ES2033703T3 - Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. - Google Patents
Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza.Info
- Publication number
- ES2033703T3 ES2033703T3 ES198787102566T ES87102566T ES2033703T3 ES 2033703 T3 ES2033703 T3 ES 2033703T3 ES 198787102566 T ES198787102566 T ES 198787102566T ES 87102566 T ES87102566 T ES 87102566T ES 2033703 T3 ES2033703 T3 ES 2033703T3
- Authority
- ES
- Spain
- Prior art keywords
- nicotinic acid
- high purity
- procedure
- thick crystals
- preparing nicotinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENCION DE ACIDO NICOTINICO DE CRISTAL GRUESO DE ELEVADA PUREZA, EN EL CUAL SE SAPONIFICA LA 3-CIANOPIRIDINA CON HIDROXIDO ALCALINO ACUOSO Y DE LA SOLUCION DE NICOTINATO ALCALINO ASI OBTENIDA, POR ADICION DE ACIDO MINERAL A TEMPERATURA ENTRE 99 Y 135 GRADOS CENTIGRADOS CRISTALIZA EL ACIDO NICOTINICO. EL VALOR DE PH EN NINGUN CASO ALCANZA 3,7.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863614019 DE3614019A1 (de) | 1986-04-25 | 1986-04-25 | Verfahren zur herstellung grobkristalliner nicotinsaeure hoher reinheit |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2033703T3 true ES2033703T3 (es) | 1993-04-01 |
Family
ID=6299517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787102566T Expired - Lifetime ES2033703T3 (es) | 1986-04-25 | 1987-02-24 | Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4959478A (es) |
EP (1) | EP0242535B1 (es) |
JP (1) | JPS62255481A (es) |
AT (1) | ATE80875T1 (es) |
BR (1) | BR8701742A (es) |
CA (1) | CA1294625C (es) |
DE (2) | DE3614019A1 (es) |
ES (1) | ES2033703T3 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
CN1173949C (zh) * | 1996-02-09 | 2004-11-03 | 莱利工业公司 | 在基本上绝热的条件下氰基吡啶类水解的连续式方式 |
US9693938B2 (en) * | 2013-07-26 | 2017-07-04 | Dsm Ip Assets B.V. | Powderous formulations of organic acids or esters having an aromatic ring system |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE6129C (de) * | GUTEHOFFNUNGSHÜTTE, AKTIENVEREIN FÜR BERGBAU UND HÜTTENBETRIEB in Oberhausen II. a. d. Ruhr | Selbstthätige Kippvorrichtung für Eisenbahnwagen | ||
DE828246C (de) * | 1948-10-02 | 1953-07-02 | Degussa | Verfahren zur Herstellung von Nicotinsaeure |
BE756534A (fr) | 1969-09-24 | 1971-03-01 | Lonza Ag | Procede de fabrication d'acides pyridine-carboxyliques |
US4001257A (en) | 1972-12-02 | 1977-01-04 | Nippon Soda Company Limited | Process for producing nicotinic acid |
US3920670A (en) | 1973-10-10 | 1975-11-18 | Sun Ventures Inc | Process for hydrolysis of nitriles |
US3929811A (en) * | 1973-11-15 | 1975-12-30 | Lummus Co | Production of pyridine nitriles and carboxylic acids |
GB1474461A (en) * | 1973-11-15 | 1977-05-25 | Lummus Co | Production of nicotinic acid |
US3922147A (en) | 1974-04-05 | 1975-11-25 | Lummus Co | Hydrolysis reactor |
-
1986
- 1986-04-25 DE DE19863614019 patent/DE3614019A1/de not_active Withdrawn
-
1987
- 1987-02-24 DE DE8787102566T patent/DE3781824D1/de not_active Expired - Lifetime
- 1987-02-24 AT AT87102566T patent/ATE80875T1/de active
- 1987-02-24 ES ES198787102566T patent/ES2033703T3/es not_active Expired - Lifetime
- 1987-02-24 EP EP87102566A patent/EP0242535B1/de not_active Expired - Lifetime
- 1987-04-13 BR BR8701742A patent/BR8701742A/pt unknown
- 1987-04-23 JP JP62098791A patent/JPS62255481A/ja active Granted
- 1987-04-24 CA CA000535511A patent/CA1294625C/en not_active Expired - Lifetime
-
1989
- 1989-02-28 US US07/318,414 patent/US4959478A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3614019A1 (de) | 1987-11-05 |
DE3781824D1 (de) | 1992-10-29 |
EP0242535A2 (de) | 1987-10-28 |
CA1294625C (en) | 1992-01-21 |
ATE80875T1 (de) | 1992-10-15 |
US4959478A (en) | 1990-09-25 |
JPS62255481A (ja) | 1987-11-07 |
BR8701742A (pt) | 1988-01-12 |
EP0242535A3 (en) | 1988-02-03 |
EP0242535B1 (de) | 1992-09-23 |
JPH0588708B2 (es) | 1993-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2033703T3 (es) | Procedimiento para preparar acido nicotinico en cristales gruesos de alta pureza. | |
DK122187A (da) | Fremgangsmaade til fremstilling af dermatansulfat og farmaceutisk praeparat indeholdende dermantansulfat | |
ES2033388T3 (es) | Procedimiento para preparar sales de metales alcalinos del acido 2-pirrolidon-5-carboxilico. | |
YU249182A (en) | Process for the manufacture of cupric hydroxide | |
ES8304084A1 (es) | "procedimiento para la preparacion de la sal de zinc de 2-mercaptopiridin-n-oxido en una forma facilmente filtrable pero bien suspendible". | |
DE3272660D1 (en) | New beta-lactam acetic acid derivatives, the process for preparing them, and their use as intermediates for 1-azabicyclo(3.2.0.)hept-2-ene antibiotics | |
PT84819B (pt) | Processo para a preparacao de compostos 2-piridil-penem | |
EP0312783A3 (en) | Process for the preparation of alkali earth metal salts of 2-pyrrolidinone-5-carboxylic acid | |
DE3569236D1 (en) | Process for the preparation of 6-(low)alkoxy-1-naphthoic acids, possibly halogenated at position 5, and the corresponding esters | |
GB934292A (en) | Process for the preparation of heterocyclic compounds | |
ES2059455T3 (es) | Procedimiento para la preparacion de purinas sodicas. | |
ES494260A0 (es) | Procedimiento para transformar la estructura de insulina quecristaliza de forma romboedrica | |
JPS6483519A (en) | Production of basic crystallized zirconia-based sol | |
SE7907815L (sv) | Cefalosporinforeningar | |
KR900017999A (ko) | 트리스(2-시아노에틸) 아민의 제조 방법 | |
DE3068259D1 (en) | Directly injectable aqueous solutions of the alkali salts of canrenoic acid and of furosemide, and process for their production | |
ES459223A1 (es) | Procedimiento para la preparacion de sales alcalinos de am- picilina, especialmente de ampicilina sodica. | |
JPS6442489A (en) | Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid | |
ES2021290B3 (es) | Procedimiento para la obtencion de fosfoformiatos alcalinos. | |
GB873995A (en) | Sulfuric acid esters of dextranic acid | |
ES2007387A6 (es) | Procedimiento para la obtencion de un derivado del acido cromoglicico | |
JPS6483518A (en) | Basic crystallized zirconia-based sol | |
KR910018343A (ko) | N-(4-니트로페닐카바모일)-l-아스파트산의 제조방법 | |
KR860001800A (ko) | 6-플루오로-1,8-나프티리딘 유도체, 그의 3/2수화물 및 그 염의 제조방법 | |
JPS54144376A (en) | Preparation of fusaric acid and its calcium salt |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 242535 Country of ref document: ES |