ES2044957T3 - Metodo para obtener una preparacion para administracion intranasal. - Google Patents
Metodo para obtener una preparacion para administracion intranasal.Info
- Publication number
- ES2044957T3 ES2044957T3 ES87311054T ES87311054T ES2044957T3 ES 2044957 T3 ES2044957 T3 ES 2044957T3 ES 87311054 T ES87311054 T ES 87311054T ES 87311054 T ES87311054 T ES 87311054T ES 2044957 T3 ES2044957 T3 ES 2044957T3
- Authority
- ES
- Spain
- Prior art keywords
- intranasal administration
- obtain preparation
- phosphalidylcholine
- phospholipid
- lecithin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA ABSORCION SISTEMICA DESPUES DE LA ADMINISTRACION INTRANASAL DE CIERTOS MEDICAMENTOS, EN PARTICULAR POLIPEPTIDOS FARMACOLOGICAMENTE ACTIVOS, SE MEJORA EN PRESENCIA DE UN FOSFOLIPIDO, TAL COMO UNA FOSFALIDILCOLINA (UNA LECITINA), PREFERIBLEMENTE MEZCLADA CON UN ACEITE VEGETAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK604286A DK604286D0 (da) | 1986-12-16 | 1986-12-16 | Praeparat |
DK370087A DK370087D0 (da) | 1987-07-16 | 1987-07-16 | Produkt med forbedrede egenskaber |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2044957T3 true ES2044957T3 (es) | 1994-01-16 |
Family
ID=26067181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87311054T Expired - Lifetime ES2044957T3 (es) | 1986-12-16 | 1987-12-15 | Metodo para obtener una preparacion para administracion intranasal. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0272097B1 (es) |
JP (1) | JPH0768149B2 (es) |
KR (1) | KR890700036A (es) |
CN (1) | CN1034105C (es) |
AT (1) | ATE79039T1 (es) |
AU (1) | AU606121B2 (es) |
CA (1) | CA1326210C (es) |
CS (1) | CS273139B1 (es) |
DE (1) | DE3780925T2 (es) |
ES (1) | ES2044957T3 (es) |
FI (1) | FI94024C (es) |
GR (1) | GR3005381T3 (es) |
HU (1) | HU209247B (es) |
IE (1) | IE61110B1 (es) |
IL (1) | IL84835A (es) |
MX (1) | MX9203640A (es) |
NO (1) | NO175566C (es) |
NZ (1) | NZ222907A (es) |
PT (1) | PT86370B (es) |
RU (1) | RU1837869C (es) |
WO (1) | WO1988004556A1 (es) |
YU (1) | YU46978B (es) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5690954A (en) * | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
US5641474A (en) * | 1987-06-24 | 1997-06-24 | Autoimmune, Inc. | Prevention of autoimmune diseases by aerosol administration of autoantigens |
US5571500A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases through administration by inhalation of autoantigens |
US5571499A (en) * | 1987-06-24 | 1996-11-05 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
US5849298A (en) * | 1987-06-24 | 1998-12-15 | Autoimmune Inc. | Treatment of multiple sclerosis by oral administration of bovine myelin |
US5645820A (en) * | 1987-06-24 | 1997-07-08 | Autoimmune, Inc. | Treatment of autoimmune diseases by aerosol administration of autoantigens |
PT88490B (pt) * | 1987-09-14 | 1992-11-30 | Novo Nordisk As | Processo para a preparacao de composicoes farmaceuticas para libertacao nao-enterica trans-mucosa contendo monossacaridos ou oligossacaridos |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
ES2061688T3 (es) * | 1987-11-13 | 1994-12-16 | Smithkline Beecham Farma | Composiciones farmaceuticas que comprenden una calcitonina y un glicirricinato como mejorador de la absorcion. |
GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
ES2089011T3 (es) * | 1989-02-17 | 1996-10-01 | Liposome Co Inc | Excipiente lipidico de administracion nasal y aplicacion topica. |
IT8920486A0 (it) * | 1989-05-12 | 1989-05-12 | Isf Spa | Composizioni farmaceutiche. |
US5725871A (en) * | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
GB8918879D0 (en) * | 1989-08-18 | 1989-09-27 | Danbiosyst Uk | Pharmaceutical compositions |
GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
GB9012663D0 (en) * | 1990-06-07 | 1990-08-01 | Erba Carlo Spa | Galenic formulations containing cyclodextrins |
IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
DK36492D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Praeparat |
EP0566135A1 (en) * | 1992-04-17 | 1993-10-20 | Takeda Chemical Industries, Ltd. | Transmucosal composition comprising a peptide and a cytidine derivative |
DE4214953C2 (de) * | 1992-05-06 | 1995-05-18 | Arrowdean Ltd | Arzneimittel zur Erhöhung des Testosteronspiegels |
DE4218291A1 (de) * | 1992-06-03 | 1993-12-09 | Mattern Et Partner Pharmazeuti | Dosierspray für pernasale Applikation |
SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
US5830853A (en) * | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
US5747445A (en) * | 1993-06-24 | 1998-05-05 | Astra Aktiebolag | Therapeutic preparation for inhalation |
TW402506B (en) * | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
KR100419037B1 (ko) | 1994-03-07 | 2004-06-12 | 넥타르 테라퓨틱스 | 폐를통한인슐린의전달방법및그조성물 |
US6165976A (en) * | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
CA2201358C (en) * | 1994-09-30 | 2004-06-08 | Jurgen Regenold | Pharmaceutical composition |
SE9404468D0 (sv) * | 1994-12-22 | 1994-12-22 | Astra Ab | Powder formulations |
US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
US5856446A (en) * | 1995-07-07 | 1999-01-05 | Autoimmune Inc. | Method of treating rheumatoid arthritis with low dose type II collagen |
JPH11292787A (ja) * | 1995-08-15 | 1999-10-26 | Asahi Chem Ind Co Ltd | 生理活性ペプチドを含有する経粘膜投与製剤 |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
EP1826216A1 (en) | 1996-08-30 | 2007-08-29 | Novo Nordisk A/S | Glp-1 derivatives |
US6017545A (en) * | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
DE69942306D1 (de) | 1998-02-27 | 2010-06-10 | Novo Nordisk As | Abkömmlinge von glp-1 analogen |
JP2002506792A (ja) | 1998-02-27 | 2002-03-05 | ノボ ノルディスク アクティーゼルスカブ | N末端修飾glp−1誘導体 |
ATE466026T1 (de) | 1998-02-27 | 2010-05-15 | Novo Nordisk As | Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil |
TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
EP1306091A3 (en) | 1998-07-31 | 2003-05-21 | Novo Nordisk A/S | Stimulation of beta cell proliferation |
US6290987B1 (en) | 1998-09-27 | 2001-09-18 | Generex Pharmaceuticals, Inc. | Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids |
US6436367B1 (en) | 1998-12-21 | 2002-08-20 | Generex Pharmaceuticals Inc. | Aerosol formulations for buccal and pulmonary application |
US6849263B2 (en) | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
US6271200B1 (en) | 1998-12-21 | 2001-08-07 | Generex Pharmaceuticals Inc. | Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles |
US7087215B2 (en) | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
US6540982B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
AU2001237254A1 (en) | 2000-03-08 | 2001-09-17 | Novo-Nordisk A/S | Lowering serum lipids |
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
JP2004535432A (ja) * | 2001-06-22 | 2004-11-25 | ベントレー ファーマシューティカルズ インコーポレイテッド | 医薬組成物 |
US7244703B2 (en) | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
GB0205327D0 (en) * | 2002-03-06 | 2002-04-17 | Glaxo Group Ltd | compounds |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
DK2275439T3 (da) | 2003-08-05 | 2014-05-12 | Novo Nordisk As | Hidtil ukendte insulinderivater |
EP2264065B1 (en) | 2003-08-05 | 2017-03-08 | Novo Nordisk A/S | Novel insulin derivatives |
BR122019021416A2 (es) | 2003-09-19 | 2019-12-21 | ||
US7625865B2 (en) | 2004-03-26 | 2009-12-01 | Universita Degli Studi Di Parma | Insulin highly respirable microparticles |
CN1299770C (zh) * | 2004-05-31 | 2007-02-14 | 刘近周 | 多功能鼻腔和鼻窦洁疗液 |
BRPI0518761A2 (pt) | 2004-12-02 | 2008-12-09 | Domantis Ltd | fusço de droga, conjugado de droga, Ácido nucleico recombinante, construÇço de Ácido nucleico, cÉlula hospedeira, mÉtodo para produzir uma fusço de droga, composiÇço farmacÊutica, droga, mÉtodo de tratamento e/ou prevenÇço de uma condiÇço em um paciente, mÉtodo de retardo ou prevenÇço de progressço de doenÇa, e, mÉtodo para diminuir a absorÇço de alimentos por um paciente |
US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
EP2292653B1 (en) | 2005-02-02 | 2014-05-21 | Novo Nordisk A/S | Novel insulin derivatives |
DE602007009496D1 (de) | 2006-02-27 | 2010-11-11 | Novo Nordisk As | Insulinderivate |
JP5269767B2 (ja) | 2006-05-09 | 2013-08-21 | ノボ・ノルデイスク・エー/エス | インスリン誘導体 |
EP2024390B1 (en) | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Insulin derivative |
CN101743252A (zh) | 2007-07-16 | 2010-06-16 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、peg化的胰岛素类似物 |
JP5721432B2 (ja) | 2007-08-15 | 2015-05-20 | ノボ・ノルデイスク・エー/エス | アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン |
EP2178912B1 (en) | 2007-08-15 | 2015-07-08 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
JP5749155B2 (ja) | 2008-03-18 | 2015-07-15 | ノボ・ノルデイスク・エー/エス | プロテアーゼ安定化アシル化インスリンアナログ |
AU2009231439A1 (en) | 2008-03-31 | 2009-10-08 | Glaxo Group Limited | Drug fusions and conjugates |
EP2262539B1 (en) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin albumin conjugates |
US8277781B2 (en) | 2009-03-13 | 2012-10-02 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
US8551454B2 (en) | 2009-03-13 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Device for intranasal administration |
JP2012521971A (ja) | 2009-03-27 | 2012-09-20 | グラクソ グループ リミテッド | 薬物融合体および複合体 |
CN102666586A (zh) | 2009-09-30 | 2012-09-12 | 葛兰素集团有限公司 | 具有延长的半衰期的药物融合体和缀合物 |
EP2632478B1 (en) | 2010-10-27 | 2019-07-24 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections administered with varying injection intervals |
US9808030B2 (en) | 2011-02-11 | 2017-11-07 | Grain Processing Corporation | Salt composition |
WO2012136790A1 (en) | 2011-04-07 | 2012-10-11 | Glaxo Group Limited | Compositions comprising fusion proteins or conjugates with an improved half -life |
WO2012136792A2 (en) | 2011-04-07 | 2012-10-11 | Glaxo Group Limited | Cck compositions |
CN104244981A (zh) | 2011-12-09 | 2014-12-24 | 诺和诺德A/S | Glp-1激动剂 |
BR112014026442A8 (pt) | 2012-05-01 | 2018-01-16 | Novo Nordisk As | combinação para alcançar o controle glicêmico, seu uso, e composição farmacêutica. |
WO2014093688A1 (en) | 2012-12-12 | 2014-06-19 | 1Massachusetts Institute Of Technology | Compositions and methods for functional nucleic acid delivery |
US9867869B2 (en) | 2012-12-12 | 2018-01-16 | Massachusetts Institute Of Technology | Insulin derivatives for diabetes treatment |
WO2015081891A1 (en) | 2013-12-06 | 2015-06-11 | Baikang (Suzhou) Co., Ltd | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
CA2975562C (en) * | 2015-02-17 | 2020-04-28 | Eli Lilly And Company | Nasal powder formulation for treatment of hypoglycemia |
EP3873434A1 (en) | 2018-11-04 | 2021-09-08 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Nasal compositions and methods |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3594476A (en) * | 1969-05-12 | 1971-07-20 | Massachusetts Inst Technology | Submicron aqueous aerosols containing lecithin |
GB1527605A (en) * | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
NL193099C (nl) * | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
DE3228629A1 (de) * | 1982-07-31 | 1984-02-02 | Reifenrath, Rainer Richard Otto, Dr., 3104 Unterlüß | Pharmazeutisches erzeugnis zur behandlung der atemwege und verfahren zu seiner herstellung |
DE3323389A1 (de) * | 1983-06-29 | 1985-01-10 | B. Braun Melsungen Ag, 3508 Melsungen | Auf schleimhaeute des mundes, der nase und/oder des rachens wirkende arzneimittel auf der basis von heparin und tensiden |
GB8327330D0 (en) * | 1983-10-12 | 1983-11-16 | Parsons W J | Membrane analogue emulsions |
WO1985005029A1 (en) * | 1984-05-09 | 1985-11-21 | Medaphore Inc. | Oral insulin and a method of making the same |
GB8501015D0 (en) * | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
EP0200383A3 (en) * | 1985-04-15 | 1987-09-02 | Eli Lilly And Company | An improved method for administering insulin |
IT1187743B (it) * | 1985-09-26 | 1987-12-23 | Prodotti Formenti Srl | Composizioni farmaceutiche a base di destrorfano per applicazione instranasale |
-
1987
- 1987-12-14 NZ NZ222907A patent/NZ222907A/xx unknown
- 1987-12-15 IE IE340887A patent/IE61110B1/en not_active IP Right Cessation
- 1987-12-15 KR KR1019880700999A patent/KR890700036A/ko not_active Application Discontinuation
- 1987-12-15 DE DE8787311054T patent/DE3780925T2/de not_active Expired - Lifetime
- 1987-12-15 JP JP63501126A patent/JPH0768149B2/ja not_active Expired - Fee Related
- 1987-12-15 HU HU88642A patent/HU209247B/hu not_active IP Right Cessation
- 1987-12-15 AT AT87311054T patent/ATE79039T1/de not_active IP Right Cessation
- 1987-12-15 EP EP87311054A patent/EP0272097B1/en not_active Expired - Lifetime
- 1987-12-15 AU AU10858/88A patent/AU606121B2/en not_active Ceased
- 1987-12-15 PT PT86370A patent/PT86370B/pt not_active IP Right Cessation
- 1987-12-15 IL IL8483587A patent/IL84835A/en not_active IP Right Cessation
- 1987-12-15 ES ES87311054T patent/ES2044957T3/es not_active Expired - Lifetime
- 1987-12-15 MX MX9203640A patent/MX9203640A/es unknown
- 1987-12-15 WO PCT/DK1987/000158 patent/WO1988004556A1/en active IP Right Grant
- 1987-12-16 YU YU228487A patent/YU46978B/sh unknown
- 1987-12-16 CN CN87108340A patent/CN1034105C/zh not_active Expired - Fee Related
- 1987-12-16 CS CS930487A patent/CS273139B1/cs unknown
- 1987-12-16 CA CA000554555A patent/CA1326210C/en not_active Expired - Fee Related
-
1988
- 1988-08-15 FI FI883783A patent/FI94024C/fi not_active IP Right Cessation
- 1988-08-15 NO NO883627A patent/NO175566C/no not_active IP Right Cessation
- 1988-08-15 RU SU884356382A patent/RU1837869C/ru active
-
1992
- 1992-08-06 GR GR920401718T patent/GR3005381T3/el unknown
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