DEL LIQUIDO BIOLOGICO CON LA D-ALANIL-D-ALANINACARBOXIPEPTIDOSA SOLUBLE PRODUCIDA POR LA CAPA ACTINOMADURA R39; 2) LA INCUBACION DE LA MEZCLA OBTENIDA CON UNA SOLUCION DE SUSTRATO QUE ES UN TIOESTER DE FORMULA EN PRESENCIA DE UN AMINOACIDO DE CONFIGURACION D O DE GLICINA; 3) LA DETERMINACION DE LA CANTIDAD DE ACIDO 2-MERCAPTOALCANOICO DE FORMULA FORMADO EN LA ETAPA 2); 4) LA COMPARACION DE LA DETERMINACION DE LA ETAPA 3) CON UN PATRON. EN ESTAS FORMULAS, R SUB 1 = BENZOILO, FENILACETILO O N ELEVADO ALPHA-ACETIL-L-LISILO, R SUB 2 = GLICILO O D-ALANILO Y R SUB 3 = H O CH SUB 3. LA INVENCION SE REFIERE TAMBIEN A UN ESTUCHE DE ENSAYO QUE COMPRENDE LOS REACTIVOS A APLICAR PARA LA EJECUCION DE ESTE PROCESO.
ES91870070T 1990-04-30 1991-04-26 Procedimiento enzimatico para la determinacion de antibioticos con nucleo de beta-lactama. Expired - Lifetime ES2075414T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909009692A GB9009692D0 (en) 1990-04-30 1990-04-30 An enzymatic method of determining beta-lactam ring antibiotics

Publications (1)

Publication Number Publication Date
ES2075414T3 true ES2075414T3 (es) 1995-10-01

Family

ID=10675235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91870070T Expired - Lifetime ES2075414T3 (es) 1990-04-30 1991-04-26 Procedimiento enzimatico para la determinacion de antibioticos con nucleo de beta-lactama.

Country Status (22)

Country Link
US (1) US5246830A (es)
EP (1) EP0468946B1 (es)
JP (1) JP2823382B2 (es)
AT (1) ATE124998T1 (es)
AU (1) AU636482B2 (es)
BG (1) BG61082B2 (es)
CA (1) CA2040180C (es)
CZ (1) CZ280282B6 (es)
DE (1) DE69111149T2 (es)
DK (1) DK0468946T3 (es)
ES (1) ES2075414T3 (es)
FI (1) FI97151C (es)
GB (1) GB9009692D0 (es)
GR (1) GR3017235T3 (es)
HU (1) HU214926B (es)
IE (1) IE69037B1 (es)
NO (1) NO302664B1 (es)
NZ (1) NZ237950A (es)
PL (1) PL169360B1 (es)
PT (1) PT97511B (es)
SK (1) SK279176B6 (es)
YU (1) YU48050B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519533A (ja) * 1997-10-07 2001-10-23 ユセベ バイオプロダクツ，ソシエテ アノニム 液状乳製品中の分析物を測定するためのアッセイ装置
US6143513A (en) * 1999-06-23 2000-11-07 Biacore Ab Method and kit for detecting betalactam-containing compounds
PL385415A1 (pl) * 2008-06-11 2009-12-21 Marek Ciesielski Sposób wykrywania bakteriooporności, zestaw diagnostyczny oraz zastosowanie oznaczania obecności leku i/lub produktów jego rozpadu
EP2766735B1 (en) * 2011-10-14 2017-02-01 Université de Liège Method for measuring beta-lactam antibiotics
CN111830015B (zh) * 2019-04-18 2022-12-09 中国农业科学院农产品加工研究所 一种定量检测抗生素的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2824863A (en) * 1952-11-14 1958-02-25 Ciba Pharm Prod Inc Acylmercapto compounds
US4166825A (en) * 1978-08-17 1979-09-04 Abbott Laboratories Chromogenic substrates
CA1185881A (en) * 1982-02-01 1985-04-23 Jacques Degelaen ENZYMATIC PROCESS FOR THE DETERMINATION OF .beta.-LACTAM ANTIBIOTICS
US4806478A (en) * 1984-10-17 1989-02-21 Minnesota Mining And Manufacturing Company Dry enzyme formulations containing D-amino acid oxidase
US4686182A (en) * 1984-10-17 1987-08-11 Minnesota Mining And Manufacturing Company Method and kit for detecting antibiotics in a liquid sample

Also Published As

Publication number Publication date
PT97511B (pt) 1998-08-31
ATE124998T1 (de) 1995-07-15
PL290061A1 (en) 1991-12-02
HU911441D0 (en) 1991-11-28
DK0468946T3 (da) 1995-10-09
IE911433A1 (en) 1991-11-06
EP0468946B1 (fr) 1995-07-12
CA2040180C (en) 2001-06-19
SK279176B6 (sk) 1998-07-08
NO911692D0 (no) 1991-04-29
JPH0686695A (ja) 1994-03-29
PL169360B1 (pl) 1996-07-31
CS9101246A2 (en) 1991-11-12
GB9009692D0 (en) 1990-06-20
CA2040180A1 (en) 1991-10-31
JP2823382B2 (ja) 1998-11-11
PT97511A (pt) 1992-01-31
FI97151C (fi) 1996-10-25
NO911692L (no) 1991-10-31
YU48050B (sh) 1996-10-18
CZ280282B6 (cs) 1995-12-13
AU636482B2 (en) 1993-04-29
YU78391A (sh) 1994-01-20
DE69111149T2 (de) 1995-12-07
HUT58825A (en) 1992-03-30
HU214926B (hu) 1998-07-28
AU7622691A (en) 1991-11-07
IE69037B1 (en) 1996-08-07
NZ237950A (en) 1992-02-25
DE69111149D1 (de) 1995-08-17
GR3017235T3 (en) 1995-11-30
FI97151B (fi) 1996-07-15
FI912054A (fi) 1991-10-31
NO302664B1 (no) 1998-04-06
BG61082B2 (bg) 1996-10-31
US5246830A (en) 1993-09-21
FI912054A0 (fi) 1991-04-29
EP0468946A1 (fr) 1992-01-29

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