ES2033703T3 - Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. - Google Patents
Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza.Info
- Publication number
- ES2033703T3 ES2033703T3 ES198787102566T ES87102566T ES2033703T3 ES 2033703 T3 ES2033703 T3 ES 2033703T3 ES 198787102566 T ES198787102566 T ES 198787102566T ES 87102566 T ES87102566 T ES 87102566T ES 2033703 T3 ES2033703 T3 ES 2033703T3
- Authority
- ES
- Spain
- Prior art keywords
- nicotinic acid
- high purity
- procedure
- thick crystals
- preparing nicotinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 6
- 235000001968 nicotinic acid Nutrition 0.000 title abstract 4
- 239000011664 nicotinic acid Substances 0.000 title abstract 4
- 229960003512 nicotinic acid Drugs 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title 1
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- -1 alkali metal nicotinate Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863614019 DE3614019A1 (de) | 1986-04-25 | 1986-04-25 | Verfahren zur herstellung grobkristalliner nicotinsaeure hoher reinheit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2033703T3 true ES2033703T3 (es) | 1993-04-01 |
Family
ID=6299517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787102566T Expired - Lifetime ES2033703T3 (es) | 1986-04-25 | 1987-02-24 | Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. |
Country Status (8)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| BR9707375A (pt) * | 1996-02-09 | 1999-07-20 | Reilly Ind Inc | Processos contínuos para a hidrólise de cianopiridinas sob condições substancialmente adiabáticas |
| KR20160036559A (ko) * | 2013-07-26 | 2016-04-04 | 디에스엠 아이피 어셋츠 비.브이. | 방향족 고리계를 갖는 유기 산 또는 에스터의 개선된 분말형 제형 |
| CN116462629A (zh) * | 2023-04-27 | 2023-07-21 | 安徽瑞邦生物科技有限公司 | 一种烟酸分离提纯的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE6129C (de) * | GUTEHOFFNUNGSHÜTTE, AKTIENVEREIN FÜR BERGBAU UND HÜTTENBETRIEB in Oberhausen II. a. d. Ruhr | Selbstthätige Kippvorrichtung für Eisenbahnwagen | ||
| DE828246C (de) | 1948-10-02 | 1953-07-02 | Degussa | Verfahren zur Herstellung von Nicotinsaeure |
| BE756534A (fr) | 1969-09-24 | 1971-03-01 | Lonza Ag | Procede de fabrication d'acides pyridine-carboxyliques |
| US4001257A (en) | 1972-12-02 | 1977-01-04 | Nippon Soda Company Limited | Process for producing nicotinic acid |
| US3920670A (en) | 1973-10-10 | 1975-11-18 | Sun Ventures Inc | Process for hydrolysis of nitriles |
| GB1474461A (en) * | 1973-11-15 | 1977-05-25 | Lummus Co | Production of nicotinic acid |
| US3929811A (en) * | 1973-11-15 | 1975-12-30 | Lummus Co | Production of pyridine nitriles and carboxylic acids |
| US3922147A (en) | 1974-04-05 | 1975-11-25 | Lummus Co | Hydrolysis reactor |
-
1986
- 1986-04-25 DE DE19863614019 patent/DE3614019A1/de not_active Withdrawn
-
1987
- 1987-02-24 EP EP87102566A patent/EP0242535B1/de not_active Expired - Lifetime
- 1987-02-24 ES ES198787102566T patent/ES2033703T3/es not_active Expired - Lifetime
- 1987-02-24 AT AT87102566T patent/ATE80875T1/de active
- 1987-02-24 DE DE8787102566T patent/DE3781824D1/de not_active Expired - Lifetime
- 1987-04-13 BR BR8701742A patent/BR8701742A/pt unknown
- 1987-04-23 JP JP62098791A patent/JPS62255481A/ja active Granted
- 1987-04-24 CA CA000535511A patent/CA1294625C/en not_active Expired - Lifetime
-
1989
- 1989-02-28 US US07/318,414 patent/US4959478A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR8701742A (pt) | 1988-01-12 |
| US4959478A (en) | 1990-09-25 |
| ATE80875T1 (de) | 1992-10-15 |
| EP0242535B1 (de) | 1992-09-23 |
| CA1294625C (en) | 1992-01-21 |
| JPH0588708B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-12-24 |
| DE3614019A1 (de) | 1987-11-05 |
| JPS62255481A (ja) | 1987-11-07 |
| EP0242535A3 (en) | 1988-02-03 |
| DE3781824D1 (de) | 1992-10-29 |
| EP0242535A2 (de) | 1987-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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