ES2033703T3 - Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. - Google Patents

Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza.

Info

Publication number
ES2033703T3
ES2033703T3 ES198787102566T ES87102566T ES2033703T3 ES 2033703 T3 ES2033703 T3 ES 2033703T3 ES 198787102566 T ES198787102566 T ES 198787102566T ES 87102566 T ES87102566 T ES 87102566T ES 2033703 T3 ES2033703 T3 ES 2033703T3
Authority
ES
Spain
Prior art keywords
nicotinic acid
high purity
procedure
thick crystals
preparing nicotinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787102566T
Other languages
English (en)
Inventor
Alexander Dr. Moller
Heinz Dr. Friedrich
Herbert Dr. Kuhn
Kurt Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Application granted granted Critical
Publication of ES2033703T3 publication Critical patent/ES2033703T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENCION DE ACIDO NICOTINICO DE CRISTAL GRUESO DE ELEVADA PUREZA, EN EL CUAL SE SAPONIFICA LA 3-CIANOPIRIDINA CON HIDROXIDO ALCALINO ACUOSO Y DE LA SOLUCION DE NICOTINATO ALCALINO ASI OBTENIDA, POR ADICION DE ACIDO MINERAL A TEMPERATURA ENTRE 99 Y 135 GRADOS CENTIGRADOS CRISTALIZA EL ACIDO NICOTINICO. EL VALOR DE PH EN NINGUN CASO ALCANZA 3,7.
ES198787102566T 1986-04-25 1987-02-24 Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. Expired - Lifetime ES2033703T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863614019 DE3614019A1 (de) 1986-04-25 1986-04-25 Verfahren zur herstellung grobkristalliner nicotinsaeure hoher reinheit

Publications (1)

Publication Number Publication Date
ES2033703T3 true ES2033703T3 (es) 1993-04-01

Family

ID=6299517

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787102566T Expired - Lifetime ES2033703T3 (es) 1986-04-25 1987-02-24 Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza.

Country Status (8)

Country Link
US (1) US4959478A (es)
EP (1) EP0242535B1 (es)
JP (1) JPS62255481A (es)
AT (1) ATE80875T1 (es)
BR (1) BR8701742A (es)
CA (1) CA1294625C (es)
DE (2) DE3614019A1 (es)
ES (1) ES2033703T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
JP2000504686A (ja) * 1996-02-09 2000-04-18 レイリー・インダストリーズ・インコーポレーテッド 実質的に断熱条件下でのシアノピリジンの連続加水分解方法
CN105407742A (zh) * 2013-07-26 2016-03-16 帝斯曼知识产权资产管理有限公司 具有芳环体系的有机酸或酯的改进粉末制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE6129C (de) * GUTEHOFFNUNGSHÜTTE, AKTIENVEREIN FÜR BERGBAU UND HÜTTENBETRIEB in Oberhausen II. a. d. Ruhr Selbstthätige Kippvorrichtung für Eisenbahnwagen
DE828246C (de) 1948-10-02 1953-07-02 Degussa Verfahren zur Herstellung von Nicotinsaeure
BE756534A (fr) 1969-09-24 1971-03-01 Lonza Ag Procede de fabrication d'acides pyridine-carboxyliques
US4001257A (en) 1972-12-02 1977-01-04 Nippon Soda Company Limited Process for producing nicotinic acid
US3920670A (en) 1973-10-10 1975-11-18 Sun Ventures Inc Process for hydrolysis of nitriles
GB1474461A (en) * 1973-11-15 1977-05-25 Lummus Co Production of nicotinic acid
US3929811A (en) * 1973-11-15 1975-12-30 Lummus Co Production of pyridine nitriles and carboxylic acids
US3922147A (en) 1974-04-05 1975-11-25 Lummus Co Hydrolysis reactor

Also Published As

Publication number Publication date
EP0242535A3 (en) 1988-02-03
BR8701742A (pt) 1988-01-12
ATE80875T1 (de) 1992-10-15
JPS62255481A (ja) 1987-11-07
DE3614019A1 (de) 1987-11-05
EP0242535A2 (de) 1987-10-28
DE3781824D1 (de) 1992-10-29
US4959478A (en) 1990-09-25
EP0242535B1 (de) 1992-09-23
JPH0588708B2 (es) 1993-12-24
CA1294625C (en) 1992-01-21

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