ES2061745T3 - Aislamiento, purificacion, caracterizacion, clonacion y secuenciacion de n-alfa-acetiltransferasa. - Google Patents

Aislamiento, purificacion, caracterizacion, clonacion y secuenciacion de n-alfa-acetiltransferasa.

Info

Publication number
ES2061745T3
ES2061745T3 ES89102006T ES89102006T ES2061745T3 ES 2061745 T3 ES2061745 T3 ES 2061745T3 ES 89102006 T ES89102006 T ES 89102006T ES 89102006 T ES89102006 T ES 89102006T ES 2061745 T3 ES2061745 T3 ES 2061745T3
Authority
ES
Spain
Prior art keywords
alpha
cloning
sequencing
characterization
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89102006T
Other languages
English (en)
Inventor
John A Smith
Fang-Jen S Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of ES2061745T3 publication Critical patent/ES2061745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE AISLAN Y PURIFICAN UNAS N ALFA - ACETILTRANSFERENCIA CON UN PESO MOLECULAR DE ALREDEDOR DE 180000 UNIDADES DALTON COMPUESTAS DE DOS SUBUNIDADES DE GRUPOS PEPTONA TENIENDO PESOS MOLECULARES DE ALREDEDOR DE 95000 CADA UNO, TENIENDO ALTA ACTIVIDAD ENCIMATICA. LA CODIFICACION DE GENE PARA ESTE ENCIMA SE AISLA Y SECUENCIA. EL PUEDE SER INCORPORADO DENTRO DE MOLECULAS DE DNA RECOMBINANDO Y REPRESENTANDO UN VEHICULO PARA TRANSFORMACION DE CELULAS, ESPECIALMENTE CELULAS DE PLANTAS. ESTAS CELULAS PUEDEN CULTIVARSE PARA PLANTAS TENIENDO CAPACIDAD DE MEJORAR LA ACETILACCION.
ES89102006T 1988-02-08 1989-02-06 Aislamiento, purificacion, caracterizacion, clonacion y secuenciacion de n-alfa-acetiltransferasa. Expired - Lifetime ES2061745T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15336188A 1988-02-08 1988-02-08
US07/284,344 US4966848A (en) 1988-02-08 1988-12-14 Isolation, purification, characterization, cloning and sequencing of N α-acetyltransferase

Publications (1)

Publication Number Publication Date
ES2061745T3 true ES2061745T3 (es) 1994-12-16

Family

ID=26850470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89102006T Expired - Lifetime ES2061745T3 (es) 1988-02-08 1989-02-06 Aislamiento, purificacion, caracterizacion, clonacion y secuenciacion de n-alfa-acetiltransferasa.

Country Status (9)

Country Link
US (1) US4966848A (es)
EP (1) EP0334004B1 (es)
JP (1) JPH03502403A (es)
DE (1) DE68910713T2 (es)
DK (1) DK186390A (es)
ES (1) ES2061745T3 (es)
IE (1) IE890386L (es)
PT (1) PT89611B (es)
WO (1) WO1989007138A1 (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128459A (en) * 1988-02-08 1992-07-07 The General Hospital Corporation Isolation, purification, characterization, cloning and sequencing of N alpha-acetyltransferase
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
CA2071486A1 (en) * 1989-10-25 1991-04-26 John A. Smith Isolating of strains of saccharomyces cerevisiae having altered n.alpha.-acetyltransferase activity
US5223421A (en) * 1989-10-25 1993-06-29 The General Hospital Corporation Identification of methionine Nα-acetyltransferase
US8680059B2 (en) * 1998-05-20 2014-03-25 Biotempt B.V. Oligopeptide acetate and formulations thereof
US20030220258A1 (en) 2001-12-21 2003-11-27 Robbert Benner Treatment of ischemic events
NO986133D0 (no) * 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
EP1300418A1 (en) * 2001-10-04 2003-04-09 Erasmus Universiteit Rotterdam Gene regulation by oligopeptides
FR2807523B1 (fr) * 2000-04-07 2002-08-30 Inst Nat Sante Rech Med UTILISATION D'UN RESTE PyA-(Z)x-pNF A DES FINS DE DETECTION, IDENTIFICATION ET/OU DOSAGE PAR FLUORESCENCE
US20030109457A1 (en) * 2001-10-25 2003-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
DE10106852A1 (de) 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen
US7528227B2 (en) * 2004-03-23 2009-05-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Histone H2A peptide derivatives and uses thereof
JP2005525998A (ja) * 2001-08-30 2005-09-02 プラエシス ファーマシューティカルズ インコーポレーテッド 炎症性疾患の治療のための方法および組成物
US7238671B2 (en) * 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US20080318871A1 (en) * 2001-12-21 2008-12-25 Khan Nisar A Treatment of neurological disorders
US7786084B2 (en) * 2001-12-21 2010-08-31 Biotempt B.V. Treatment of burns
US20080242837A1 (en) * 2001-12-21 2008-10-02 Khan Nisar A Peptide compositions
WO2004079362A1 (en) * 2003-03-07 2004-09-16 University College Cork - National University Of Ireland, Cork A process for the synthesis of a chromatographic phase
WO2005051982A1 (ja) * 2003-11-28 2005-06-09 Toagosei Co,. Ltd. 糖ペプチド及び温度応答性ミセル
US20090227505A1 (en) * 2004-01-07 2009-09-10 Biotempt B.V. Methods and uses for protein breakdown products
JP4910700B2 (ja) * 2004-08-30 2012-04-04 東レ株式会社 分画装置
JP5159311B2 (ja) * 2004-10-18 2013-03-06 ビーエーエスエフ、ビューティー、ケア、ソルーションズ、フランス、エスエーエス オリゴペプチドおよびそれらの使用
US7563764B2 (en) * 2004-12-30 2009-07-21 E. I. Du Pont De Nemours And Company Antimicrobial peptides based on tripeptide repeats
MX2007008744A (es) 2005-01-20 2008-03-10 Biomarck Pharmaceuticals Ltd Inhibidores de hipersecrecion de mucina con base en la estructura de mans ymetodos de uso.
KR20080033331A (ko) * 2005-07-05 2008-04-16 바이오템프트, 비.브이. 종양 치료제
EP1782819A1 (en) * 2005-11-03 2007-05-09 Cognis IP Management GmbH Oligopeptides and their use
TWI303567B (en) * 2005-12-20 2008-12-01 Ind Tech Res Inst Oligopeptide, derivative thereof, and pharmaceutical composition comprising the same
WO2007098033A2 (en) * 2006-02-16 2007-08-30 University Of Georgia Research Foundation, Inc . Feedback prodrug
US7799758B2 (en) * 2006-02-23 2010-09-21 Ikaria Development Subsidiary Two, LLC Peptides and peptide derivatives as well as pharmaceutical compositions containing the same
EP1864692A1 (en) 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
FR2900826B1 (fr) * 2006-05-12 2008-08-15 Soc Extraction Principes Actif Utilisation de peptides en tant que principes actifs amincissants.
RU2423376C2 (ru) * 2006-07-26 2011-07-10 Байомарк Фармасьютикалз, Лтд. Способы ослабления высвобождения медиаторов воспаления и пептиды, применяемые для этой цели
US8507434B2 (en) * 2007-01-03 2013-08-13 The Johns Hopkins University Peptide modulators of angiogenesis and use thereof
CA2677948C (en) * 2007-02-12 2014-12-09 Biotempt B.V. Treatment of trauma-hemorrhage with short oligopeptides
CA2730132A1 (en) * 2008-07-21 2010-01-28 Compugen Ltd. Novel angiopoietin derived peptides
FR2940969B1 (fr) * 2009-01-09 2012-05-04 Isp Investments Inc Nouveaux peptides anti-age et composition cosmetique et/ou pharmaceutique les contenant
US8518957B2 (en) * 2009-12-02 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure
EP2382963A1 (en) * 2010-04-29 2011-11-02 Cognis IP Management GmbH Cosmetic composition containing oligopeptides
JP5943433B2 (ja) * 2011-01-20 2016-07-05 ワンデイ − バイオテク アンド ファーマ リミテッド 抗酸化、抗炎症、抗放射線、金属キレート化合物およびその使用
WO2012123018A1 (en) * 2011-03-15 2012-09-20 Nanomed3D S.R.L. Functionalized biomaterials for tissue regeneration
KR101285259B1 (ko) * 2011-08-04 2013-07-11 (주)케어젠 Ｗｎｔ 계열 유래 펩타이드 및 이의 용도
ES2810153T3 (es) * 2012-03-01 2021-03-08 Novo Nordisk As Profármacos de GLP-1
CA2879019A1 (en) 2012-07-23 2014-01-30 Oneday - Biotech And Pharma Ltd. Glutathione-elevating compositions and uses thereof
EP2877194A4 (en) 2012-07-25 2016-03-16 Oneday Biotech And Pharma Ltd Compositions and methods for increasing carnitine concentration in muscle tissue
EP2891663B8 (en) * 2012-08-31 2018-04-04 Vasculead Inc. Psf1-derived peptide
US20150265710A1 (en) * 2012-10-17 2015-09-24 Novo Nordisk A/S Fatty Acid Acylated D-Amino Acids for Oral Peptide Delivery
US10028999B2 (en) * 2014-05-11 2018-07-24 Tel Hashomer Medical Research Infrastructure And Services Ltd. PAR-1 based therapeutic conjugates and uses thereof
KR101470793B1 (ko) * 2014-06-30 2014-12-08 순천향대학교 산학협력단 흡수촉진제로서의 펩타이드와 이를 포함하는 조성물
JPWO2016129174A1 (ja) * 2015-02-09 2017-11-16 株式会社ファーマフーズ ヒアルロン酸産生促進剤
US9856302B2 (en) * 2015-07-23 2018-01-02 General Biologicals Corporation Anti-microbial peptide and method for treating microbial infection
US10829519B2 (en) * 2015-09-18 2020-11-10 Wake Forest University Health Sciences Angiotensin (1-7) analogs and methods relating thereto
TWI619503B (zh) * 2015-12-14 2018-04-01 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 短合成胜肽及其用途
US10286038B2 (en) * 2016-03-11 2019-05-14 Northwestern University Lysosome membrane protein 2 (LIMP-2) based peptides and related uses
WO2017194627A1 (en) * 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) New compounds and pharmaceutical use thereof in the treatment of cancer
US10981980B2 (en) * 2016-06-15 2021-04-20 Counterpoint Biomedica Llc Polypeptide targeting aptamers for characterization, capture, and clinical management of circulating tumor cells
CN109789180B (zh) * 2016-09-02 2023-09-08 伊利诺伊大学理事会 Kif13b衍生的肽和抑制血管生成的方法
JP2020513418A (ja) * 2016-12-13 2020-05-14 エモリー ユニバーシティ ウイルス感染を管理するためのポリペプチド
US11116817B2 (en) * 2017-02-17 2021-09-14 The Curators Of The University Of Missouri Antimicrobial agents and compositions comprising the same
US10570177B2 (en) * 2017-03-01 2020-02-25 The Chinese University Of Hong Kong P3 peptidylic inhibitors for treating CAG-repeat RNA toxicity in polyglutamine diseases
RU2678987C2 (ru) * 2017-04-28 2019-02-05 Общество с ограниченной ответственностью "Научно-производственная фирма ВЕРТА" Пептид для лечения болезни альцгеймера
ES2965807T3 (es) 2018-05-02 2024-04-16 Tel Hashomer Medical Res Infrastructure & Services Ltd Combinación de temozolomida y un conjugado de PAR-1 para tratar el glioblastoma
KR102234027B1 (ko) * 2018-05-09 2021-03-31 서울대학교산학협력단 B형 간염 바이러스 유래 폴리펩티드 및 이의 항바이러스 용도
US20220064214A1 (en) * 2019-01-07 2022-03-03 Cenna Biosciences Inc. Novel peptides and uses thereof
US11518784B2 (en) * 2019-05-08 2022-12-06 Creighton University 14-3-3 targeting peptides for cancer treatment
US11685766B2 (en) 2019-05-08 2023-06-27 Creighton University 14-3-3 targeting peptides for cancer treatment
WO2021011283A1 (en) 2019-07-12 2021-01-21 Northwestern University Insulin like growth factor binding protein bioactive peptide fragments

Also Published As

Publication number Publication date
AU3196989A (en) 1989-08-25
PT89611A (pt) 1989-10-04
AU616492B2 (en) 1991-10-31
DK186390D0 (da) 1990-08-03
DE68910713D1 (de) 1993-12-23
EP0334004B1 (en) 1993-11-18
DK186390A (da) 1990-08-03
DE68910713T2 (de) 1994-04-07
WO1989007138A1 (en) 1989-08-10
US4966848A (en) 1990-10-30
IE890386L (en) 1989-08-08
EP0334004A1 (en) 1989-09-27
PT89611B (pt) 1994-05-31
JPH03502403A (ja) 1991-06-06

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